14 research outputs found
Izofloran ve Halotan Anestezisinin Kanin Toraks Cerrahisinde Hemodinamik Dengeye Olan Etkisinin Karşılaştırılması
This study was performed to investigate the effects of isoflurane and halothane
anaesthesia on haemodynamic parameters and blood gases in thorax surgery of
dogs. Twenty, free-living, cross-breed dogs weighing 24.2 ± 4 kg, were equally
divided into two groups as isoflurane and halothane. Atropine sulphate (0.04
mg/kg), xylazine hydrochloride (2 mg/kg) were injected for sedation. Thiopental
sodium (15 mg/kg) and fentanyl citrate (5µg/kg) were injected intravenously for
induction. Dogs were ventilated for 16 times/min to maintain the 15 ml/kg of tidal
volume. A right side thoractomy was performed. Anaesthesia was maintained by
either 1.5 % of isoflurane or halothane. Hearth rate (HR), minimal arterial pressure
(MAP), cardiac output (CO), central venous pressure (CVP), right ventricular
pressure (RVP) pulmonary arterial pressure (PAP), pulmonary capillary wedge
pressure (PCWP) as well as blood gases were recorded at 0, 15, 30, 60 and 120 min.
of the anaesthesia. Significant differences were determined between two groups at
0, 15, 30 and 60 min. in HR and at 0 and 15 min. in PCWP. Hearth rate was
increased at 15 min. in halothane group, and at 30 min in isoflurane group, and
thereafter it returned to the initial levels in both groups. Decreases were determined
in MAP and CO levels in halothane group while MAP levels were stable in
isoflurane group. In conclusion, anaesthesia with isoflurane was safer than the
anaesthesia with halothane in the thoracic surgery of dogs.Bu çalışma köpeklerde toraks cerrahisinde izofloran ve halotan anestezisinin
hemodinamik parametrelere ve kan gazlarına etkisini araştırmak için
gerçekleştirilmiştir.Ağırlıkları 24,2 ± 4 kg olan 20 karışık ırk köpek eşit olarak
izofloran ve halotan grubu olmak üzere 2 ‘ye ayrıldı. Atropin sülfat (0,04 mg/kg,
subkutan) enjeksiyonunu izleyerek ksilazin hidroklorid (2 mg/kg, intramuskuler)
verilmesiyle sedasyon sağlandı. İndüksiyon pentotal sodyum (15 mg/kg ) ve fentanil
sitrat‘ın (5 mcg/kg) intravenöz enjeksiyonuyla sağlandı. Köpekler tidal volüm 15
ml/kg olacak şekilde dakikada 16 kez ventile edildi. Sağ torakotomi her iki grupta
gerçekleştirildi. Anestezi idamesi % 1,5 izofloran ve halotan ile sürdürüldü. Kalp
atım sayısı (HR), ortalama arteriyel kan basıncı (MAP), kardiak debi (CO), santral
venöz basınç (CVP), sağ ventrikül basıncı (RVP), pulmoner arter basıncı (PAP),
pulmoner kapillar veç basıncı (PCWP) ve kan gazları, anestezinin 0, 15, 30, 60 ve
120. dakikalarında kaydedildi. HR’de iki grup arasında 0, 15, 30 ve 60. dakikalarda,
PCWP ise 0 ve 15. dakikalarda fark gözlendi. HR, halotan grubunda 15. dakikada,
izofloran grubunda ise 30. dakikada arttı. Sonraki zamanlarda başlangıç seviyesine
indi. MAP ve CO’da Halotan grubunda düşüş gözlenirken, İzofloran grubunda
stabil kaldı. Sonuç olarak, köpeklerde toraks cerrahisinde izofloran anestezisi
halotan anestezisine göre daha güvenli bulunmuştur
The Effects of Transcranial Electrical Stimulation on Opiate-Induced Analgesia in Rats
BACKGROUND AND OBJECTIVES: Recent experiments have shown that transcranial electrical stimulation significantly increases the potency and duration of the analgesic effects of opioids in humans and rats. In the present study, the influence of transcranial electrical stimulation (TCES) on the analgesic effect of remifentanil hydrochloride (HCl) in rats was determined
A comparative study about hydroxyapatite coated AZ31 and AZ91 Mg alloys
Magnesium alloys are potential candidates for hard tissue replacements due to their structural and mechanical properties close to bone. Unlike conventional metallic implants, the corrosion rate of magnesium is quite high. This will be an advantage if magnesium-based materials are used as biodegradable. In this study, Magnesium-based AZ31 and AZ91 magnesium alloys were coated with hydroxyapatite by plasma spray and electrostatic spray methods and their corrosion rates were compared
Erratum to: Is ursodeoxycholic acid crucial for ischemia/reperfusion-induced ovarian injury in rat ovary?
Manganese-enhanced MRI to evaluate neurodegenerative changes in a rat model of kainic acid-induced excitotoxicity
WOS: 000323750100001PubMed ID: 23886936PURPOSE Manganese-enhanced magnetic resonance imaging (MEMRI) has been used to detect brain activity based on the ability of active neurons to take up manganese ions through calcium channels. Kainic acid (KA), an analog of excitotoxic glutamate, can elicit selective neuronal death in the brains of rodents, of which the pathological changes partially mimic neurodegeneration in the central nervous system. We used in vivo MEMRI to evaluate neurodegenerative changes in an excitotoxicity model induced by KA in rats. MATERIALS AND METHODS Adult Sprague-Dawley rats (220-250 g) were injected with either KA or saline into the right lateral ventricle. Precontrast and postcontrast MEMRI sessions were obtained. Region of interest (ROI) analyses were performed on both injected (saline and KA) and contralateral (normal) sites in the hippocampal area. All brains were evaluated histologically following MEMRI. RESULTS Analysis of percentage change in ROI intensities of T1-weighted fluid-attenuated inversion-recovery MR images in the hippocampal area revealed a significant difference between the KA-injected (ipsilateral) and contralateral sites (P = 0.008), whereas no significant difference was observed between the saline-injected and contralateral sites. Furthermore, there was a significant difference between ipsilateral sites of the saline-treated and KA-treated groups (P = 0.026). The histological results supported these findings. CONCLUSION MEMRI is a simple and useful in vivo method for detecting neurodegenerative changes due to excitotoxicity in the rat brain. The development of a manganese-based contrast agent that can be safely used in humans is warranted to investigate neurological disorders
Izofloran ve Halotan Anestezisinin Kanin Toraks Cerrahisinde Hemodinamik Dengeye Olan Etkisinin Karşılaştırılması
This study was performed to investigate the effects of isoflurane and halothane
anaesthesia on haemodynamic parameters and blood gases in thorax surgery of
dogs. Twenty, free-living, cross-breed dogs weighing 24.2 ± 4 kg, were equally
divided into two groups as isoflurane and halothane. Atropine sulphate (0.04
mg/kg), xylazine hydrochloride (2 mg/kg) were injected for sedation. Thiopental
sodium (15 mg/kg) and fentanyl citrate (5µg/kg) were injected intravenously for
induction. Dogs were ventilated for 16 times/min to maintain the 15 ml/kg of tidal
volume. A right side thoractomy was performed. Anaesthesia was maintained by
either 1.5 % of isoflurane or halothane. Hearth rate (HR), minimal arterial pressure
(MAP), cardiac output (CO), central venous pressure (CVP), right ventricular
pressure (RVP) pulmonary arterial pressure (PAP), pulmonary capillary wedge
pressure (PCWP) as well as blood gases were recorded at 0, 15, 30, 60 and 120 min.
of the anaesthesia. Significant differences were determined between two groups at
0, 15, 30 and 60 min. in HR and at 0 and 15 min. in PCWP. Hearth rate was
increased at 15 min. in halothane group, and at 30 min in isoflurane group, and
thereafter it returned to the initial levels in both groups. Decreases were determined
in MAP and CO levels in halothane group while MAP levels were stable in
isoflurane group. In conclusion, anaesthesia with isoflurane was safer than the
anaesthesia with halothane in the thoracic surgery of dogs.Bu çalışma köpeklerde toraks cerrahisinde izofloran ve halotan anestezisinin
hemodinamik parametrelere ve kan gazlarına etkisini araştırmak için
gerçekleştirilmiştir.Ağırlıkları 24,2 ± 4 kg olan 20 karışık ırk köpek eşit olarak
izofloran ve halotan grubu olmak üzere 2 ‘ye ayrıldı. Atropin sülfat (0,04 mg/kg,
subkutan) enjeksiyonunu izleyerek ksilazin hidroklorid (2 mg/kg, intramuskuler)
verilmesiyle sedasyon sağlandı. İndüksiyon pentotal sodyum (15 mg/kg ) ve fentanil
sitrat‘ın (5 mcg/kg) intravenöz enjeksiyonuyla sağlandı. Köpekler tidal volüm 15
ml/kg olacak şekilde dakikada 16 kez ventile edildi. Sağ torakotomi her iki grupta
gerçekleştirildi. Anestezi idamesi % 1,5 izofloran ve halotan ile sürdürüldü. Kalp
atım sayısı (HR), ortalama arteriyel kan basıncı (MAP), kardiak debi (CO), santral
venöz basınç (CVP), sağ ventrikül basıncı (RVP), pulmoner arter basıncı (PAP),
pulmoner kapillar veç basıncı (PCWP) ve kan gazları, anestezinin 0, 15, 30, 60 ve
120. dakikalarında kaydedildi. HR’de iki grup arasında 0, 15, 30 ve 60. dakikalarda,
PCWP ise 0 ve 15. dakikalarda fark gözlendi. HR, halotan grubunda 15. dakikada,
izofloran grubunda ise 30. dakikada arttı. Sonraki zamanlarda başlangıç seviyesine
indi. MAP ve CO’da Halotan grubunda düşüş gözlenirken, İzofloran grubunda
stabil kaldı. Sonuç olarak, köpeklerde toraks cerrahisinde izofloran anestezisi
halotan anestezisine göre daha güvenli bulunmuştur
The use of manganese-enhanced MRI for the evaluation of neurodegenerative changes in a rat model of kainic acid- induced excitotoxicity
Correlation between endoscopic and histopathological findings in dogs with chronic gastritis
Introduction: Chronic gastritis is a common diagnosis in dogs with signs of chronic vomiting. However, there is no data concerning endoscopic and histopathological agreement in dogs with chronic gastritis. Thus, a question should be raised whether taking gastroduodenal biopsies in dogs with chronic gastritis is necessary or not. Consequently, the purpose of the study was to compare the endoscopic and histopathological agreement in dogs with chronic gastritis. Material and Methods: A total of 22 non-pregnant client-owned dogs with the signs of chronic gastritis were enrolled in this prospective study. Procedures including clinical examination, blood analysis, and diagnostic imaging were performed before anaesthesia. Biopsies obtained from gastroduodenal sites were histopathologically evaluated. A total of 110 gastroduodenal samples were examined. Results: Sixtyeight samples had abnormal histopathology and endoscopy while 11 showed normal histopathological and endoscopic evidence. Conclusion: The obtained data demonstrated that it is not necessary to take extra gastroduodenal biopsies in dogs with evidence of endoscopic gastroduodenitis. We also believe that further prospective studies, including cost and time effectiveness and more specific comparison between endoscopic appearance and histopathology, are necessary to make final recommendations regarding the need of using both procedures for definitive diagnosis
Is ursodeoxycholic acid crucial for ischemia/reperfusion-induced ovarian injury in rat ovary?
Controlled Radical Polymerization of Acrylates Regulated by Visible Light
The controlled radical polymerization of a variety of acrylate monomers is reported using an Ir-catalyzed visible light mediated process leading to well-defined homo-, random, and block copolymers. The polymerizations could be efficiently activated and deactivated using light while maintaining a linear increase in molecular weight with conversion and first order kinetics. The robust nature of the fac-[Ir(ppy)3] catalyst allows carboxylic acids to be directly introduced at the chain ends through functional initiators or along the backbone of random copolymers (controlled process up to 50 mol % acrylic acid incorporation). In contrast to traditional ATRP procedures, low polydispersity block copolymers, poly(acrylate)-b-(acrylate), poly(methacrylate)-b-(acrylate), and poly(acrylate)-b-(methacrylate), could be prepared with no monomer sequence requirements. These results illustrate the increasing generality and utility of light mediated Ir-catalyzed polymerization as a platform for polymer synthesis