Early influences on cardiovascular and renal development

The hypothesis that a developmental component plays a role in subsequent disease initially arose from epidemiological studies relating birth size to both risk factors for cardiovascular disease and actual cardiovascular disease prevalence in later life. The findings that small size at birth is associated with an increased risk of cardiovascular disease have led to concerns about the effect size and the causality of the associations. However, recent studies have overcome most methodological flaws and suggested small effect sizes for these associations for the individual, but an potential important effect size on a population level. Various mechanisms underlying these associations have been hypothesized, including fetal undernutrition, genetic susceptibility and postnatal accelerated growth. The specific adverse exposures in fetal and early postnatal life leading to cardiovascular disease in adult life are not yet fully understood. Current studies suggest that both environmental and genetic factors in various periods of life may underlie the complex associations of fetal growth retardation and low birth weight with cardiovascular disease in later life. To estimate the population effect size and to identify the underlying mechanisms, well-designed epidemiological studies are needed. This review is focused on specific adverse fetal exposures, cardiovascular adaptations and perspectives for new studies. Copyrigh

The Rotterdam Study: 2012 objectives and design update

The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, oncological, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. The findings of the Rotterdam Study have been presented in over a 1,000 research articles and reports (see www.erasmus-epidemiology.nl/rotterdamstudy). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods

Ancient civilizations already had an impact on cladoceran assemblages in Europe's oldest lake

Lake Ohrid (Republic of North Macedonia) is the oldest and most biodiverse freshwater lake in Europe. While the lake has recently been under severe anthropogenic pressure, historical impacts are poorly studied. We used paleolimnological information, particularly from cladoceran assemblages, to describe the long-term anthropogenic impacts that the lake has experienced over the last 6650 years. Multivariate analyses of cladoceran abundances together with selected environmental indicators were used to distinguish natural from human impacts and to track the direction and causes of observed changes. In addition, morphological analyses of planktonic Bosmina allowed us to assess the effects of fisheries and aquaculture on cladoceran phenotypic plasticity. Our findings reveal that the lake has been regularly exposed to anthropogenic impacts during the last millennia, including habitat deterioration, shifts in the food web and species introductions. Before 2400 cal yr BP, cladocerans showed the highest diversity values, and the relatively larger size of Bosmina longirostris indicated limited zooplanktivory. Since 2400 cal yr BP, coinciding with the foundation of the town of Ohrid and elevated erosion and deforestation, there has been a progressive loss of littoral taxa. Since 1700 cal yr BP, fish introductions have increased, inducing morphological changes in Bosmina, which resulted in a significant decrease in body size and antennule length and an increase in mucro and antennule angle. We also show that the present-day cladoceran community differs from the prehistoric community due to the invasion of Diaphanosoma. Overall, our results highlight the sensitivity of this unique ecosystem to human alterations, which began before the Anthropocene

Supplementary Material for: Increased Levels of Copeptin, a Surrogate Marker of Arginine Vasopressin, Are Associated with an Increased Risk of Chronic Kidney Disease in a General Population

<i>Background:</i> Our aim was to test if plasma copeptin, a stable surrogate marker of arginine vasopressin, predicts decline of glomerular filtration rate (GFR) and risk of chronic kidney disease (CKD). <i>Methods:</i> We measured copeptin and renal function at the Malmö Diet and Cancer Cardiovascular Cohort baseline exam and reassessed renal function after a follow-up time of 16.6 ± 1.5 years (n = 3,186). Furthermore, we defined CKD based on an estimated GFR (eGFR) calculated by the Modification of Diet in Renal Disease (MDRD) <60 (CKD_60MDRD), <45 (CKD_45MDRD) and <30 (CKD_30MDRD) ml/min/1.73 m2. <i>Results:</i> After multivariate adjustment (gender, age, baseline eGFR, smoking status, systolic blood pressure, antihypertensive treatment and follow-up time), copeptin (beta-coefficient per 1 SD increment of copeptin) was independently associated with significantly greater annual decline of eGFR (ml/min/1.73 m2) according to the MDRD formula (OR 0.057, 95% CI 0.022-0.093; p = 0.001) as well as according to the CKD Epidemiology Collaboration (CKD-EPI) formula (OR 0.050, 95% CI 0.022-0.077; p < 0.001). Each SD increment of copeptin independently predicted incident CKD_60MDRD (OR 1.19, 95% CI 1.04-1.36; p = 0.010), CKD_45MDRD (OR 1.33, 95% CI 1.04-1.71; p = 0.026) and CKD_30MDRD (OR 3.69, 95% CI 1.41-9.66; p = 0.008). The relationship between copeptin and CKD defined by CKD-EPI gave similar results. <i>Conclusion:</i> Our data suggest that increased levels of copeptin independently predict decline in eGFR and greater risk of new-onset CKD

Circadian acclimatization of performance, sleep, and 6-sulfatoxymelatonin using multiple phase shifting stimuli

Misalignment between the environment and one’s circadian system is a common phenomenon (e.g., jet lag) which can have myriad negative effects on physical and mental health, mental and physiological performance, and sleep. Absent any intervention, the circadian system adjusts only 0.5-1.0 h per day to a shifted light-dark and sleep-wake schedule. Bright light facilitates circadian adjustment, but in field studies, bright light is only modestly better than no stimulus. Evidence indicates that exercise and melatonin can be combined with bright light to elicit larger shifts but no study has combined all of these stimuli or administered them at the times that are known to elicit the largest effects on the circadian system. The aims of this study are to compare the effects of different treatments on circadian adjustment to simulated jet lag in a laboratory. Following 2 weeks of home recording, 36 adults will spend 6.5 consecutive days in the laboratory. Following an 8 h period of baseline sleep recording on the participant’s usual sleep schedule on Night 1 (e.g., 0000-0800 h), participants will undergo a 26 h circadian assessment protocol involving 2 h wake intervals in dim light and 1 h of sleep in darkness, repeated throughout the 26 h. During this protocol, all urine voidings will be collected; mood, sleepiness, psychomotor vigilance, and pain sensitivity will be assessed every 3 h, forehead temperature will be assessed every 90 min, and anaerobic performance (Wingate test) will be tested every 6 h. Following, the circadian assessment protocol, the participant’s sleep-wake and light dark schedule will be delayed by 8 h compared with baseline (e.g., 0800-1400 h), analogous to travelling 8 times zones westward. This shifted schedule will be maintained for 3 days. During the 3 days on the delayed schedule, participants will be randomized to one of 3 treatments: (1) Dim Red Light + Placebo Capsules, (2) Bright Light Alone, (3) Bright Light + Exercise + Melatonin. During the final 26 h, all conditions and measures of the baseline circadian protocol will be repeated. Acclimatization will be defined by shifts in circadian rhythms of aMT6s, psychomotor vigilance, Wingate Anaerobic performance, mood, and sleepiness, and less impairments in these measures during the shifted schedule compared with baseline. We posit that Bright Light Alone and Bright Light + Exercise + Melatonin will elicit greater shifts in circadian rhythms and less impairments in sleep, mood, performance, and sleepiness compared with Dim Red Light + Placebo Capsules. We also posit that Bright Light + Exercise + Melatonin will elicit greater shifts and less impairments than Bright Light Alone. Copyright © 2022 Youngstedt, Elliott, Patel, Zi-Ching Mak, Raiewski, Malek, Strong, Mun, Peters, Madlol, Tasevska, Rasoul, Nguyen, Vargas Negrete, Adaralegbe, Sudalaimuthu, Granholm, Finch, Eksambe, Malready and Parthasarathy.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Assessment of status and evolution of ecosystem service indicators

Ecosystem services indicators are important to measure the trends and state of ecosystem service delivery; with recent years seeing a wide indicator base being developed. Indicators are powerful tools to inform and improve the knowledge base on ecosystems and ecosystem services, which are useful for decision makers at any spatial scale for basing their decisions on evidence and also at a higher levels. A selection of Protected Areas (PAs) from mountain, coast and marine, and arid ecosystems were used as case study areas to investigate a selection of ecosystem indicators and how they can be used to monitor ecosystem services in PAs. In total twelve PAs participated in this report, five from mountain areas, two from arid/semi-arid areas and five from coastal/marine areas. The types of ecosystem service are concurrent with the CICES classification, but the selection of most relevant ecosystem service varies between different PAs. Where possibly, supply, demand and beneficiaries were defined for each of the ecosystem service