Computing patient data in the cloud: practical and legal considerations for genetics and genomics research in Europe and internationally

Biomedical research is becoming increasingly large-scale and international. Cloud computing enables the comprehensive integration of genomic and clinical data, and the global sharing and collaborative processing of these data within a flexibly scalable infrastructure. Clouds offer novel research opportunities in genomics, as they facilitate cohort studies to be carried out at unprecedented scale, and they enable computer processing with superior pace and throughput, allowing researchers to address questions that could not be addressed by studies using limited cohorts. A well-developed example of such research is the Pan-Cancer Analysis of Whole Genomes project, which involves the analysis of petabyte-scale genomic datasets from research centers in different locations or countries and different jurisdictions. Aside from the tremendous opportunities, there are also concerns regarding the utilization of clouds; these concerns pertain to perceived limitations in data security and protection, and the need for due consideration of the rights of patient donors and research participants. Furthermore, the increased outsourcing of information technology impedes the ability of researchers to act within the realm of existing local regulations owing to fundamental differences in the understanding of the right to data protection in various legal systems. In this Opinion article, we address the current opportunities and limitations of cloud computing and highlight the responsible use of federated and hybrid clouds that are set up between public and private partners as an adequate solution for genetics and genomics research in Europe, and under certain conditions between Europe and international partners. This approach could represent a sensible middle ground between fragmented individual solutions and a “one-size-fits-all” approach

Bacterial Diseases of Wheat in the Southern Ural: Manifestations, Biological Characteristics and Monitoring Features

The paper presents the results of a long-term monitoring of bacterial diseases of wheat in the steppe zone of the Southern Ural. A clear domination of the genus Xanthomonas over the genus Pseudomonas has been revealed (60 and 11% of the total samples collected, respectively). The frequency of a winter wheat infection with these two pathogens exceeded that of the spring wheat. The field phytosanitary assessment resulted in the observation of the earlier unknown manifestation of the Xanthomonas infection called as tip bacteriosis. The frequency of wheat infection with Xanthomonas sp. almost did not depend on the relief type, observation period, and sowing date, though the frequency of infection observed for the northern slope and lowland clearly exceeded those observed for other relief types. The frequency of infection with Pseudomonas sp. clearly depended on the sowing date and local relief type reaching the maximum at the lowlands (19–27%), so this relief type can be considered as a “signal” point for the early diagnostics of this pathogen

Relativistic shock waves in viscous gluon matter

We solve the relativistic Riemann problem in viscous gluon matter employing a microscopic parton cascade. We demonstrate the transition from ideal to viscous shock waves by varying the shear viscosity to entropy density ratio $\eta/s$ from zero to infinity. We show that an $\eta/s$ ratio larger than 0.2 prevents the development of well-defined shock waves on timescales typical for ultrarelativistic heavy-ion collisions. Comparisons with viscous hydrodynamic calculations confirm our findings.Comment: Version as published in PRL 103, 032301 (2009). 4 pages, 4 figure

Investigation of shock waves in the relativistic Riemann problem: A comparison of viscous fluid dynamics to kinetic theory

We solve the relativistic Riemann problem in viscous matter using the relativistic Boltzmann equation and the relativistic causal dissipative fluid-dynamical approach of Israel and Stewart. Comparisons between these two approaches clarify and point out the regime of validity of second-order fluid dynamics in relativistic shock phenomena. The transition from ideal to viscous shocks is demonstrated by varying the shear viscosity to entropy density ratio $\eta/s$. We also find that a good agreement between these two approaches requires a Knudsen number $Kn < 1/2$.Comment: Version as published in PRC 82, 024910 (2010); 16 pages, 16 figures, typos correcte