Особенности патологической анатомии легких при COVID-19

The research aim is to study the morphological features of COVID-19 in the lungs of patients who died in Moscow from March 20 to June 6, 2020. Methods. Autopsy material of the lungs from 123 deceased (54 women, 69 men) with COVID-19 coronavirus infection (confirmed by PCR) was analyzed, the median age was 71 (30 – 94) years, and the duration of the disease was 14 (3 – 65) days. In all cases, the patient’s medical records and autopsy reports were analyzed. Macro- and microscopic changes in the lungs were evaluated in all the observations. Results. The pathology of the lungs in COVID-19 corresponds to various phases of diffuse alveolar damage (DAD). The exudative phase of DAD was detected in 54 (43.9%), the proliferative phase – in 21 (14.63%), and their combination – in 51 (41.46%) of the deceased. Histological features of different phases of DAD are described. Conclusion. An analysis of autopsy material revealed a mismatch between the duration of the course of the disease and the phase of diffuse alveolar damage. A significant portion of the dead found a combination of exudative and proliferative phases of the disease. Histological signs that indirectly indicate a violation of the coagulation system during COVID-19 are described.Целью статьи явилось изучение особенностей морфологических изменений в легких у умерших от COVID-19 в Москве за период 20.03.20–06.06.20. Материалы и методы. Проанализирован аутопсийный материал легких умерших от коронавирусной инфекции COVID-19 больных (n = 123: 54 женщины, 69 мужчин; средний возраст – 71 (30–94) год; продолжительность заболевания – 14 (3–65) суток), подтвержденной методом полимеразной цепной реакции. Проанализированы медицинские карты всех стационарных больных и все протоколы вскрытий. По данным всех наблюдений оценены макро- и микроскопические изменения в легких. Результаты. Патоморфологические изменения в легких соответствовали различным фазам диффузного альвеолярного повреждения (ДАП). Экссудативная фаза ДАП выявлена у 54 (43,9 %), пролиферативная – у 21 (14,63 %), их сочетание – у 51 (41,46 %) умершего. Описаны патогистологические особенности изменений в разные фазы заболевания. Заключение. При анализе аутопсийного материала установлено несоответствие между продолжительностью течения заболевания и фазой ДАП. У значительной части умерших обнаружено сочетание экссудативной и пролиферативной фазы заболевания. Описаны гистологические признаки, косвенно указывающие на нарушение системы коагуляции в течении COVID-19

Measurement of J/ψ→γηcJ/\psi\to\gamma\eta_{\rm c} decay rate and ηc\eta_{\rm c} parameters at KEDR

Using the inclusive photon spectrum based on a data sample collected at the $J/\psi$ peak with the KEDR detector at the VEPP-4M $e^+e^-$ collider, we measured the rate of the radiative decay $J/\psi\to\gamma\eta_{\rm c}$ as well as $\eta_{\rm c}$ mass and width. Taking into account an asymmetric photon lineshape we obtained $\Gamma^0_{\gamma\eta_{\rm c}}=2.98\pm0.18 \phantom{|}^{+0.15}_{-0.33}$ keV, $M_{\eta_{\rm c}} = 2983.5 \pm 1.4 \phantom{|}^{+1.6}_{-3.6}$ MeV/$c^2$, $\Gamma_{\eta_{\rm c}} = 27.2 \pm 3.1 \phantom{|}^{+5.4}_{-2.6}$ MeV.Comment: 6 pages, 3 figure

Precise measurement of RudsR_{\text{uds}} and RR between 1.84 and 3.72 GeV at the KEDR detector

The present work continues a series of the KEDR measurements of the $R$ value that started in 2010 at the VEPP-4M $e^+e^-$ collider. By combining new data with our previous results in this energy range we measured the values of $R_{\text{uds}}$ and $R$ at nine center-of-mass energies between 3.08 and 3.72 GeV. The total accuracy is about or better than $2.6\%$ at most of energy points with a systematic uncertainty of about $1.9\%$. Together with the previous precise $R$ measurement at KEDR in the energy range 1.84-3.05 GeV, it constitutes the most detailed high-precision $R$ measurement near the charmonium production threshold.Comment: arXiv admin note: text overlap with arXiv:1610.02827 and substantial text overlap with arXiv:1510.0266

Measurement of J/psi to eta_c gamma at KEDR

We present a study of the inclusive photon spectra from 5.9 million J/psi decays collected with the KEDR detector at the VEPP-4M e+e- collider. We measure the branching fraction of radiative decay J/psi to eta_c gamma, eta_c width and mass. Our preliminary results are: M(eta_c) = 2979.4+-1.5+-1.9 MeV, G(eta_c) = 27.8+-5.1+-3.3 MeV, B(J/psi to eta_c gamma) = (2.34+-0.15+-0.40)%.Comment: To be published in Proceedings of the PhiPsi09, Oct. 13-16, 2009, Beijing, Chin

Measurement of B(J/psi->eta_c gamma) at KEDR

We present a study of the inclusive photon spectrum from 6.3 million J/psi decays collected with the KEDR detector at the VEPP-4M e+e- collider. We measure the branching fraction of the radiative decay J/psi -> eta_c gamma, eta_c width and mass. Taking into account an asymmetric photon line shape we obtain: M(eta_c) = (2978.1 +- 1.4 +- 2.0) MeV/c^2, Gamma(eta_c) = (43.5 +- 5.4 +- 15.8) MeV, B(J/psi->eta_c gamma) = (2.59 +- 0.16 +- 0.31)%$.Comment: 6 pages, 1 figure. To be published in the proceedings of the 4th International Workshop on Charm Physics (Charm2010), October 21-24, 2010, IHEP, Beijin

Status of VEPP-4M collider: current activity and plans

Presented are the results of a VEPP-4M collider operation at Budker Institute of Nuclear Physics during 2004-2005 as well as the plans for the nearest future.Представлены результаты, полученные на накопителе ВЭПП-4М Института Ядерной физики им. Будкера, за период 2004-2005 г., а также планы на ближайшее будущее.Представлено результати, отримані на накопичувачі ВЕПП-4М Інституту Ядерної фізики ім. Будкера, за період 2004-2005 р., а також плани на найближче майбутн

Measurement of Γee(J/ψ)\Gamma_{ee}(J/\psi) with KEDR detector

The product of the electronic width of the $J/\psi$ meson and the branching fractions of its decay to hadrons and electrons has been measured using the KEDR detector at the VEPP-4M $e^+e^-$ collider. The obtained values are: $\Gamma_{ee}(J/\psi) = 5.550 \pm 0.056 \pm 0.089 \, \text{keV},$ $\Gamma_{ee}(J/\psi) \cdot \mathcal{B}_\text{hadrons}(J/\psi) = 4.884 \pm 0.048 \pm 0.078 \, \text{keV},$ $\Gamma_{ee}(J/\psi) \cdot \mathcal{B}_{ee}(J/\psi) = 0.3331 \pm 0.0066 \pm 0.0040 \, \text{keV}.$ The uncertainties shown are statistical and systematic, respectively. Using the result presented and the world-average value of the electronic branching fraction, one obtains the total width of the $J/\psi$ meson: $\Gamma = 92.94 \pm 1.83 \, \text{keV}.$ These results are consistent with the previous experiments.Comment: 19 pages, 13 figure