Analysis of noise characteristics of multichannel systems of the formation of signals of georadars with synthesized aperture

The noise characteristics of multichannel systems of forming signals based on hybrid frequency synthesizers with automatic compensation of phase distortions of direct digital synthesizers, which are used in the composition of georadars with synthesized aperture, are investigate

The algorithm for solution of the inverse task of the inclinometric control during geotechnical monitoring of the foundation of building

The article discusses the algorithm of the solving of the inverse problem of the determining of the load parameters of foundation during geotechnical monitoring using inclinometric contro

Methodology for estimating the energy reserve of a mobile adhoc communication network with UV-C channel

Communication systems of the solar-blind ultraviolet range UV-C from 200 to 280 nm provide the possibility of communication in the absence of line of sight due to the strong scattering of UV radiation in the atmosphere. For the effective use of UV-C communication systems, an adequate assessment of the energy budget of the UV channel is necessar

AUV Link mobile ad-hoc network examination

Currently, the actual and insufficiently explored direction is the development and research of mobile ad-hoc networks (MANET) with a UV communication channel. To analyze the capacity of a mobile network of UV communications with different spatial orientation of network nodes, it is necessary to take into account not only their coordinates and elevation angles but also azimuth

Measuring angular coordinates in Unmanned Aerial Vehicles (UAVs) positioning systems and developing a new phase-metric method for goniometric control of UAVs

For the safe operation of Unmanned Aerial Vehicles (UAVs), an effective Automatic Control System (ACS) is necessary, which for successful operation requires high accuracy of the initial information about the UAV’s position in space. Based on the analysis of the shortcomings of the known orientation systems, a phase-metric method of goniometric (angular) control based on accelerometric and gyroscopic transducers for positioning the UAV is proposed, which has a higher accuracy and a wider range of measurement angles. The conducted study showed that in a wide range of rotation angles from 10 to 90 degrees, the root mean square error (RMS) of the results of calculating the rotation angle using the phase-metric method is 8,78 times less than the RMS of the results of calculating the rotation angle using the arctangent function. Reducing the error determines the effectiveness of the proposed method in UAV control systems

Effect of dexamethasone therapy on factors of adhesiveness and coagulation in acute lower limb ischemia

Leukocyte-platelet adhesion during hypoxia, tissue damage, activation of inflammation and coagulation is associated with the expression of ICAM-1 membrane molecules and integrins by blood and tissue cells. At the same time, platelet adhesion receptors determine their adhesion to the endothelium and recruited lymphocytes. The role of platelets in the pathogenesis of ischemic cardiovascular diseases also consists in their ability to modulate both hemostasis and inflammatory reactions, which is accompanied by the secretion of inflammatory mediators and factors that promote the recruitment of leukocytes to tissue damage sites. Purpose of the study: to study the effect of the synthetic glucocorticoid dexamethasone on the expression of adhesion receptors CD18+ and CD54+ on leukocytes, the content of platelets and fibrinogen in the blood of patients with ALLI, the relationship of these indicators with the severity and outcome of the disease.To study the effect of anti-inflammatory therapy, a group of 32 patients treated with dexamethasone was formed; the comparison group was represented by 71 patients with basic therapy, the control group consisted of 15 volunteers. After revascularization, all patients received antiplatelet and anticoagulant therapy. Dexamethasone infusions were carried out in a course of 4 to 6 days after reconstructive surgery. In all patients, the content of C-reactive protein in the blood, the content of platelets and fibrinogen were determined. The number of lymphocytes expressing adhesion molecules ICAM-1 (CD54+) and integrins (CD18+) was counted using the immunocytochemical method. Studies were performed before surgery and on days 1, 3, 7, and 10 after surgery.With exacerbation of ischemia and damage to the endothelium, the accumulation of cytolysis products, the expression of adhesion molecules increases both on endotheliocytes and on inflammatory effector cells – leukocytes and platelets. Adhesion molecules conduct an activation signal inside the cell, which promotes adhesion of leukocytes and platelets to the endothelium, lymphocytic-platelet adhesion, the formation of a parietal thrombus, and possible occlusion of damaged vessels. Increased expression of adhesion molecules is associated with the activation of metabolism, inflammation, coagulation and oxidative stress, stimulates all hematopoietic lineages, including platelets. The level of involvement of cellular reactions in the pathogenesis of the disease affects the effectiveness and duration of treatment, the risk of recurrent thrombosis and death. Anti-inflammatory therapy with dexamethasone contributed to earlier remission, a decrease in the proportion of infectious complications, such as wound suppuration from 10% to 6%, the number of necessary amputations from 32% to 16%, the frequency of deaths from 31% to 6%, and a reduction in hospital stay from 13 days to 10.Inflammation, adhesiveness of effector cells and thrombosis are important factors in the pathogenesis of acute lower limb ischemia. Therapy with dexamethasone helps to reduce the level of systemic inflammatory response, the number of necessary amputations, the number of complications and adverse outcomes in the treatment of ALLI, and reduce the length of stay in the hospital

Исследование сравнительной фармакокинетики и биоэквивалентности препаратов Кардиоприл таблетки, 20 мг (АО «Химфарм», Республика Казахстан) и Моноприл® таблетки, 20 мг («Бристол-Майерс Сквибб С.Р.Л.», Италия)

In a single-dose, two-treatment, two-period, two-sequence crossover study with a 1-week washout period was carry out the bioequivalence study of two tablet coated formulation of fosinopril that given to 18 volunteers in equal doses (20 mg). Drug blood plasma concentrations were determined by validated LC-MS method for 48 hours. There were calculated the followed parameters: AUC 0-t ,Cmax, tmax , Cmax /AUC. 90% confidence interval for log-transformed AUC 0-tvalues was 0,9393 - 1,1473 and one for log-transformed Cmax was 0,8861 - 1,066, respectively. It was made the conclusion about bioequivalence of compared fosinopril formulations.В рамках перекрёстного, однократного, открытого, рандомизированного исследования с однонедельным периодом отмывки, с двумя последовательностями была изучена биоэквивалентность двух таблетированных форм фозиноприла на 18 добровольцах (дозировка 20 мг). Образцы плазмы крови анализировали валидированным методом ВЭЖХ-МС/МС в течение 48 часов. Для анализируемых препаратов рассчитаны следующие фармакокинетические параметры: AUC0-t, Cmax, tmax, Cmax/AUC. 90% доверительный интервал для логарифмически преобразованных значений AUC0-t составил 0,9393 - 1,1473 и для Cmax - 0,8861 - 1,066. По результатам исследования был сделан вывод о биоэквивалентности сравниваемых препаратов фозиноприла

Исследования биоэквивалентности Нипезама ретард таблетки, 400 мг (АО «Химфарм», Республика Казахстан) и Финлепсина® 400 ретард таблетки, 400 мг («Плива Краков, Фармацевтическая компания С.А.», Польша)

In a single-dose, two-treatment, two-period, two-sequence crossover study with a 1-month washout period was carry out the bioequivalence study of two tablet coated formulation of carbamazepine that given to 18 volunteers in equal doses (400 mg). Drug blood plasma concentrations were determined by validated LC-UV method for 120 hours. There were calculated the followed parameters: AUC0-t, Cmax , Tmax, Cmax /AUC. 90% confidence interval for log-transformed AUC. values was 0,93693 - 1,10204 and one for log-transformed Cmax was 0,91045 - 1,12287, respectively. It was made the conclusion about bioequivalence of compared carbamazepine formulations.В рамках перекрёстного, однократного, открытого, рандомизированного исследования с одномесячным периодом отмывки, с двумя последовательностями была изучена биоэквивалентность двух таблетированных форм карбамазепина на 18 добровольцах (дозировка 400 мг). Образцы плазмы крови анализировали валидированным методом ВЭЖХ-УФ в течение 120 часов. Для анализируемых препаратов рассчитаны следующие фармакокинетические параметры: AUC0-t, Cmax, Tmax, Cmax/AUC. 90% доверительный интервал для логарифмически преобразованных значений AUC0-t составил 0,93693 - 1,10204 и для Cmax - 0,91045 - 1,12287. По результатам исследования был сделан вывод о биоэквивалентности сравниваемых препаратов карбамазепина

Analysis of noise characteristics of multichannel systems of the formation of signals of georadars with synthesized aperture

The noise characteristics of multichannel systems of forming signals based on hybrid frequency synthesizers with automatic compensation of phase distortions of direct digital synthesizers, which are used in the composition of georadars with synthesized aperture, are investigate

Retracted: The approximation algorithms for analyzing of the dynamic characteristics of the probing signal generators for the geotechnical monitoring systems

This article was withdrawn and retracted by the Journal of Fundamental and Applied Sciences and has been removed from AJOL at the request of the journal Editor in Chief and the organisers of the conference at which the articles were presented (www.iccmit.net). Please address any queries to [email protected]