529 research outputs found
Borel summability and Lindstedt series
Resonant motions of integrable systems subject to perturbations may continue
to exist and to cover surfaces with parametric equations admitting a formal
power expansion in the strength of the perturbation. Such series may be,
sometimes, summed via suitable sum rules defining functions of the
perturbation strength: here we find sufficient conditions for the Borel
summability of their sums in the case of two-dimensional rotation vectors with
Diophantine exponent (e. g. with ratio of the two independent
frequencies equal to the golden mean).Comment: 17 pages, 1 figur
Germline TP53 alterations in Finnish breast cancer families are rare and occur at conserved mutation-prone sites
We have screened for germline TP53 mutations in Finnish BRCA1 and BRCA2 mutation-negative families. This study represents the largest survey of the entire protein-encoding portion of TP53, and indicates that mutations are only found at conserved domains in breast cancer families also meeting the criteria for Li-Fraumeni/Li-Fraumeni-like syndrome, explaining only a very small additional fraction of the hereditary breast cancer cases. © 2001 Cancer Research Campaign http://www.bjcancer.co
Polygenic risk modeling for prediction of epithelial ovarian cancer risk
Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individual level genotype data and a Bayesian framework with continuous shrinkage, "select and shrink for summary statistics" (S4), to summary level data for epithelial non-mucinous ovarian cancer risk prediction. We developed the models in a dataset consisting of 23,564 non-mucinous EOC cases and 40,138 controls participating in the Ovarian Cancer Association Consortium (OCAC) and validated the best models in three populations of different ancestries: prospective data from 198,101 women of European ancestries; 7,669 women of East Asian ancestries; 1,072 women of African ancestries, and in 18,915 BRCA1 and 12,337 BRCA2 pathogenic variant carriers of European ancestries. In the external validation data, the model with the strongest association for non-mucinous EOC risk derived from the OCAC model development data was the S4 model (27,240 SNPs) with odds ratios (OR) of 1.38 (95% CI: 1.28-1.48, AUC: 0.588) per unit standard deviation, in women of European ancestries; 1.14 (95% CI: 1.08-1.19, AUC: 0.538) in women of East Asian ancestries; 1.38 (95% CI: 1.21-1.58, AUC: 0.593) in women of African ancestries; hazard ratios of 1.36 (95% CI: 1.29-1.43, AUC: 0.592) in BRCA1 pathogenic variant carriers and 1.49 (95% CI: 1.35-1.64, AUC: 0.624) in BRCA2 pathogenic variant carriers. Incorporation of the S4 PRS in risk prediction models for ovarian cancer may have clinical utility in ovarian cancer prevention programs.Peer reviewe
Section Extension from Hyperbolic Geometry of Punctured Disk and Holomorphic Family of Flat Bundles
The construction of sections of bundles with prescribed jet values plays a
fundamental role in problems of algebraic and complex geometry. When the jet
values are prescribed on a positive dimensional subvariety, it is handled by
theorems of Ohsawa-Takegoshi type which give extension of line bundle valued
square-integrable top-degree holomorphic forms from the fiber at the origin of
a family of complex manifolds over the open unit 1-disk when the curvature of
the metric of line bundle is semipositive. We prove here an extension result
when the curvature of the line bundle is only semipositive on each fiber with
negativity on the total space assumed bounded from below and the connection of
the metric locally bounded, if a square-integrable extension is known to be
possible over a double point at the origin. It is a Hensel-lemma-type result
analogous to Artin's application of the generalized implicit function theorem
to the theory of obstruction in deformation theory. The motivation is the need
in the abundance conjecture to construct pluricanonical sections from flatly
twisted pluricanonical sections. We also give here a new approach to the
original theorem of Ohsawa-Takegoshi by using the hyperbolic geometry of the
punctured open unit 1-disk to reduce the original theorem of Ohsawa-Takegoshi
to a simple application of the standard method of constructing holomorphic
functions by solving the d-bar equation with cut-off functions and additional
blowup weight functions
Multipoint Schur algorithm and orthogonal rational functions: convergence properties, I
Classical Schur analysis is intimately connected to the theory of orthogonal
polynomials on the circle [Simon, 2005]. We investigate here the connection
between multipoint Schur analysis and orthogonal rational functions.
Specifically, we study the convergence of the Wall rational functions via the
development of a rational analogue to the Szeg\H o theory, in the case where
the interpolation points may accumulate on the unit circle. This leads us to
generalize results from [Khrushchev,2001], [Bultheel et al., 1999], and yields
asymptotics of a novel type.Comment: a preliminary version, 39 pages; some changes in the Introduction,
Section 5 (Szeg\H o type asymptotics) is extende
High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer
Peer reviewe
Pseudo-Hermitian Representation of Quantum Mechanics
A diagonalizable non-Hermitian Hamiltonian having a real spectrum may be used
to define a unitary quantum system, if one modifies the inner product of the
Hilbert space properly. We give a comprehensive and essentially self-contained
review of the basic ideas and techniques responsible for the recent
developments in this subject. We provide a critical assessment of the role of
the geometry of the Hilbert space in conventional quantum mechanics to reveal
the basic physical principle motivating our study. We then offer a survey of
the necessary mathematical tools and elaborate on a number of relevant issues
of fundamental importance. In particular, we discuss the role of the antilinear
symmetries such as PT, the true meaning and significance of the charge
operators C and the CPT-inner products, the nature of the physical observables,
the equivalent description of such models using ordinary Hermitian quantum
mechanics, the pertaining duality between local-non-Hermitian versus
nonlocal-Hermitian descriptions of their dynamics, the corresponding classical
systems, the pseudo-Hermitian canonical quantization scheme, various methods of
calculating the (pseudo-) metric operators, subtleties of dealing with
time-dependent quasi-Hermitian Hamiltonians and the path-integral formulation
of the theory, and the structure of the state space and its ramifications for
the quantum Brachistochrone problem. We also explore some concrete physical
applications of the abstract concepts and tools that have been developed in the
course of this investigation. These include applications in nuclear physics,
condensed matter physics, relativistic quantum mechanics and quantum field
theory, quantum cosmology, electromagnetic wave propagation, open quantum
systems, magnetohydrodynamics, quantum chaos, and biophysics.Comment: 76 pages, 2 figures, 243 references, published as Int. J. Geom. Meth.
Mod. Phys. 7, 1191-1306 (2010
Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers
Peer reviewedPublisher PD
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