Tetrabenzylcyclen as a receptor for fluoride

A tetraazacyclic ligand, tetrabenzylcyclen (L), was synthesized using an improved method with a higher yield by treatment of cyclen with benzylchloride in the presence of potassium carbonate. The reaction of L with an aqueous solution of fluorosilicic acid yielded a mixed-anionic salt with the composition [H3L][F][SiF6]$4H2O (1). The single crystal X-ray study revealed that the macrocyclic trication essentially changes the conformation compared to the free ligand in order to tightly accommodate the fluoride inside and to keep the hexafluorosilicate anions and water molecules outside in the solid state complex

Extensive penile skin necrosis after surgery for Peyronie's disease

The clinical case represents the surgical correction of postoperative complications in a patient with Peyronie's disease. The patient underwent flap corporoplasty using an autovein. The late postoperative period in the patient was complicated by extensive necrosis of the penile skin, which required repeated surgery as follows. The first stage of surgical treatment was performed by excision of necrotic tissues of the penile skin. Within 10 days of the postoperative period, chymotrypsin with an ointment containing dioxomethyltetrahydropyrimidine with chloramphenicol was applied to the penile wound surface to prepare the wound for subsequent skin autotransplantation. Further, within 5 days, the polymeric drainage sorbent «Aseptisorb DT» was applied to the wound surface until the wound was cleansed and granulation tissue was formed. The second stage of the surgical treatment performed penile skin replacement plasty with a free perforated skin graft taken from the patient's femoral surface

Percutaneous cystolithotripsy for patients with benign prostatic hyperplasia

Introduction. According to the literature, 5.0% of patients with urolithiasis are characterized by the presence of stones in the bladder. The issue of bladder stones for patients with benign prostatic hyperplasia remains relevant and requires further improvement of approaches to surgical treatment.Purpose of the study. To evaluate the safety and efficacy of energy-diverse percutaneous cystolithotripsy (and placement of a cystostomy catheter) in comparison with transurethral cystolithotripsy.Materials and methods. A retrospective analysis of 56 cases in patients (aged 54-82 years) with bladder stones was carried out. All patients were treated in the Urology Clinic of the Mechnikov North-Western State Medical University from 2019 to 2021. Two groups were formed: group I — 26 (46.4%) patients who underwent percutaneous cystolithotripsy, group II — 30 (53.6%) patients underwent transurethral cystolithotripsy. The duration of surgery, intraoperative and postoperative complications were assessed.Results. On average, the duration of surgery for the percutaneous approach was shorter than for transurethral access (35 vs 44 min). The stone-free rate in the case of the percutaneous approach was 100.0%, while in transurethral cystolithotripsy the stone-free rate was 90.0%. In the early postoperative period, in groups I and II, gross hematuria was observed for 2 (7.6%) and 4 (13.3%) patients, respectively. In the late postoperative period, 2 patients from group II had a urethral stricture.Conclusions. Percutaneous cystolithotripsy is a minimally invasive method of stone fragmentation, characterized by a minimal risk of intra- and postoperative complications

Энергетическое обследование здания и исследование его системы теплопотребления

У статті представлено результати спрощеного енергетичного обстеження адміністративної будівлі. Проведений розрахунок середніх річних питомих тепловитрат на опалення будівлі та визначено доцільність впровадження комплексу заходів щодо зменшення споживання теплової енергії шляхом встановлення індивідуального теплового пункту.The article presents the results of the energy audit of the administrative building. The calculation of average annual specific heat loss of the building heating was conducted and the feasibility of a set of measures to reduce the consumption of thermal energy, by establishing individual heat point was determined.В статье представлены результаты энергетического обследования административного здания. Проведенный расчет средних годовых удельных теплопотерь на отопление здания и определена целесообразность внедрения комплекса мероприятий по уменьшению потребления тепловой энергии путем установления индивидуального теплового пункта

[Introduction] The making and unmaking of precarious, ideal subjects – migration brokerage in the Global South

The migration literature is often underpinned by the idea that migrants are either completely ‘free’ agents, individually choosing how best to achieve returns on their human capital and resources (Sjaastad 1962) or ‘agents of development’ for their home countries and regions (Turner and Kleist 2013). Conversely they are viewed as exploited slaves, being pushed into low-paid occupations and controlled by middlemen and employers. Unsurprisingly, in many close-knit societies a process as expensive and life-defining as migration is rarely undertaken as an individual act and is shaped by complex social interactions within kinship networks and beyond (Lindquist 2012). Brokerage is ever-present in migrant labour markets around the world, variously interpreted as occupying the ‘middle space’ between migrants and the state, helping migrants navigate complex immigration regimes (Lindquist, Xiang, and Yeoh 2012; McKeown 2012; Schapendonk 2017), acting as an extension of the state seeking to outsource border controls (Goh, Wee, and Yeoh 2017) and colluding with employers to cheapen and commoditise migrant labour (Guérin 2013; McCollum and Findlay 2018). It is increasingly recognised that an understanding of contemporary migration is not complete without an understanding of the mediating practices that facilitate and constrain it (Coe and Jordhus-Lier 2011; Cranston, Schapendonk, and Spaan 2018). This special issue investigates the role that migration brokers play in the subjectivation and precarisation of migrant men and women from marginalised classes and ethnicities in the Global South. It shows how these processes are critical for them to become a part of contemporary economic and political systems of international and internal labour circulation. It responds to the call of labour geographers for a deeper understanding of the ways in which diverse economic and social contexts result in complex forms of precarity (McDowell 2015) and adds to the evidence on the role of actors beyond the workplace in co-creating precarity (Buckley, McPhee, and Rogaly 2017)

О возможности терапевтического действия после окончания аппликации трансдермальной системы доставки лекарственных веществ

Background. As scientific knowledge about the peculiarities of the structure and functional properties of the skin increased, it became clearer that during transdermal administration, drug may accumulate in the deep layers of the dermis and subsequently get diffused into the bloodstream even after the transdermal therapeutic system (TTS), also called transdermal patch, had been removed. Objective: to quantify active drug substances remaining in an animal skin after TTS application. Materials and methods. Two previously developed transdermal patches containing Russian-made drug substances were chosen for the study: aminodihydrophthalazinedione sodium (immunomodulator) and bis(1-vinylimidazole-N) zinc diacetate (antidote for carbon monoxide). The study was performed on male Chinchilla rabbits weighing 2.5–3 kg. Five series of experiments were performed for each substance: immediately after removal of the patch, 4 hours later, at week 1, 2 and 3 after removal. High-performance liquid chromatography and atomic absorption spectroscopy methods were used to quantify residual drug substances left in the skin. Results. In the skin flap that was in contact with the aminodihydrophthalazinedione sodium TTS for 24 hours, 0.516 mg of the drug was detected immediately after removal of the patch. Over the next two weeks, the drug substance in the skin decreased with the immunomodulator significantly reducing to 0.41 mg in the first 4 hours. In the skin flap that had been in contact with zinc bis(1-vinylimidazole-N) diacetate for 24 hours, about 1 mg of the drug was present immediately after patch removal. Four hours after removal of the transdermal patch, the quantity of active substance in the skin remained practically unchanged. At week 1 and 2, the quantity of the antidote decreased slightly to ~0.7 mg and ~0.25 mg, respectively. Conclusion. For transdermal application of aminodihydrophthalazinedione sodium, the skin can act as a drug depot and prolong the effect of this drug even after the transdermal patch had been removed. No such effect was found in the case of bis(1-vinylimidazole-N) zinc diacetate, which is apparently due to the different solubility of the drugs in the biotissue.Введение. По мере развития научных знаний об особенностях структуры и функциональных свойств кожи стало понятно, что при чрескожном введении существует вероятность накопления лекарственных веществ в глубоких слоях дермы с последующей их диффузией в кровоток даже после снятия трансдермальной терапевтической системы (ТТС). Целью данной работы явилось установление наличия остаточного количества лекарственного вещества в коже животного после применения трансдермальной терапевтической системы. Материалы и методы. Для исследования выбраны две разработанные ранее ТТС, содержащие отечественные лекарственные субстанции: аминодигидрофталазиндион натрия (иммуномодулятор) и диацетат бис(1-винилимидазол-N) цинка (антидот угарного газа). Исследование проводили на кроликахсамцах породы Шиншилла массой 2,5–3 кг. Для каждой субстанции было выполнено пять серий экспериментов: непосредственно после открепления ТТС, через 4 часа, одну, две и три недели после удаления лекарственной формы. Для определения остаточного количества лекарственных веществ в коже были использованы методы высокоэффективной жидкостной хроматографии и атомно-адсорбционного анализа. Результаты. В кожном лоскуте, контактировавшем с ТТС аминодигидрофталазиндиона натрия в течение 24 часов, сразу после ее открепления присутствовало 0,516 мг лекарственного вещества. На протяжении последующих двух недель наблюдалось снижение содержания лекарственного вещества в коже, причем существенное уменьшение количества иммуномодулятора происходило уже в первые 4 часа и составило 0,41 мг. В кожном лоскуте, контактировавшем с ТТС диацетат бис(1-винилимидазол-N) цинка в течение 24 часов, сразу после ее открепления лекарственное вещество присутствовало в количестве примерно 1 мг. Через 4 часа после удаления ТТС количество активного вещества в коже практически не изменилось. Через одну и две недели количество антидота незначительно снижалось и составило ~0,7 мг и ~0,25 мг соответственно. Заключение. Полученные результаты по чрескожному введению аминодигидрофталазиндиона натрия показали, что кожа может выступать в качестве депо лекарственного вещества и пролонгировать его действие даже после снятия ТТС. В случае с диацетат бис(1-винилимидазол-N) цинка такого эффекта обнаружено не было, что связано, по-видимому, с разной растворимостью исследуемых лекарственных веществ в биоткани

Measurement of J/ψ→γηcJ/\psi\to\gamma\eta_{\rm c} decay rate and ηc\eta_{\rm c} parameters at KEDR

Using the inclusive photon spectrum based on a data sample collected at the $J/\psi$ peak with the KEDR detector at the VEPP-4M $e^+e^-$ collider, we measured the rate of the radiative decay $J/\psi\to\gamma\eta_{\rm c}$ as well as $\eta_{\rm c}$ mass and width. Taking into account an asymmetric photon lineshape we obtained $\Gamma^0_{\gamma\eta_{\rm c}}=2.98\pm0.18 \phantom{|}^{+0.15}_{-0.33}$ keV, $M_{\eta_{\rm c}} = 2983.5 \pm 1.4 \phantom{|}^{+1.6}_{-3.6}$ MeV/$c^2$, $\Gamma_{\eta_{\rm c}} = 27.2 \pm 3.1 \phantom{|}^{+5.4}_{-2.6}$ MeV.Comment: 6 pages, 3 figure

The structure of infant mortality under 6 months of age in the Sverdlovsk region for the period 2016-2017 according to the findings of forensic medical examination.

The article presents a statistical analysis of data on the structure of child mortality in the Sverdlovsk region for the period 2016-2017. Data analysis revealed the main causes of death among children, the study was conducted on the basis of a forensic report using modern statistical methods.Статья содержит статистический анализ данных о структуре детской смертности на территории Свердловской области за 2016-2017 год. Анализ данных позволил выявить основные причины смерти детей до 6 месяцев. Исследование проведено на основании изучения судебномедицинских протоколов вскрытий с использованием современных статистических методик

Measurement of B(J/psi->eta_c gamma) at KEDR

We present a study of the inclusive photon spectrum from 6.3 million J/psi decays collected with the KEDR detector at the VEPP-4M e+e- collider. We measure the branching fraction of the radiative decay J/psi -> eta_c gamma, eta_c width and mass. Taking into account an asymmetric photon line shape we obtain: M(eta_c) = (2978.1 +- 1.4 +- 2.0) MeV/c^2, Gamma(eta_c) = (43.5 +- 5.4 +- 15.8) MeV, B(J/psi->eta_c gamma) = (2.59 +- 0.16 +- 0.31)%$.Comment: 6 pages, 1 figure. To be published in the proceedings of the 4th International Workshop on Charm Physics (Charm2010), October 21-24, 2010, IHEP, Beijin