14 research outputs found
Low-lying octupole isovector excitation in Nd-144
International audienceThe nature of low-lying 3â levels in Nd144 was investigated in the Nd143(n,γγ) cold neutron-capture reaction. The combination of the high neutron flux from the research reactor at the Institut Laue-Langevin and the high Îł-ray detection efficiency of the EXILL setup allowed the recording of γγ coincidences. From the coincidence data precise branching ratios were extracted. Furthermore, the octagonal symmetry of the setup allowed angular-distribution measurements to determine multipole-mixing ratios. Additionally, in a second measurement the ultra-high resolution spectrometer GAMS6 was employed to conduct lifetime measurements using the gamma-ray induced Doppler-shift technique (GRID). The confirmed strong M1 component in the 33ââ31â decay strongly supports the assignment of the 33â level at 2779keV as low-lying isovector octupole excitation. Microscopic calculations within the quasiparticle phonon model confirm an isovector component in the wave function of the 33â level, firmly establishing this fundamental mode of nuclear excitation in near-spherical nuclei
Clinical Outcomes of Two-Stage Implantation in Reverse Shoulder Arthroplasty for Postinfectious End-Stage Glenohumeral Arthritis in Native Shoulders: A Single-Center Cohort Study with a Minimum 2-Year Follow-up
Background: Septic arthritis of the shoulder is a rare but devastating condition that may lead to joint destruction. There are few studies and limited outcome data on shoulder arthroplasty for infected native shoulders with end-stage glenohumeral arthritis (GHA). Hence, this study aimed to demonstrate the clinical outcomes of two-stage implantation in reverse shoulder arthroplasty (RSA) using an antibiotic spacer in the first stage for this challenging condition. Methods: We conducted a retrospective study on two-stage implantation in RSA in infected shoulders. Patients were diagnosed with end-stage GHA due to primary shoulder sepsis or infection following non-arthroplasty shoulder surgery. Laboratory data, range of motion (ROM), and functional scores including American Shoulder and Elbow Surgeons score, Constant score, and Disabilities of the Arm, Shoulder and Hand score were assessed prior to spacer placement and at the latest follow-up. Furthermore, intraoperative and postoperative complications were recorded. Results: In this study, 10 patients with a mean age of 54.8 ± 15.8 years (range, 30â77 years) were included. The mean follow-up period was 37.3 ± 9.1 months (range, 25â56 months). All postoperative ROM measurements and functional scores were improved significantly. Although no reinfection was observed, a total of 5 complications including 2 hematomas, 1 intraoperative humeral fracture, 1 humeral stem loosening, and 1 anterior deltoid dysfunction were observed in 4 patients after a follow-up period of at least 2 years after RSA. Conclusions: Two-stage implantation in RSA is an effective method for improving the function and controlling the infection in postinfectious end-stage GHA in native shoulders
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Phage Wrapping with Cationic Polymers Eliminates Nonspecific Binding between M13 Phage and High p/Target Proteins
M13 phage have provided scaffolds for nanostructure synthesis based upon self-assembled inorganic and hard materials interacting with phage-displayed peptides. Additionally, phage display has been used to identify binders to plastic, TiO(2), and other surfaces. However, synthesis of phage-based materials through the hybridization of soft materials with the phage surface remains unexplored. Here, we present an efficient âphage wrappingâ strategy for the facile synthesis of phage coated with soluble, cationic polymers. Polymers bearing high positive charge densities demonstrated the most effective phage wrapping, as shown by assays for blocking non-specific binding of the anionic phage coat to a high pI target protein. The results establish the functional group requirements for hybridizing phage with soft materials, and solve a major problem in phage display â non-specific binding by the phage to high pI target proteins
Identification of low-energy isovector octupole states in Nd
International audienceRecently, first candidates for low-lying isovector states in the octupole sector were suggested. The unambiguous identification of those states will contribute to the decomposition of the octupole-octupole residual interaction in an isoscalar and isovector part. This will help us understand the octupole degree of freedom. In 144Nd the 3â state at 2778 keV is a good candidate for such a "mixed-symmetry'' octupole state. In order to clarify the nature of this state, a 143Nd(n, Îł)-experiment was conducted with the EXILL-setup. Following neutron capture the 3â states are populated and EXILL provides the opportunity to determine the multipole-mixing ratios of the 3i ââ31 - transitions. For the transition from the "mixed-symmetry" octupole state to the symmetric 31 â state we expect a strong M1 component
Identification of low-energy isovector octupole states in 144
Recently, first candidates for low-lying isovector states in the octupole sector were suggested. The unambiguous identification of those states will contribute to the decomposition of the octupole-octupole residual interaction in an isoscalar and isovector part. This will help us understand the octupole degree of freedom. In 144Nd the 3â state at 2778 keV is a good candidate for such a "mixed-symmetry'' octupole state. In order to clarify the nature of this state, a 143Nd(n, Îł)-experiment was conducted with the EXILL-setup. Following neutron capture the 3â states are populated and EXILL provides the opportunity to determine the multipole-mixing ratios of the 3i ââ31 - transitions. For the transition from the "mixed-symmetry" octupole state to the symmetric 31 â state we expect a strong M1 component
Substrate-Initiated Synthesis of Cell-Penetrating Poly(disulfide)s
Lessons from surface-initiated polymerization are applied to grow cell-penetrating poly(disulfide)s directly on substrates of free choice. Reductive depolymerization after cellular uptake should then release the native substrates and minimize toxicity. In the presence of thiolated substrates, propagators containing a strained disulfide from asparagusic or, preferably, lipoic acid and a guanidinium cation polymerize into poly(disulfide)s in less than 5 min at room temperature at pH 7. Substrate-initiated polymerization of cationic poly(disulfide)s and their depolymerization with dithiothreitol causes the appearance and disappearance of transport activity in fluorogenic vesicles. The same process is further characterized by gel-permeation chromatography and fluorescence resonance energy transfer