The Current Status of Work Integration Social Enterprises in the European Union: From the Point of View of a Critical Analysis on Social Enterprises

This paper focuses on work integration social enterprises (WISEs) in the European Union. First it clarifies the issues of social enterprises. Second it reviews WISEs. There are various types of WISEs. Thisstudy shows how we can categorise them. Finally，it explains the issues of WISEs.　EUにおける労働統合を目的とした社会的企業 (work integration social enterprise: WISE) を取り上げる。最初に、社会的企業論の論点を明らかにする。次に、WISEについて検討する。WISEには多様な形態がある。多様なWISEの形態がどのように分類されるかを示す。 最後に、WISEに関する論点を説明する

Methodological approaches of formation of evaluative indicators of quality of life

© 2014, Mediterranean Center of Social and Educational Research. All rights reserved. The article deals with methodological approaches for the essence of quality of life. More precise definition of conceptual framework and definition of the notion of quality of life. The components of quality if life, such as, for example, the level of education, social integration and social consensus, health, life time, security assurance, etc., are described. It is shown that the paradigm of human life and activities which is understood as continuous interaction of individual with his inner and outer world in order to sustain his existence, to pursue abilities and opportunities of a person, is in the basis of the notion of quality of life. Evaluative indicators of quality of life are given. Economic development and quality of life mutually reinforce each other. Actually, they are the elements of one paradigm. Quality of life is the instrument of economic transformations and structural changes

Опыт сочетания полного парентерального питания с противоопухолевым лечением у больного с метастатическим колоректальным раком

Pathologic nutrients metabolism presents a severe problem in metastatic colorectal cancer patients, especially those with canceromatosis. A hypermetabolism-catabolism syndrome frequently develops in in patients with progressing canceromatosis. This leads to cachexia anorexia syndrome, which significantly impedes available treatment options. Artificial nutrition allows to improve available treatment in such patients. We present a successful case of concomitant parenteral nutrition and systemic cytotoxic therapy in metastatic colorectal cancer patient with peritoneal canceromatosis.Патологическая направленность обмена веществ является серьезной проблемой у больных метастатическим колоректальным раком (КРР), имеющих канцероматоз брюшины. В условиях прогрессирующего опухолевого процесса у больных с поражением брюшины нередко развивается синдром гиперметаболизма-катаболизма. Это приводит к развитию синдрома кахексии-анорексии, значительно усложняющего проведение лечебных мероприятий. Применение искусственного питания позволяет расширить объем проводимой противоопухолевой терапии. Коллективом авторов представлен случай успешного применения искусственного питания в сочетании с активной противоопухолевой терапией у больного метастатическим КРР с канцероматозом брюшины

Факторы, ассоциированные с эффективностью комбинации FOLFIRI и афлиберцепта при метастатическом раке толстой кишки

Objective: to identify factors associated with efficacy of an aflibercept-chemotherapy combination in patients with metastatic colon cancer.Materials and methods. This retrospective multicenter study was conducted in 20 clinics from 15 regions of the Russian Federation. The main efficacy outcome was progression-free survival (PFS). We performed univariate and multivariate analysis to assess the impact of various factors of PFS.Results. Two hundred and fifty-seven patients received aflibercept-containing chemotherapy; of them, 175 participants (68.1 %) received it as a second-line therapy. The objective response rate and median PFS were 18.7% and 5 months (95% confidence interval (CI) 4.2—5.8) respec -tively. The following factors were found to have a positive effect of PFS at multivariate analysis: grade I—II adverse events to aflibercept therapy (hazard ratio (HR) 0.58; 95 % CI 0.38—0.89; p = 0.01), therapy for concomitant diseases (HR 0.47; 95 % CI 0.29—0.76; p = 0.002), and ECOG performance status of 0 (HR 0.53; 95 % CI 0.34—0.81; p = 0.004). Patient with all 3 factors present had median PFS of 9 months, whereas patients without them demonstrated PFS of only 3 months (HR 1.9; 95 % CI 1.5—2.6; p <0.001).Conclusions. Satisfactory performance status, adequate therapy for concomitant diseases, and adverse events to aflibercept therapy were associated with better PFS in patients receiving aflibercept-containing chemotherapy.Цель исследования — выявить факторы, ассоциированные с эффективностью комбинации химиотерапии и афлиберцепта у больных метастатическим раком толстой кишки.Материалы и методы. Проведено ретроспективное многоцентровое исследование. Собраны данные 20 клиник из 15 регионов Российской Федерации. В качестве основного критерия эффективности рассматривали выживаемость без прогрессирования (ВБП). Был проведен одно- и многофакторный анализ влияния различных признаков на ВБП.Результаты. Двести пятьдесят семь пациентов получали терапию с включением афлиберцепта, в том числе во 2-й линии — 175 (68,1 %) больных. Объективный эффект и медиана ВБП составили 18,7 % и 5 мес (95 % доверительный интервал (ДИ) 4,2—5,8) соответственно. По результатам многофакторного анализа благоприятными факторами прогноза в отношении ВБП выступали развитие побочных явлений I—II степени тяжести при терапии афлиберцептом (отношение рисков (ОР) 0,58; 95 % ДИ 0,38—0,89; p = 0,01), назначение терапии по поводу сопутствующих заболеваний (ОР 0,47; 95 % ДИ 0,29—0,76; p = 0,002) и функциональный статус пациента ECOG 0 (ОР 0,53; 95 % ДИ 0,34—0,81; p = 0,004). При наличии всех 3 факторов медиана ВБП составила 9 мес, при их отсутствии — 3 мес (ОР 1,9; 95 % ДИ 1,5—2,6; p <0,001).Выводы. Удовлетворительный функциональный статус пациента, медикаментозный контроль сопутствующей патологии и развитие нежелательных явлений в процессе терапии афлиберцептом ассоциированы с улучшением ВБП в популяции пациентов, которым проводится терапия с включением афлиберцепта

Investigation of the supply chain management effects on tourism infrastructure in the region as a competitive factor

© ExcelingTech Pub, UK. In this paper the components of tourism infrastructure were investigated by considering the supply chain management effects. One of the most important components of tourism infrastructure is the hotel industry. In recent years, the quantity of means of collective placement in the Republic of Tatarstan increased. In the republic, means of placement of almost all categories are presented, among them there are also representatives of such large hotel chains as Hilton, Marriott, ark Inn, Ramada, Ibis. The food industry is also an integral part of tourism infrastructure of the region. The show business of the Republic of Tatarstan covers a huge range of opportunities for visitors, beginning with excursion tours on historical, architectural and cultural sights, finishing with a possibility of visit of various festivals. Today the most important component of tourist infrastructure is transport infrastructure. Its importance and the importance is that first of all for the tourist it is necessary quickly and with comfort to reach a certain destination. Often an opportunity without special waste of time to reach the appointed place acts as criterion for selection of the place of a trip. As for the Republic of Tatarstan, it possesses an extensive transport network and includes all means of transport. The advantageous geographical location also contributes to the development of transport infrastructure. Public authorities of the republic also pay attention to development of the transport system. The Ministry of Transport and Road Facilities of the Republic of Tatarstan adopted the State program "Development of the transport system to the Republic of Tatarstan for 2014 - 2022" which purpose is ensuring further development and creation of a modern transport complex. Tourism in the Republic of Tatarstan in recent years became one of the most dynamically developing branches of economy. Carrying out a large number of actions of the international level and favorable investment climate allowed the republic to come to the leading position in development of tourism in the Russian Federation

The main directions of supply chain management development of territorial branding in Russia in modern conditions

© ExcelingTech Pub, UK. In article the most important directions of development of territorial branding in Russia are considered based on the supply chain management. Importance and relevance of consideration of the matter taking into account strengthening of competition between regions and need of increase in their competitiveness is shown. Author's definitions of a territorial brand and territorial branding are given. Classification of the Russian territorial brands on the basis of population, living in the respective territory, in the city or the rural settlement was carried out. Authors give a large number of the illustrations opening the maintenance of territorial brands and disclose the main ideas which are been the basis for their designing. In conclusion of article the conclusion was drawn that development and advance of territorial brands significantly increases tourist and recreational and investment attractiveness of regions, and, therefore, promotes acceleration of rates of their social and economic development and improvement of quality of life of local population

The main directions of supply chain management development of territorial branding in Russia in modern conditions

© ExcelingTech Pub, UK. In article the most important directions of development of territorial branding in Russia are considered based on the supply chain management. Importance and relevance of consideration of the matter taking into account strengthening of competition between regions and need of increase in their competitiveness is shown. Author's definitions of a territorial brand and territorial branding are given. Classification of the Russian territorial brands on the basis of population, living in the respective territory, in the city or the rural settlement was carried out. Authors give a large number of the illustrations opening the maintenance of territorial brands and disclose the main ideas which are been the basis for their designing. In conclusion of article the conclusion was drawn that development and advance of territorial brands significantly increases tourist and recreational and investment attractiveness of regions, and, therefore, promotes acceleration of rates of their social and economic development and improvement of quality of life of local population

Methodological approaches of formation of evaluative indicators of quality of life

© 2014, Mediterranean Center of Social and Educational Research. All rights reserved. The article deals with methodological approaches for the essence of quality of life. More precise definition of conceptual framework and definition of the notion of quality of life. The components of quality if life, such as, for example, the level of education, social integration and social consensus, health, life time, security assurance, etc., are described. It is shown that the paradigm of human life and activities which is understood as continuous interaction of individual with his inner and outer world in order to sustain his existence, to pursue abilities and opportunities of a person, is in the basis of the notion of quality of life. Evaluative indicators of quality of life are given. Economic development and quality of life mutually reinforce each other. Actually, they are the elements of one paradigm. Quality of life is the instrument of economic transformations and structural changes

Cluster approach for development of tourism infrastructure based on the supply chain management in the region

© ExcelingTech Pub, UK. In article authors describe value of tourism infrastructure in the region. Tourism infrastructure is a complex system which consists of a set of elements of various branch accessory. Uniform development of each element is possible only thanks to the supply chain management. Owing to the complexity, tourism infrastructure and its components are an object of regional government. The instrument of development of tourist infrastructure is adoption of various programs of development of tourism in regions. Authors believe that a perspective way of development of tourism infrastructure of the region and in general the tourist industry is creation of a tourist cluster. The tourist cluster represents the merging of the enterprises of various sectors serving clients concentrated in a certain territory, and also investments and innovations. Hotels, food objects, tourist operators and tourist agents, transport enterprises, entertainment complexes can treat such enterprises. The purpose of creation of tourist clusters is improving competitiveness and formation of image of the region in the tourist market thanks to effective work of the organizations and enterprises entering a cluster. The main essence of a cluster - an opportunity for business and for the region to develop not by inertia. Tourist clusters are formed on the basis of operation of the mechanism of public-private partnership and scientifically based decisions that allows to create the best conditions for development of tourism infrastructure and related services. Along with development of tourism infrastructure, cluster approach allows to stir up activity of the regional enterprises of the different branches of economy for satisfaction of the growing needs for high-quality tourist services at increase in regional tourist streams