THE CHOICE OF EFFECTIVE TYPES OF VIRTUAL ORGANIZATIONS FOR THE AEROSPACE INDUSTRY

Methodological postulates that allow to raise the issue of the formation of virtual organizations in the aerospace industry in the context of corporate structures and material, mainly assets - are formulated. The classication scheme of basic virtual organizations, based on the analysis of conceptual directions of information integration, has been claried. The author’s version of the hierarchical classication scheme of virtual organizations is considered. The recommendations on the forms of virtual organizations based on the selection of the most appropriate aerospace industry from the presented classication scheme of virtualization forms are formulated

SUGGESTIONS ON THE APPLICATION OF CLUSTER TECHNOLOGIES AT THE MODERN STAGE OF DEVELOPMENT OF THE ECONOMY OF THE CITY OF MOSCOW

The issues of creating and functioning cluster structures within the territory of the city of Moscow in various fields of activity and providing them with the appropriate infrastructure have been examined. The role of clusters in the field of strengthening cooperative ties in order to implement mutually beneficial business projects has been emphasized. Practical recommendations have been given, within the framework of the current regulatory and legal framework, on the creation of a rational system, that allows organizing selection into a cluster of business entities. Particular attention has been paid to microclusters, their types, roles and place in innovative processes; it has been proposed to use organizational, economic and administrative levers for their formation. The structure of the feasibility study (business plan) of the cluster project has been adduced. The necessity of developing the organizational and methodological base for the further implementation of cluster technologies has been noted

Management of high-tech production at a multilevel integrated enterprise using production flow standards (on the example of the aviation industry)

A virtual enterprise providing various stages of production of complex machine-building products by a network of interacting organizations is considered. The imperfection of the production management system within the framework of a virtual enterprise of this type is noted and it is proposed to improve it with the help of non-traditional application of production flow standards (PFS), extending this concept to the virtual enterprise as a whole. The composition of production flow standards, both traditional and non-traditional, which should be formed in the information systems of organizations, forming a virtual enterprise, is given. The procedure for the formation of production flow standards in these information systems and the procedure for their use for managing serial production management are considered. Recommendations on methods for calculating non-traditional production flow standards are formulated. The main projects that determine the practical implementation of proposals for the non-traditional application of production flow standards are indicated

Simulation of duplicate tooling consumption at aircraft manufacturing enterprises

To simulate the consumption of duplicate technological tooling (hereinafter referred to as TT), it is proposed to use the apparatus of multivariate regression analysis, which provides the main patterns formalization of consumption formation value in the form of linear regression dependencies. An important difference of the proposed approach to the development of regression models is an increased degree of detail due to the use of the number of detail operations performed using specific TT sizes as independent variables, which makes it possible to eliminate the calculation error associated with the presence of passing positions in the planning period (batches of parts and assembly units ). As a result, a quantitative assessment of the constructed dependencies based on the calculation of multiple correlation coefficients, the Fisher dispersion ratio, the Theil’s coefficient of irrelevance allowed us to conclude that they are adequate to the conditions of consumption TT at the aviation enterprise. To improve the adequacy of displaying real processes of TT consumption, the developed models are equipped with a parametric adaptation mechanism. The use of the steepest descent method makes it possible to adjust the regression parameters based on incoming data, taking into account the main trends in the development of the simulated process and providing for smoothing its random fluctuations

Formation of Consumption Properties of Sweet Pepper (Capsicum Annuum L.) Sauce

The aim of the study is to form consumption properties of a green sweet pepper sauce with a balanced content of macro- and microelements. Due to the use of Xanthium strumarium and chitosan a new product has high organoleptic properties that attract a consumer and increase its competitiveness at the market.Sweet green pepper that relates to most valuable vegetable cultures as to food value and taste was chosen as a main component of a sauce. For giving it a necessary consistence and for decreasing a time of thermal processing, there was used chitosan. According to results of the conducted studies, it was established, that among studied types of chitosan, advantages as to forming a consistence belongs to food acid-soluble chitosan with particle sizes up to 0,5 mm in amount 0,5 %.For preserving the natural green color, pepper fruits were preliminarily processed in 1 % decoction of Xanthium strumarium at temperature 75ºС during 15 min. For increasing its food value, the recipe was added with spicy-aromatic vegetable raw materials: garlic, dill, parsley, celery.The sauce quality was formed by mathematical modeling using general criteria of optimization of organoleptic parameters. There were also determined specific criteria of optimization of the recipe composition taking into account their daily need. As a result of the conducted studies the composition of recipe components for the sauce was optimized: sweet pepper 80 %, garlic leaves – 5 %, parsley leaves,dill – 5 %, celery leaves – 5 %, salt – 1,5 %, sugar – 0,5 %, chitosan – 0,5 %.There were studied organoleptic parameters of the developed sauce, characterized by a pleasant bright-green color, homogenous paste-like consistence, pleasant taste and smell. The used stabilizing factors allowed to get the sauce with the increased content of essential factors of nutrition. They participate in the increase of protective forces of the organism, so allow to recommend them in prophylactic, child and dietary nutrition

SELECTION OF PROJECTS FOR FINANCING ON THE BASIS COMPLEX OBJECT «PROJECT – ORGANIZATION» COMPETITIVENESS ASSESSMENT

The issues of system approach development to the selection process of projects proposed for financing and the construction of their rating score have been studied. This approach is a practical tool to justify the decision to support or reject projects. An interconnected system of functional tasks for assessing the competitiveness of a complex project-organization object and the direction of such an assessment have been proposed been proposed. The presented mathematics will allow take into account both various parameters of both the project itself and the features of the organization that plans to implement it. Such approach encourages these organizations, to increase their competitiveness. Based on the calculated ratings of complex objects there is their ranking. As a formalized means a matrix for the formation of decisions on the allocation of funds to the applicant organization to finance the declared project has been adduced

Two years of experience in hospital surveillance for the severe influenza like illnesses in St. Petersburg: etiology, clinical characterization of diseases, antigenic and genetic properties of isolated influenza viruses

In this paper, we analyze the etiology of the diseases occurring during two consecutive influenza epidemic seasons in St. Petersburg, Russian Federation. The analysis is based on the results of the PCR diagnostics of the clinical samples collected from patients hospitalized in three St. Petersburg hospitals with influenza like illnesses (ILI). It was shown that the influenza virus A(H1N1)pdm09 was the dominant causative agent during the 2012-2013 epidemic season while, in the 2013-2014 season, A(H3N2) virus was predominant among adults and children. The influenza B virus activity was high in the 2012-2013 season and low in the 2013-2014 season. During both seasons, the main causative agent for the hospitalization of young children was respiratory syncytial virus (RSV), followed by rhinovirus and influenza virus. The rate of involvement of parainfluenza, adenovirus, metapneumovirus and coronavirus was low and was negligible for bocavirus. Children 0-2 and 3-6 years old formed the group of patients that was affected by acute respiratory infection agents the most. Children younger than 3 months old were the major group of the intensive care unit (ICUs) patients and only 27.5% of them were adults. RSV and rhinovirus were the leading cause of ILI among the children admitted to ICU. Among the adult patients admitted to the ICU, only influenza A(H1N1)pdm09, A(H3N2) and B viruses were detected during both influenza seasons.According to the results of the antigenic and genetic analysis, most influenza A(H1N1)pdm09 and A(H3N2) viruses circulating in St. Petersburg matched the vaccine strains recommended by the WHO for vaccine composition in the 2012-2013 and 2013-2014 seasons.In this paper, we analyze the etiology of the diseases occurring during two consecutive influenza epidemic seasons in St. Petersburg, Russian Federation. The analysis is based on the results of the PCR diagnostics of the clinical samples collected from patients hospitalized in three St. Petersburg hospitals with influenza like illnesses (ILI). It was shown that the influenza virus A(H1N1)pdm09 was the dominant causative agent during the 2012-2013 epidemic season while, in the 2013-2014 season, A(H3N2) virus was predominant among adults and children. The influenza B virus activity was high in the 2012-2013 season and low in the 2013-2014 season. During both seasons, the main causative agent for the hospitalization of young children was respiratory syncytial virus (RSV), followed by rhinovirus and influenza virus. The rate of involvement of parainfluenza, adenovirus, metapneumovirus and coronavirus was low and was negligible for bocavirus. Children 0-2 and 3-6 years old formed the group of patients that was affected by acute respiratory infection agents the most. Children younger than 3 months old were the major group of the intensive care unit (ICUs) patients and only 27.5% of them were adults. RSV and rhinovirus were the leading cause of ILI among the children admitted to ICU. Among the adult patients admitted to the ICU, only influenza A(H1N1)pdm09, A(H3N2) and B viruses were detected during both influenza seasons. According to the results of the antigenic and genetic analysis, most influenza A(H1N1)pdm09 and A(H3N2) viruses circulating in St. Petersburg matched the vaccine strains recommended by the WHO for vaccine composition in the 2012-2013 and 2013-2014 seasons

Lipoprotein(a) concentration and the blood content of INFγ-producing T-helpers 17 (Th17/1) in males with premature coronary artery disease

Aim. To analyze the relationship of blood lipid profile parameters, including the level of lipoprotein(a) (Lp(a)), and the content of circulating CD4+ T-lymphocytes with premature coronary artery disease (CAD).Material and methods. This retrospective cross-sectional study included 76 men aged 40 to 79 years. Patients were divided into following groups: main group — patients with CAD (58 [54;64] years, n=56) onset before the age of 55; control group — patients (62 [57;66] years, n=20) without CAD and obstructive CAD and peripheral arterial disease. Statins were taken by 51 (91%) and 9 (45%) patients in the main and control groups, respectively. In serum and plasma samples, lipid spectrum parameters and Lp(a) concentration were determined. Cellular phenotyping was performed by direct immunofluorescence in a culture of mononuclear leukocytes isolated from blood. To determine cytokines, cells were in vitro activated with inhibitor of intracellular transport of secretory proteins. Cell fluorescence was determined using flow cytometry.Results. Patients of both groups were comparable in age, body mass index, prevalence of hypertension and diabetes. Blood Lp(a) concentrations were higher in the CAD group than in the control group (49 [10;102] mg/dL vs 12 [4,3;32] mg/ dL, p<0,05). The content of INFγ-producing T-helpers 17 (Th17/1) was also higher in the CAD group (19 [15;24] vs 13 [11;22], % of Th17, p=0,05). Logistic regression revealed that elevated Lp(a) levels (≥30 mg/dL) and relative amounts of Th17/1 (>14% of Th17) independently of each other, atherogenic lipoprotein cholesterol levels, classical risk factors, and statin use were associated with premature CAD in the general group of patients with odds ratio (OR) of 4,6 (95% confidence interval (CI), 1,1-20,2) and 10,9 (2,1-56,7), p<0,05, respectively. The combination of Lp(a) >30 mg/dl and Th17/1 over 14% significantly increased the risk of premature CAD (OR, 28,0, 95% CI, 4,31-181,75, p=0,0005).Conclusion. We have shown for the first time that an increased Lp(a) concentration with an increased Th17/1 content is associated with the premature CAD in men

Особенности этиологической структуры ОРВИ в отдельных возрастных и профессиональных группах населения Санкт-Петербурга в эпидемический сезон 2013-2014 гг .

The objective. To study etiological structure of acute respiratory viral diseases in the hospitalized patients of different age groups and to reveal their peculiarities in children and adults, as well as in adults of draft age (18–26 years) among civilians and military recruits.Materials and methods. 2202 in patients with acute respiratory diseases of moderate and severe degree, including 1123 patients (51.0%) aged up to 18 years and 1079 patients (49,0%) aged 18 years and above, were examined during the epidemic season since September 2013 till July 2014. RNA or DNA of influenza A(H1N1)pdm09 and A(H3N2), influenza B, types 1–4parainfluenza, adenoviruses, respiratory syncytial virus, rino-, metapneumo-, corona-, entero- and boca- viruses were determinedin nasopharyngeal swabs, sputum and brohchoalveolar lavage by real time PCR method. Significance of differences (p<0,05) in cases incidence of compared independent groups were assessed by the Pearson,s χ2 (chi-squared) test.Results. Genetic material of viruses causing ARD was revealed in 1343 cases (61,0%). Influenza viruses A and B (30,3%), RS viruses (23,6%), rinoviruses (22,8%) and adenoviruses (12,5%) prevail among ARD viral pathogens. The parainfluenza virus infection was laboratory confirmed in 8,7%, coronavirus – in 4,4%, bocavirus – in 1,2%, enterovirus – in 0,7% of cases. Assessment of age-related features of ARD etiologic structure showed that RS virus (37,6%, p<0,05) and parainfluenza virus (11,3%, p<0,05) infections were registered significantly often among children. Influenza viruses (46,4%, p<0,05), adenovirus (26,3%, p<0,05) and rinovirus (25,7%, p<0,05) were verified significantly often among adults. Etiologic ARD structure of military personnel 18–26 years old was characterized by significant prevalence of adenovirus infection (53,9%, p<0,05).Conclusion. The study has shown that acute respiratory diseases caused by RS and parainfluenza viruses predominated among children, by influenza viruses – among adults (civilians) and by adenovirus – among military personnel.Цель. Исследовать этиологическую структуру острых респираторных вирусных заболеваний у госпитализированных больных в разных возрастных и профессиональных группах и выявить ее особенности у детей и взрослых, а также у взрослых призывного возраста (18– 26 лет) из числа гражданских лиц и военнослужащих.Материалы и методы. В эпидемический сезон с сентября 2013 г. по июль 2014 г. обследовано 2202 стационарных больных острыми респираторными заболеваниями средней и тяжелой степенями тяжести, в том числе в возрасте до 18 лет – 1123 пациента (51,0%), 18 лет и старше – 1079 пациентов (49,0%). РНК или ДНК вирусов гриппа А(H1N1)pdm09 и А(H3N2), гриппа В, парагриппа 1–4 типов, аденовирусов, респираторно-синцитиального вируса, рино-, метапневмо-, корона-, бока- и энтеровирусов определяли в носоглоточных смывах, мокроте и бронхоальвеолярном лаваже методом ПЦР. Достоверность различия (p<0,05) частоты встречаемости случаев в сравниваемых независимых группах оценивали по критерию χ2 (хи-квадрат) Пирсена.Результаты. При обследовании больных генетический материал вирусов, вызывающих ОРЗ, выявлен в 1343 случаях (61,0%). Среди респираторных вирусов в качестве возбудителей ОРЗ доминируют вирусы гриппа А и В (30,3%), РС-вирусы (23,6%), риновирусы (22,8%) и аденовирусы (12,5%). Парагриппозная инфекция установлена в 8,7%, коронавирусная – в 4,4%, бокавирусная – в 1,2%, энтеровирусная – в 0,7% случаев. При оценке возрастных особенностей этиологической структуры ОРЗ выявлено, что среди детей достоверно чаще регистрировали РС-вирусную (37,6%, p<0,05) и парагриппозную (11,3%, p<0,05) инфекции. У взрослых достоверно чаще верифицировали грипп (46,4%, p<0,05), аденовирусную (26,3%, p<0,05) и риновирусную (25,7%, p<0,05) инфекции. Особенностью этиологической структуры ОРЗ у военнослужащих в возрасте 18–26 лет является достоверное преобладание аденовирусной инфекции (53,9%, p<0,05).Заключение. Исследование показало, что в структуре ОРЗ среди детей достоверно чаще регистрируют РС-вирусные заболевания и парагрипп, среди взрослых –грипп (у гражданских лиц) и аденовирусную инфекцию (у военнослужащих)