Vital Functions Contribute to the Spread of Extracellular Fluids in the Brain: Comparison Between Life and Death

Vascular pulsations, contractions of vascular smooth muscle cells and breathing have been reported to foster movement and clearance of interstitial and cerebrospinal fluids from the brain. The aim of this study was to estimate the contribution of these vital functions. We compared the spread of an injected hydrophilic tracer (Fluoro-Emerald, a 10 kDa fluorescein-coupled dextran amine) in the brains of live anesthetized and sacrificed rats at 30 and 90 min after injection. To determine the overall pattern of distribution of tracers, we created 3D-reconstructions of the horizontal transections of the whole brain. Immunofluorescence staining with laminin and collagen IV was performed to determine the pattern of distribution of tracer in relation to the cerebrovascular basement membranes. We found that diffusion was widely restricted to the periventricular region in sacrificed rats with no spread to the contralateral hemisphere, while the bulk flow occurred along the vasculature and reached the surface and the contralateral hemisphere as soon as 30 min after injection in live anesthetized animals. The tracer appeared to be localized along the vascular basement membranes and along fiber tracts as reported previously. Thus, our data indicate that vital functions are essential for the remote movement of extracellular fluids within the cerebral parenchyma

Black Hole--Scalar Field Interactions in Spherical Symmetry

We examine the interactions of a black hole with a massless scalar field using a coordinate system which extends ingoing Eddington-Finkelstein coordinates to dynamic spherically symmetric-spacetimes. We avoid problems with the singularity by excising the region of the black hole interior to the apparent horizon. We use a second-order finite difference scheme to solve the equations. The resulting program is stable and convergent and will run forever without problems. We are able to observe quasi-normal ringing and power-law tails as well an interesting nonlinear feature.Comment: 16 pages, 26 figures, RevTex, to appear in Phys. Rev.

No-go theorem for false vacuum black holes

We study the possibility of non-singular black hole solutions in the theory of general relativity coupled to a non-linear scalar field with a positive potential possessing two minima: a `false vacuum' with positive energy and a `true vacuum' with zero energy. Assuming that the scalar field starts at the false vacuum at the origin and comes to the true vacuum at spatial infinity, we prove a no-go theorem by extending a no-hair theorem to the black hole interior: no smooth solutions exist which interpolate between the local de Sitter solution near the origin and the asymptotic Schwarzschild solution through a regular event horizon or several horizons.Comment: 16 pages, 1 figure, Latex, some references added, to appear in Classical and Quantum Gravit

Fidelity trade-off for finite ensembles of identically prepared qubits

We calculate the trade-off between the quality of estimating the quantum state of an ensemble of identically prepared qubits and the minimum level of disturbance that has to be introduced by this procedure in quantum mechanics. The trade-off is quantified using two mean fidelities: the operation fidelity which characterizes the average resemblance of the final qubit state to the initial one, and the estimation fidelity describing the quality of the obtained estimate. We analyze properties of quantum operations saturating the achievability bound for the operation fidelity versus the estimation fidelity, which allows us to reduce substantially the complexity of the problem of finding the trade-off curve. The reduced optimization problem has the form of an eigenvalue problem for a set of tridiagonal matrices, and it can be easily solved using standard numerical tools.Comment: 26 pages, REVTeX, 2 figures. Few minor corrections, accepted for publication in Physical Review

Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL

Here, we provide evidence for a detrimental role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in neural death in T cell-induced experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Clinical severity and neuronal apoptosis in brainstem motor areas were substantially reduced upon brain-specific blockade of TRAIL after induction of EAE through adoptive transfer of encephalitogenic T cells. Furthermore, TRAIL-deficient myelin-specific lymphocytes showed reduced encephalitogenicity when transferred to wild-type mice. Conversely, intracerebral delivery of TRAIL to animals with EAE increased clinical deficits, while naive mice were not susceptible to TRAIL. Using organotypic slice cultures as a model for living brain tissue, we found that neurons were susceptible to TRAIL-mediated injury induced by encephalitogenic T cells. Thus, in addition to its known immunoregulatory effects, the death ligand TRAIL contributes to neural damage in the inflamed brain

Quantum Distribution of Gaussian Keys with Squeezed States

A continuous key distribution scheme is proposed that relies on a pair of canonically conjugate quantum variables. It allows two remote parties to share a secret Gaussian key by encoding it into one of the two quadrature components of a single-mode electromagnetic field. The resulting quantum cryptographic information vs disturbance tradeoff is investigated for an individual attack based on the optimal continuous cloning machine. It is shown that the information gained by the eavesdropper then simply equals the information lost by the receiver.Comment: 5 pages, RevTe

Parity proofs of the Bell-Kochen-Specker theorem based on the 600-cell

The set of 60 real rays in four dimensions derived from the vertices of a 600-cell is shown to possess numerous subsets of rays and bases that provide basis-critical parity proofs of the Bell-Kochen-Specker (BKS) theorem (a basis-critical proof is one that fails if even a single basis is deleted from it). The proofs vary considerably in size, with the smallest having 26 rays and 13 bases and the largest 60 rays and 41 bases. There are at least 90 basic types of proofs, with each coming in a number of geometrically distinct varieties. The replicas of all the proofs under the symmetries of the 600-cell yield a total of almost a hundred million parity proofs of the BKS theorem. The proofs are all very transparent and take no more than simple counting to verify. A few of the proofs are exhibited, both in tabular form as well as in the form of MMP hypergraphs that assist in their visualization. A survey of the proofs is given, simple procedures for generating some of them are described and their applications are discussed. It is shown that all four-dimensional parity proofs of the BKS theorem can be turned into experimental disproofs of noncontextuality.Comment: 19 pages, 11 tables, 3 figures. Email address of first author has been corrected. Ref.[5] has been corrected, as has an error in Fig.3. Formatting error in Sec.4 has been corrected and the placement of tables and figures has been improved. A new paragraph has been added to Sec.4 and another new paragraph to the end of the Appendi

Parity proofs of the Kochen-Specker theorem based on the 24 rays of Peres

A diagrammatic representation is given of the 24 rays of Peres that makes it easy to pick out all the 512 parity proofs of the Kochen-Specker theorem contained in them. The origin of this representation in the four-dimensional geometry of the rays is pointed out.Comment: 14 pages, 6 figures and 3 tables. Three references have been added. Minor typos have been correcte

Controlling passively-quenched single photon detectors by bright light

Single photon detectors based on passively-quenched avalanche photodiodes can be temporarily blinded by relatively bright light, of intensity less than a nanowatt. I describe a bright-light regime suitable for attacking a quantum key distribution system containing such detectors. In this regime, all single photon detectors in the receiver Bob are uniformly blinded by continuous illumination coming from the eavesdropper Eve. When Eve needs a certain detector in Bob to produce a click, she modifies polarization (or other parameter used to encode quantum states) of the light she sends to Bob such that the target detector stops receiving light while the other detector(s) continue to be illuminated. The target detector regains single photon sensitivity and, when Eve modifies the polarization again, produces a single click. Thus, Eve has full control of Bob and can do a successful intercept-resend attack. To check the feasibility of the attack, 3 different models of passively-quenched detectors have been tested. In the experiment, I have simulated the intensity diagrams the detectors would receive in a real quantum key distribution system under attack. Control parameters and side effects are considered. It appears that the attack could be practically possible.Comment: Experimental results from a third detector model added. Minor corrections and edits made. 11 pages, 10 figure