2 research outputs found
ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ² Π² ΠΊΡΠΎΠ²ΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ ΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π·ΠΎΠΌ, Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ Ρ Π²ΠΈΡ-ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ
In the present work the data of comparative studying the cytokine status (serum concentration and spontaneous production IL-4, IFN-g, TNF-a) at HIV-infected and HIV-non infected persons with the active for the first time revealed tuberculosis, and also an establishment of possible interrelation between these parameters and amount of virus loading, level CD4+T-cell in blood of HIV- infecte patients from TB (group HIV/TB). In process of progressing associated HIV/Π’Π infections and development of heavier forms of TB the increase serum content IFN-g and TNF-a testifying about displacement of balance aside increases proinflammatory cytokines on a background of decrease in number CD4+T-cell, increase of virus loading of a HIV is marked. The received results testify about immunosupreses with an exhaustion of functional reserves mononuclear cells of the peripheral blood aggravated in process of progressing of disease, being one of pathogenetic mechanisms of formation of secondary diseases, both virus, and the bacterial nature.Π Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΠ° (ΡΡΠ²ΠΎΡΠΎΡΠΎΡΠ½ΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΠΈ ΡΠΏΠΎΠ½ΡΠ°Π½Π½ΠΎΠΉ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ IL-4, IFN-g, TNF-a) Ρ ΠΠΠ§-ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΈ ΠΠΠ§-Π΅ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π»ΠΈΡ Ρ Π°ΠΊΡΠΈΠ²Π½ΡΠΌ Π²ΠΏΠ΅ΡΠ²ΡΠ΅ Π²ΡΡΠ²Π»Π΅Π½Π½ΡΠΌ ΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π·ΠΎΠΌ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠΉ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΠΈΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΠΈ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎΠΌ Π²ΠΈΡΡΡΠ½ΠΎΠΉ Π½Π°Π³ΡΡΠ·ΠΊΠΈ, ΡΡΠΎΠ²Π½Π΅ΠΌ CD4+T-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² Π² ΠΊΡΠΎΠ²ΠΈ ΠΠΠ§-ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π°ΠΊΡΠΈΠ²Π½ΡΠΌ Π²ΠΏΠ΅ΡΠ²ΡΠ΅ Π²ΡΡΠ²Π»Π΅Π½Π½ΡΠΌ ΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π·ΠΎΠΌ (Π³ΡΡΠΏΠΏΠ° ΠΠΠ§/Π’Π). ΠΠΎ ΠΌΠ΅ΡΠ΅ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΠΠ§/Π’Π ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π±ΠΎΠ»Π΅Π΅ ΡΡΠΆΠ΅Π»ΡΡ
ΡΠΎΡΠΌ ΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π·Π° ΠΎΡΠΌΠ΅ΡΠ°Π΅ΡΡΡ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΡΠ²ΠΎΡΠΎΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ IFN-g ΠΈ TNF-a, ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡΠ΅Π΅ ΠΎ ΡΠΌΠ΅ΡΠ΅Π½ΠΈΠΈ Π±Π°Π»Π°Π½ΡΠ° Π² ΡΡΠΎΡΠΎΠ½Ρ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ² Π½Π° ΡΠΎΠ½Π΅ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΠΈΡΠ»Π° CD4+T-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ², Π½Π°ΡΠ°ΡΡΠ°Π½ΠΈΡ Π²ΠΈΡΡΡΠ½ΠΎΠΉ Π½Π°Π³ΡΡΠ·ΠΊΠΈ ΠΠΠ§. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡ ΠΎΠ± ΠΈΠΌΠΌΡΠ½ΠΎΡΡΠΏΡΠ΅ΡΡΠΈΠΈ Ρ ΠΈΡΡΠΎΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΡΠ΅Π·Π΅ΡΠ²ΠΎΠ² ΠΌΠΎΠ½ΠΎΠ½ΡΠΊΠ»Π΅ΠΎΠ½Π°ΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ, ΡΡΡΠ³ΡΠ±Π»ΡΡΡΠ΅ΠΉΡΡ ΠΏΠΎ ΠΌΠ΅ΡΠ΅ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, ΡΠ²Π»ΡΡΡΠ΅ΠΉΡΡ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π²ΡΠΎΡΠΈΡΠ½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΊΠ°ΠΊ Π²ΠΈΡΡΡΠ½ΠΎΠΉ, ΡΠ°ΠΊ ΠΈ Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΈΡΠΎΠ΄Ρ
Research of a level cytokines-serum patients with the tuberculosis associated from a HIV
In the present work the data of comparative studying the cytokine status (serum concentration and spontaneous production IL-4, IFN-g, TNF-a) at HIV-infected and HIV-non infected persons with the active for the first time revealed tuberculosis, and also an establishment of possible interrelation between these parameters and amount of virus loading, level CD4+T-cell in blood of HIV- infecte patients from TB (group HIV/TB). In process of progressing associated HIV/Π’Π infections and development of heavier forms of TB the increase serum content IFN-g and TNF-a testifying about displacement of balance aside increases proinflammatory cytokines on a background of decrease in number CD4+T-cell, increase of virus loading of a HIV is marked. The received results testify about immunosupreses with an exhaustion of functional reserves mononuclear cells of the peripheral blood aggravated in process of progressing of disease, being one of pathogenetic mechanisms of formation of secondary diseases, both virus, and the bacterial nature