24 research outputs found

    International movement of open access to scientific knowledge: a quantitative analysis of country involvement

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    The study aims are to conduct a systematic quantitative analysis of Open Access (OA) Instruments and Initiatives, justify and develop the methodology for calculating the index of countries’ involvement in the Open Access movement. The authors identified all the significant OA-Instruments and OA-Initiatives, which were counted on the basis of the records in their OA-registers. Consolidation of records in these registers, according to literature data from the moment of their launch, made it possible to identify important patterns and features of the evolution of the OA-movemen

    ΠœΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌΡ‹ поврСТдСния эритроцитов ΠΏΡ€ΠΈ токсичСском дСйствии ΠΌΠ΅Ρ‚Π³Π΅ΠΌΠΎΠ³Π»ΠΎΠ±ΠΈΠ½ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»Π΅ΠΉ

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    Structural properties of lipid component of erythrocyte membrane of Wistar rats with methemoglobinemia were investigated after one injection of sodium nitrite and phenylhydrazin chloride in DL50 dose. It was shown that in methemoglobinemia cholesterol, lysophosphatidylcholine, sphingomyelin, phosphatidylserine levels are increased and phosphatidylcholine and phosphatidyletanolamine levels are decreased, and an increase of microviscousity of erythrocyte membrane lipid matrix was elevat-ed. The degree of the elucidated changes depends on a xenobiotic and a time of methemoglobinemia period.Π˜ΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ‹ структурныС свойства Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚Π° эритроцитарной ΠΌΠ΅ΠΌΠ±Ρ€Π°Π½Ρ‹ Ρƒ крыс Π»ΠΈΠ½ΠΈΠΈ Wistar ΠΏΡ€ΠΈ мСтгСмоглобинСмиях, ΠΈΠ½Π΄ΡƒΡ†ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… ΠΎΠ΄Π½ΠΎΠΊΡ€Π°Ρ‚Π½Ρ‹ΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ΠΌ Π½ΠΈΡ‚Ρ€ΠΈΡ‚Π° натрия ΠΈ солянокислого Ρ„Π΅Π½ΠΈΠ»Π³ΠΈΠ΄Ρ€Π°Π·ΠΈΠ½Π° Π² Π΄ΠΎΠ·Π°Ρ… DL50. Показано, Ρ‡Ρ‚ΠΎ ΠΏΡ€ΠΈ мСтгСмоглобинСмиях увСличиваСтся содСрТаниС холСстСрина, лизофосфатидилхолина, сфингомиСлина, фосфатидилсСрина, сниТаСтся ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ фосфатидилхолина ΠΈ фосфатидилэтаноламина, Π² ΠΌΠ΅ΠΌΠ±Ρ€Π°Π½Π΅ эритроцитов возрастаСт ΠΌΠΈΠΊΡ€ΠΎΠ²ΡΠ·ΠΊΠΎΡΡ‚ΡŒ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ матрикса. Π‘Ρ‚Π΅ΠΏΠ΅Π½ΡŒ выявлСнных ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ зависит ΠΎΡ‚ Π²ΠΈΠ΄Π° ксСнобиотика ΠΈ ΠΏΡ€ΠΎΠ΄ΠΎΠ»ΠΆΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Π° ΠΌΠ΅Ρ‚Π³Π΅ΠΌΠΎΠ³Π»ΠΎΠ±ΠΈΠ½Π΅ΠΌΠΈΠΈ

    ΠœΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌΡ‹ рСгуляции объСма эритроцитов Ρƒ кардиохирургичСских Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с ΡƒΠΌΠ΅Ρ€Π΅Π½Π½Ρ‹ΠΌ ΠΈ Π²Ρ‹Ρ€Π°ΠΆΠ΅Π½Π½Ρ‹ΠΌ Π³Π΅ΠΌΠΎΠ»ΠΈΠ·ΠΎΠΌ послС ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΉ Π½Π° остановлСнном сСрдцС

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    A study of mechanisms of regulation of volume of erythrocytes in cardiosurgical patients with moderate (24 patients) and expressed (13 patients) hemolysis after coronary artery bypass grafting in conditions of cardiopulmonary bypass was carried out. It was established that development expressed hemolysis is associated with higher (than under moderate hemolysis) volume of erythrocytes after operation, reduction Π‘Π°2+-dependent К+-permeability and activity of NΠ°+/K+-ATPazy in their against deficiency of ATP in cells. At patients with moderated hemolysis independently of an investigation phase Π‘Π°2+-dependent К+-permeability of a membrane of erythrocytes doesn't differ from healthy donors, but activity of NΠ°+/K+-ATPazy is reduced at the sufficient content of ATP.ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΎ исслСдованиС ΠΌΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌΠΎΠ² рСгуляции объСма эритроцитов Ρƒ кардиохирургичСских Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с ΡƒΠΌΠ΅Ρ€Π΅Π½Π½Ρ‹ΠΌ (24 Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°) ΠΈ Π²Ρ‹Ρ€Π°ΠΆΠ΅Π½Π½Ρ‹ΠΌ (13 Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊ) Π³Π΅ΠΌΠΎΠ»ΠΈΠ·ΠΎΠΌ послС ΠΊΠΎΡ€ΠΎΠ½Π°Ρ€Π½ΠΎΠ³ΠΎ ΡˆΡƒΠ½Ρ‚ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΡ Π² условиях искусствСнного кровообращСния. УстановлСно, Ρ‡Ρ‚ΠΎ Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ Π²Ρ‹Ρ€Π°ΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ Π³Π΅ΠΌΠΎΠ»ΠΈΠ·Π° ассоциировано с бóльшим, Ρ‡Π΅ΠΌ ΠΏΡ€ΠΈ ΡƒΠΌΠ΅Ρ€Π΅Π½Π½ΠΎΠΌ Π³Π΅ΠΌΠΎΠ»ΠΈΠ·Π΅, объСмом эритроцитов послС ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΈ, ΡƒΠΌΠ΅Π½ΡŒΡˆΠ΅Π½ΠΈΠ΅ΠΌ ΠΈΡ… Π‘Π°2+-зависимой К+-проницаСмости ΠΈ активности NΠ°+/K+-ATΠ€Π°Π·Ρ‹ Π½Π° Ρ„ΠΎΠ½Π΅ Π΄Π΅Ρ„ΠΈΡ†ΠΈΡ‚Π° АВЀ Π² ΠΊΠ»Π΅Ρ‚ΠΊΠ°Ρ…. Π£ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с ΡƒΠΌΠ΅Ρ€Π΅Π½Π½Ρ‹ΠΌ Π³Π΅ΠΌΠΎΠ»ΠΈΠ·ΠΎΠΌ Π²Π½Π΅ зависимости ΠΎΡ‚ этапа исслСдования Π‘Π°2+-зависимая К+-ΠΏΡ€ΠΎΠ½ΠΈΡ†Π°Π΅ΠΌΠΎΡΡ‚ΡŒ ΠΌΠ΅ΠΌΠ±Ρ€Π°Π½Ρ‹ эритроцитов Π½Π΅ отличаСтся ΠΎΡ‚ Ρ‚Π°ΠΊΠΎΠ²ΠΎΠΉ Ρƒ Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹Ρ… Π΄ΠΎΠ½ΠΎΡ€ΠΎΠ², Π½ΠΎ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ NΠ°+/K+-ATΠ€Π°Π·Ρ‹ сниТСна ΠΏΡ€ΠΈ достаточном содСрТании АВЀ

    Mechanisms of regulation of erythrocytes volume in cardiosurgical patients with moderated and expressed the hemolysis after operations

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    A study of mechanisms of regulation of volume of erythrocytes in cardiosurgical patients with moderate (24 patients) and expressed (13 patients) hemolysis after coronary artery bypass grafting in conditions of cardiopulmonary bypass was carried out. It was established that development expressed hemolysis is associated with higher (than under moderate hemolysis) volume of erythrocytes after operation, reduction Ба2+-dependent К+-permeability and activity of Nа+/K+-ATPazy in their against deficiency of ATP in cells. At patients with moderated hemolysis independently of an investigation phase Ба2+-dependent К+-permeability of a membrane of erythrocytes doesn't differ from healthy donors, but activity of Nа+/K+-ATPazy is reduced at the sufficient content of ATP

    The new test object for evaluating the quality of disinfected water

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    ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΌΠΎΠ½Ρ–Ρ‚ΠΎΡ€ΠΈΠ½Π³ Π΄ΠΆΠ΅Ρ€Π΅Π» водопостачання Ρ‚Π° Π²ΠΎΠ΄ΠΎΠΏΡ€ΠΎΠ²Ρ–Π΄Π½ΠΎΡ— Π²ΠΎΠ΄ΠΈ ΠΌ. ΠšΠΈΡ”Π²Π°. ВстановлСно, Ρ‰ΠΎ Π³Ρ€ΠΈΠ±ΠΈ Ρ€ΠΎΠ΄Ρƒ Candida Π·ΡƒΡΡ‚Ρ€Ρ–Ρ‡Π°ΡŽΡ‚ΡŒΡΡ повсюдно. Показано, Ρ‰ΠΎ Ρ†Ρ– мікроскопічні Π³Ρ€ΠΈΠ±ΠΈ Π±Ρ–Π»ΡŒΡˆ стійкі Π΄ΠΎ Π΄Ρ–Ρ— Ρ€Ρ–Π·Π½ΠΈΡ… Π΄Π΅Π·Ρ–Π½Ρ„Π΅ΠΊΡ‚Π°Π½Ρ‚Ρ–Π² Ρƒ порівнянні Π· санітарно-ΠΏΠΎΠΊΠ°Π·ΠΎΠ²ΠΈΠΌ ΠΌΡ–ΠΊΡ€ΠΎΠΎΡ€Π³Π°Π½Ρ–Π·ΠΌΠΎΠΌ Escherichia coli. Π—Π°ΠΏΡ€ΠΎΠΏΠΎΠ½ΠΎΠ²Π°Π½ΠΎ Π½ΠΎΠ²ΠΈΠΉ тСст-об’єкт для ΠΎΡ†Ρ–Π½ΠΊΠΈ якості Π·Π½Π΅Π·Π°Ρ€Π°ΠΆΠ΅Π½ΠΎΡ— Π²ΠΎΠ΄ΠΈ.Monitoring of water sources and tap water in Kiev was conducted. It was found that the fungi of Candida genus are ubiquitous. It is shown that these microscopic fungi are more resistant to various disinfectants compared to sanitary indicative microorganism Escherichia coli. A new test object for evaluating the quality of purified water is proposed.ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½ ΠΌΠΎΠ½ΠΈΡ‚ΠΎΡ€ΠΈΠ½Π³ источников водоснабТСния ΠΈ Π²ΠΎΠ΄ΠΎΠΏΡ€ΠΎΠ²ΠΎΠ΄Π½ΠΎΠΉ Π²ΠΎΠ΄Ρ‹ Π³. КиСва. УстановлСно, Ρ‡Ρ‚ΠΎ Π³Ρ€ΠΈΠ±Ρ‹ Ρ€ΠΎΠ΄Π° Candida Π²ΡΡ‚Ρ€Π΅Ρ‡Π°ΡŽΡ‚ΡΡ повсСмСстно. Показано, Ρ‡Ρ‚ΠΎ эти микроскопичСскиС Π³Ρ€ΠΈΠ±Ρ‹ Π±ΠΎΠ»Π΅Π΅ устойчивы ΠΊ Π΄Π΅ΠΉΡΡ‚Π²ΠΈΡŽ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… Π΄Π΅Π·ΠΈΠ½Ρ„Π΅ΠΊΡ‚Π°Π½Ρ‚ΠΎΠ² Π² сравнСнии с санитарно-ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹ΠΌ ΠΌΠΈΠΊΡ€ΠΎΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠΎΠΌ Escherichia coli. ΠŸΡ€Π΅Π΄Π»ΠΎΠΆΠ΅Π½ Π½ΠΎΠ²Ρ‹ΠΉ тСст-ΠΎΠ±ΡŠΠ΅ΠΊΡ‚ для ΠΎΡ†Π΅Π½ΠΊΠΈ качСства ΠΎΠ±Π΅Π·Π·Π°Ρ€Π°ΠΆΠ΅Π½Π½ΠΎΠΉ Π²ΠΎΠ΄Ρ‹
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