836 research outputs found
Alien Registration- Hagberg, Carl O. (Saint George, Knox County)
https://digitalmaine.com/alien_docs/13422/thumbnail.jp
Dynamic Front Transitions and Spiral-Vortex Nucleation
This is a study of front dynamics in reaction diffusion systems near
Nonequilibrium Ising-Bloch bifurcations. We find that the relation between
front velocity and perturbative factors, such as external fields and curvature,
is typically multivalued. This unusual form allows small perturbations to
induce dynamic transitions between counter-propagating fronts and nucleate
spiral vortices. We use these findings to propose explanations for a few
numerical and experimental observations including spiral breakup driven by
advective fields, and spot splitting
Controlling domain patterns far from equilibrium
A high degree of control over the structure and dynamics of domain patterns
in nonequilibrium systems can be achieved by applying nonuniform external
fields near parity breaking front bifurcations. An external field with a linear
spatial profile stabilizes a propagating front at a fixed position or induces
oscillations with frequency that scales like the square root of the field
gradient. Nonmonotonic profiles produce a variety of patterns with controllable
wavelengths, domain sizes, and frequencies and phases of oscillations.Comment: Published version, 4 pages, RevTeX. More at
http://t7.lanl.gov/People/Aric
Order Parameter Equations for Front Transitions: Planar and Circular Fronts
Near a parity breaking front bifurcation, small perturbations may reverse the
propagation direction of fronts. Often this results in nonsteady asymptotic
motion such as breathing and domain breakup. Exploiting the time scale
differences of an activator-inhibitor model and the proximity to the front
bifurcation, we derive equations of motion for planar and circular fronts. The
equations involve a translational degree of freedom and an order parameter
describing transitions between left and right propagating fronts.
Perturbations, such as a space dependent advective field or uniform curvature
(axisymmetric spots), couple these two degrees of freedom. In both cases this
leads to a transition from stationary to oscillating fronts as the parity
breaking bifurcation is approached. For axisymmetric spots, two additional
dynamic behaviors are found: rebound and collapse.Comment: 9 pages. Aric Hagberg: http://t7.lanl.gov/People/Aric/; Ehud Meron:
http://www.bgu.ac.il/BIDR/research/staff/meron.htm
Changes in Circulating Angiogenic Cell Number and Function During and After an Ultramarathon
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Benefit of pazopanib in advanced gastrointestinal stromal tumours : results from a phase II trial (SSG XXI, PAGIST)
Background: Patients with advanced gastrointestinal stromal tumours (GISTs) resistant to the tyrosine kinase inhibitors imatinib and sunitinib may be treated with regorafenib, which resulted in a median progression-free survival (PFS) of 4.8 months in the GRID trial. Also, pazopanib, another tyrosine kinase inhibitor, has been studied in a randomized, placebo-controlled trial (PAZOGIST) in the third line, which showed a PFS of 45.2% 4 months after study entry, but patients intolerant to sunitinib were also included. We designed another trial evaluating pazopanib, enrolling only patients with progression on both imatinib and sunitinib. Patients and methods: Since all eligible patients had progressive disease, we preferred a non-randomized, phase II multicentre trial so that all patients could receive a potentially active drug. Patients had a progressive metastatic or locally advanced GIST and were >= 18 years of age, with a performance status of 0-2, and sufficient organ functions. The primary endpoint was disease control rate (defined as complete remission thorn partial remission thorn stable disease) at 12 weeks on pazopanib. A Simon's two-stage analysis was used with an interim analysis 12 weeks after enrollment of the first 22 patients, and if passed, there was a full enrolment of 72 patients. GIST mutational analysis was done, and most patients had pazopanib plasma concentration measured after 12 weeks. Results: Seventy-two patients were enrolled. The disease control rate after 12 weeks was 44%, and the median PFS was 19.6 weeks (95% confidence interval 12.6-23.4 weeks). Pazopanib-related toxicity was moderate and manageable. No statistically significant differences were found related to mutations. Plasma concentrations of pazopanib had a formal but weak correlation with outcome. Conclusion: Pazopanib given in the third line to patients with GIST progressing on both imatinib and sunitinib was beneficial for about half of the patients. The PAGIST trial confirms the results from the PAZOGIST trial, and the median PFS achieved seems comparable to the PFS achieved with regorafenib in the third-line setting.Peer reviewe
A preferential attachment model with random initial degrees
In this paper, a random graph process is studied and its
degree sequence is analyzed. Let be an i.i.d. sequence. The
graph process is defined so that, at each integer time , a new vertex, with
edges attached to it, is added to the graph. The new edges added at time
t are then preferentially connected to older vertices, i.e., conditionally on
, the probability that a given edge is connected to vertex i is
proportional to , where is the degree of vertex
at time , independently of the other edges. The main result is that the
asymptotical degree sequence for this process is a power law with exponent
, where is the power-law exponent
of the initial degrees and the exponent predicted
by pure preferential attachment. This result extends previous work by Cooper
and Frieze, which is surveyed.Comment: In the published form of the paper, the proof of Proposition 2.1 is
incomplete. This version contains the complete proo
Streaming instability of slime mold amoebae: An analytical model
During the aggregation of amoebae of the cellular slime mould Dictyostelium, the interaction of chemical waves of the signaling molecule cAMP with cAMP-directed cell movement causes the breakup of a uniform cell layer into branching patterns of cell streams. Recent numerical and experimental investigations emphasize the pivotal role of the cell-density dependence of the chemical wave speed for the occurrence of the streaming instability. A simple, analytically tractable, model of Dictyostelium aggregation is developed to test this idea. The interaction of cAMP waves with cAMP-directed cell movement is studied in the form of coupled dynamics of wave front geometries and cell density. Comparing the resulting explicit instability criterion and dispersion relation for cell streaming with the previous findings of model simulations and numerical stability analyses, a unifying interpretation of the streaming instability as a cAMP wave-driven chemotactic instability is proposed
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