Gastro-Esophageal Reflux in Children

Gastro-esophageal reflux (GER) is common in infants and children and has a varied clinical presentation: from infants with innocent regurgitation to infants and children with severe esophageal and extra-esophageal complications that define pathological gastro-esophageal reflux disease (GERD). Although the pathophysiology is similar to that of adults, symptoms of GERD in infants and children are often distinct from classic ones such as heartburn. The passage of gastric contents into the esophagus is a normal phenomenon occurring many times a day both in adults and children, but, in infants, several factors contribute to exacerbate this phenomenon, including a liquid milk-based diet, recumbent position and both structural and functional immaturity of the gastro-esophageal junction. This article focuses on the presentation, diagnosis and treatment of GERD that occurs in infants and children, based on available and current guidelines

Nature of the constant factor in the relation between radial breathing mode frequency and tube diameter for single-wall carbon nanotubes

Resonance Raman scattering is used to determine the radial breathing mode (RBM) frequency (ωRBM) dependence on tube diameter (dt) for single-wall carbon nanotubes (SWNTs). We establish experimentally the ωRBM=227.0/dt as the fundamental relation for pristine SWNTs. All the other RBM values found in the literature can be explained by an upshift in frequency due mostly to van der Waals interaction between SWNTs and environment

Bayesian Accretion Modeling: Axisymmetric Equatorial Emission in the Kerr Spacetime

The Event Horizon Telescope (EHT) has produced images of two supermassive black holes, Messier~87* (M 87*) and Sagittarius~A* (Sgr A*). The EHT collaboration used these images to indirectly constrain black hole parameters by calibrating measurements of the sky-plane emission morphology to images of general relativistic magnetohydrodynamic (GRMHD) simulations. Here, we develop a model for directly constraining the black hole mass, spin, and inclination through signatures of lensing, redshift, and frame dragging, while simultaneously marginalizing over the unknown accretion and emission properties. By assuming optically thin, axisymmetric, equatorial emission near the black hole, our model gains orders of magnitude in speed over similar approaches that require radiative transfer. Using 2017 EHT M 87* baseline coverage, we use fits of the model to itself to show that the data are insufficient to demonstrate existence of the photon ring. We then survey time-averaged GRMHD simulations fitting EHT-like data, and find that our model is best-suited to fitting magnetically arrested disks, which are the favored class of simulations for both M 87* and Sgr A*. For these simulations, the best-fit model parameters are within ${\sim}10\%$ of the true mass and within ${\sim}10^\circ$ for inclination. With 2017 EHT coverage and 1\% fractional uncertainty on amplitudes, spin is unconstrained. Accurate inference of spin axis position angle depends strongly on spin and electron temperature. Our results show the promise of directly constraining black hole spacetimes with interferometric data, but they also show that nearly identical images permit large differences in black hole properties, highlighting degeneracies between the plasma properties, spacetime, and most crucially, the unknown emission geometry when studying lensed accretion flow images at a single frequency.Comment: Accepted to ApJ, 16 pages, 10 figure

Position-dependent mass systems: Classical and quantum pictures

Extended abstract of "Algebraic approach to position-dependent mass systems in both classical and quantum pictures", a series of three lectures delivered by the author in the VIII School on Geometry and Physics, 24 June-8 June 2019, organized by the Department of Mathematical Physics of the University of Bialystok, in Bialowieza, Poland (http://wgmp.uwb.edu.pl/wgmp38/part_s.html)Comment: 12 pages, no figure

The EUSO simulation and analysis framework

ESAF is the simulation and analysis software framework developed for the EUSO experiment. ESAF's scope is the whole process of data simulations and data-analysis, from the primary particle interaction in atmosphere to the reconstruction of the event. Based on the ROOT package and designed using Object Oriented technology, ESAF is organized in two main programs: the full montecarlo simulation and the reconstruction framework. The former includes all the relevant physical contributions, shower development in atmosphere, light transport to the detector pupil and detector response, while the latter comprises basic data cleaning, track direction, shower profile and energy reconstruction algorithms. Here we describe the software architecture and its main features

Requirements and simulation study of the performance of EUSO as external payload on board the International Space Station

The "Extreme Universe Space Observatory - EUSO" has been conceived as the first Space mission devoted to the investigation of Ultra High Energy Cosmic Ray, using the Earth's atmosphere as a giant detector. The scientific objectives of the experiment are to observe the UHECR spectrum above the GZK energy, with an improvement of one order of magnitude in the statistics of collected events with respect to the existing experiments, in such a way to study the source distribution in a full sky survey, as well as to open the channel (set a confidence limit) on the neutrino astronomy in this energy range. Supposed to be accommodated as external payload on board the International Space Station, EUSO phase A study has been positively completed in July 2004. Nowadays, due to funding problems of the Space Agencies involved in the project, EUSO is currently on hold. Nevertheless, as result of an end-to-end simulation approach, we summarize here the expected scientific performance coming out from the phase A, as well as the expected improvements in the technical performance of the EUSO Instrument to be achieved during Phase B, in order to fulfil the scientific objectives posed as goal of the experiment

Molecular basis for effects of carcinogenic heavy metals on inducible gene expression.

Certain forms of the heavy metals arsenic and chromium are considered human carcinogens, although they are believed to act through very different mechanisms. Chromium(VI) is believed to act as a classic and mutagenic agent, and DNA/chromatin appears to be the principal target for its effects. In contrast, arsenic(III) is considered nongenotoxic, but is able to target specific cellular proteins, principally through sulfhydryl interactions. We had previously shown that various genotoxic chemical carcinogens, including chromium (VI), preferentially altered expression of several inducible genes but had little or no effect on constitutive gene expression. We were therefore interested in whether these carcinogenic heavy metals might target specific but distinct sites within cells, leading to alterations in gene expression that might contribute to the carcinogenic process. Arsenic(III) and chromium(VI) each significantly altered both basal and hormone-inducible expression of a model inducible gene, phosphoenolpyruvate carboxykinase (PEPCK), at nonovertly toxic doses in the chick embryo in vivo and rat hepatoma H411E cells in culture. We have recently developed two parallel cell culture approaches for examining the molecular basis for these effects. First, we are examining the effects of heavy metals on expression and activation of specific transcription factors known to be involved in regulation of susceptible inducible genes, and have recently observed significant but different effects of arsenic(III) and chromium(VI) on nuclear transcription factor binding. Second, we have developed cell lines with stably integrated PEPCK promoter-luciferase reporter gene constructs to examine effects of heavy metals on promoter function, and have also recently seen profound effects induced by both chromium(VI) and arsenic(III) in this system. These model systems should enable us to be able to identify the critical cis (DNA) and trans (protein) cellular targets of heavy metal exposure leading to alterations in expression of specific susceptible genes. It is anticipated that such information will provide valuable insight into the mechanistic basis for these effects as well as provide sensitive molecular biomarkers for evaluating human exposure

NK cell receptors in anti-tumor and healthy tissue protection: Mechanisms and therapeutic advances

natural killer (NK) cells are integral to the innate immune system, renowned for their ability to target and eliminate cancer cells without the need for antigen presentation, sparing normal tissues. these cells are crucial in cancer immunosurveillance due to their diverse array of activating and inhibitory receptors that modulate their cytotoxic activity. however, the tumor microenvironment can suppress NK cell function through various mechanisms. over recent decades, research has focused on overcoming these tumor escape mechanisms. Initially, efforts concentrated on enhancing T cell activity, leading to impressive results with immunotherapeutic approaches aimed at boosting T cell responses. nevertheless, a substantial number of patients do not benefit from these treatments and continue to seek effective alternatives. In this context, NK cells present a promising avenue for developing new treatments, given their potent cytotoxic capabilities, safety profile, and activity against T cell- resistant tumors, such as those lacking HLA-I expression. recent advancements in immunotherapy include strategies to restore and amplify NK cell activity through immune checkpoint inhibitors, cytokines, adoptive NK cell therapy, and CAR-NK cell technology. this review provides a comprehensive overview of NK cell receptors, the tumor escape mechanisms that hinder NK cell function, and the evolving field of NK cell-based cancer immunotherapy, highlighting ongoing efforts to develop more effective and targeted cancer treatment strategies

Toward polarized antiprotons: Machine development for spin-filtering experiments

The paper describes the commissioning of the experimental equipment and the machine studies required for the first spin-filtering experiment with protons at a beam kinetic energy of $49.3\,$MeV in COSY. The implementation of a low-$\beta$ insertion made it possible to achieve beam lifetimes of $\tau_{\rm{b}}=8000\,$s in the presence of a dense polarized hydrogen storage-cell target of areal density $d_{\rm t}=(5.5\pm 0.2)\times 10^{13}\,\mathrm{atoms/cm^{2}}$. The developed techniques can be directly applied to antiproton machines and allow for the determination of the spin-dependent $\bar{p}p$ cross sections via spin filtering

The landscape of combining immune checkpoint inhibitors with novel Therapies: Secret alliances against breast cancer

this review focuses on the immune checkpoint inhibitors (ICIs) in the context of breast cancer (BC) management. these innovative treatments, by targeting proteins expressed on both tumor and immune cells, aim to overcome tumor-induced immune suppression and reactivate the immune system. the potential of this approach is the subject of numerous clinical studies. here, we explore the key studies and emerging therapies related to ICIs providing a detailed analysis of their specific and combined use in BC treatment