Effects of agmatine sulphate on facial nerve injuries

PubMedID: 28122652Objective: To evaluate the effect of agmatine sulphate on facial nerve regeneration after facial nerve injury using electron and light microscopy. Methods: The study was performed on 30 male Wistar albino rats split into: a control group, a sham-treated group, a study control group, an anastomosis group, and an anastomosis plus agmatine sulphate treatment group. The mandibular branch of the facial nerve was dissected, and a piece was removed for histological and electron microscopic examination. Results: Regeneration was better in the anastomosis group than in the study control group. However, the best regeneration findings were seen in the agmatine sulphate treatment group. There was a significant difference between the agmatine group and the others in terms of median axon numbers (p < 0.004) and diameters (p < 0.004). Conclusion: Agmatine sulphate treatment with anastomosis in traumatic facial paralysis may enhance nerve regeneration. Copyright © JLO (1984) Limited 2017

Electron microscopic imaging of osteonecrosis in chronic supurative otitis media

Objective: In this study, we aimed to demonstrate electron microscopiccellular changes of bone necrosis developing due to chronic otitis media. Material and Methods: This study was performed on the pathologic tissue samples of 20 cases that were operated due to chronic supurative otitis media in Çukurova University Ear Nose Throat Department. Collected cholesteatoma tissue samples, granulation tissue samples, incus and mastoid bone samples were examined by JEOL-JEM 1400 transmission electron microscopy after dyeing. Results: Incus and mastoid bone were examined together in 16 of the operated patients. In the remaining 4 patients, only mastoid bones were examined as the ossicles were absent. Fourteen patients showed cholesteatoma in the middle ear and/or mastoid cellulae, and 6 patients showed granulation tissue. Middle ear ossicles were corroded in 13 of 14 (92.8%) patients with chronic otitis media and cholesteatoma versus 3 of 6 (50%) patients with chronic otitis media without cholesteatoma. In the samples of patients with chronic otitis media and cholesteatoma, ossicles were irregular, besides increase in vascularity; dense cellular infiltration was also observed. Swollen endoplasmic reticulum and cytoplasmic vacuoles are among the findings that support the enzymatic theory. Examination of incus samples revealed degenerative changes and large vacuoles in cells. Conclusion: This study was not able to demonstrate enzymatic theory, it may shed light on further studies focusing on osteonecrosis. © 2005 The Mediterranean Society of Otology and Audiology

Endoscopic versus microscopic stapes surgery

PubMedID: 27461175Objective The aim of this study to compare the outcomes and complications of endoscopic stapes surgery versus microscopic stapes surgery. Methods This study involved patients who underwent stapedotomy at the Department of Otorhinolaryngology, Faculty of Medicine, Cukurova University between January 2012 and July 2014. The patients were divided into two groups. Patients in group I were operated with endoscope and patients in group II were operated with microscope. Pure tone audiometry was carried out in all patients preoperatively. Peroperative surgical findings, complications, and duration of surgery were noted and compared between the two groups. Air conduction and bone conduction thresholds were measured at frequencies of 500, 1000, 2000, and 4000 Hz, and the mean (±SD) air-bone gap was noted. Results Mean preoperative air-bone gap was 36.9 ± 6.8 dB (23.3–50 dB) in group I and 35.1 ± 6 dB (26.6–50 dB) in group II. Mean postoperative air-bone gap was 9.3 ± 7.1 dB (0–30 dB) in group I and 13.5 ± 9.7 dB (1.6–35 dB) in group II. The difference in preoperative and postoperative air-bone gap between the two groups was statistically significant (p = 0.023). Patients in group I did not complain of postoperative pain but this was felt in four patients in group II. The difference was statistically significant (p = 0.045). Conclusion Endoscopic stapes surgery has many benefits such as good visualization, and easy accessibility to the stapes, oval window niche, and facial nerve. Removal of the scutum and manipulation of the chorda tympani nerve are less frequent with the endoscopic technique. © 2016 Elsevier Ireland Lt

Effect of Intraoperative Neuromonitorization on Voice Quality During Total Thyroidectomy

International Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland -- 2017 -- Glasgow, SCOTLANDWOS: 000406476100045…Assoc Surg Great Britain & Irelan

How does cochlear implantation affect five vestibular end-organ functions and dizziness?

PubMedID: 30100248Objective: To evaluate all five vestibular end-organ functions (lateral, anterior, posterior semicircular canal, utricule, and saccule) and to investigate the relationship between Dizziness Handicap Inventory (DHI) and vestibular functions prior to CI (cochlear implantation) and at postoperative day 3 and month 3. Methods: A total of 42 patients (age 16–70 years) with normal vestibular functions preoperatively and undergoing unilateral CI were included in this prospective descriptive study. Video head impulse test (vHIT) for three semicircular canal (SSC) functions, ocular vestibular-evoked myogenic potential (oVEMP) for utricule function, cervical vestibular-evoked myogenic potential (cVEMP) for saccule function and DHI for subjective vertigo symptoms were performed prior to CI and at postoperative day 3 and month 3. Results: There was a significant impairment of vestibular function in 12 patients (28.5%) on the implantation side and significant DHI increase was observed in 13 of 42 (30.9%) patients at postoperative day 3 after CI (p 0.05). The deterioration in cVEMP continued in 5 (11.9%) patients (p 0.05). There was a significant correlation between DHI and objective vestibular tests both in the early and late postoperative period (r = 0.795; p < 0.05). Conclusion: Our study showed that both canal and otolith functions can be damaged after CI especially in the early postoperative period. Surprisingly, posterior SSC functions were more affected than lateral SSC. Therefore, a gold standard vestibular test battery that can evaluate each of three SSC canals and two otoliths functions is essential. Since a single vestibular test for this purpose is not available, we recommend the use of the three available vestibular tests together. This test battery, which is capable of evaluating five vestibular end-organ functions in preoperative and postoperative vestibular evaluations, can provide more accurate results not only for CI but also for most otologic surgeries. © 2018 Elsevier B.V.This study was not supported by any organization or foundation

The effect of zoledronic acid on middle ear osteoporosis: An animal study

PubMedID: 30481855Hearing function in older patients may be related to bone structure. We conducted an experiment to evaluate the effect of zoledronic acid on osteoporotic middle ear ossicles in an animal model. Our subjects were 19 female New Zealand white rabbits (38 ears) weighing 2 to 4 kg. We divided the rabbits into three groups: One group consisted of 6 rabbits with osteoporotic ears that were treated with zoledronic acid; the second group was made up of 8 rabbits with osteoporotic ears that were not treated; a control group included 5 rabbits with normal ears that were untreated. After an oophorectomy, the 6 study rabbits were administered 0.1 ml/kg of zoledronic acid intravenously. All rabbits were sacrificed 16 weeks later, and the middle ear ossicles were removed for investigation under light microscopy. Although osteoporosis enhanced the osteoclastic bone resorption of the ossicles, zoledronic acid enhanced osteoblastic activity on osteoporotic middle ear ossicles. The incidence of osteoporosis was 93.8% in the untreated osteoporosis group and 33.3% in zoledronic acid group-a statistically significant difference (OR: 0.24; 95% CI: 0.09 to 0.58; p < 0.001). Osteoporosis appears to increase the resorption of the middle ear ossicles, a process that can be avoided with zoledronic acid administration. Prevention of the effects of osteoporosis in humans may help decrease the irreversible changes in the middle ear ossicles. © 2018 Medquest Communications LLC. All rights reserved

Investigation the expression of hypoxia inducible factors and embryonic stem cell genes in patients with laryngeal carcinoma

52nd Conference of the European-Society-of-Human-Genetics (ESHG) -- JUN 15-18, 2019 -- Gothenburg, SWEDENWOS: 000489313904134…European Soc Human Gene

Transcutaneous bone-anchored hearing aids versus percutaneous ones: Multicenter comparative clinical study

PubMedID: 25730451The aim of this study is to compare the clinical audiological outcomes as well as patient satisfaction of boneanchored, hearing aid surgery between the percutaneous Dermalock and the transcutaneous Attract systems. Study Design and Methods: This is a multicenter, retrospective clinical study. The patients who underwent Baha Dermalock and Baha Attract surgery were analyzed for hearing results, surgical complications, and postoperative follow-up specifications for both systems. Speech reception thresholds and bone conduction thresholds with and without aided conditions were evaluated. Patient satisfactions were also determined for both groups by Glasgow Benefit Inventory questionnaire. Results: Both of the groups had some minor complications such as skin irritations around the abutment and skin erythema over the magnet. Both of the groups benefit from the devices audiologically; however, when the groups were compared, better results were observed in the percutaneous, boneconduction group. Conclusion: We can confirm that both transcutaneous and percutaneous techniques are effective in the rehabilitation of conductive hearing loss when conventional hearing aids cannot be used. However, both of the systems have some advantages and limitations in terms of audiological and surgical perspectives. © 2015 Otology and Neurotology, Inc