Evaluation of acute toxicity of genabilic acid (menbutone 10%) in rabbits

[EN] A complete investigation of the acute toxicity of a choleretic compound, menbutone, was performed in rabbits, including lethal dose for 50% of rabbits determination, clinical signs observation and in vivo and post-mortem examinations. Haematological, biochemical and histopathological changes resulting from intramuscular injection of menbutone were also investigated at dose 400 mg/kg body weight. Acute toxicity of menbutone at dose of 400 mg/kg BW induced interstitial myocarditis and multifocal necrosis, whereas serum creatine phosphokinase, creatinine phosphokinase-MB isoenzyme and aspartate aminotransferase activities were significantly increased. Elevation of serum alanine aminotransferase and alkaline phosphatase activities and total bilirubin level associated with lowered albumin content was consistent with histopathological changes of hepatic tissues; hepatic necrosis and fatty infiltration were pronounced indicators of injuries. Renal tubular necrosis and interstitial nephritis were also observed in intoxicated rabbits. Menbutone also induced variations in some haematological parameters. We concluded that acute toxicity of menbutone in rabbits occurred at accidental high doses, as the lethal dose was about 50 fold over the recommended therapeutic dose for other animals. Cardiac muscle, liver and kidneys are the main target organs for menbutone toxicity. Menbutone is not recommended for use in rabbits suffering from any cardiacand hepatic disorders, especially in overdosing situations.El Okle, SO.; Tohamy, GH.; Lebda, AM. (2014). Evaluation of acute toxicity of genabilic acid (menbutone 10%) in rabbits. World Rabbit Science. 22(3):215-222. doi:10.4995/wrs.2014.1791.SWORD215222223Cardinale, D., Sandri, M. T., Colombo, A., Colombo, N., Boeri, M., Lamantia, G., … Cipolla, C. M. (2004). Prognostic Value of Troponin I in Cardiac Risk Stratification of Cancer Patients Undergoing High-Dose Chemotherapy. Circulation, 109(22), 2749-2754. doi:10.1161/01.cir.0000130926.51766.ccCulling C.F. 1983. Handbook of Histopathological and Histochemical Techniques, 3rd ed. London, Boston: Butterworth.De la Cruz-Hernández N.I., Argudín-Salomón O.A., Zertuche- Rodríguez J.L., Medellín-Ledezma J.A., Flores-Gutiérrez G.H. 2012. Case report: outbreak of sodium monensin intoxication in feedlot cattle from Mexico. Revue Med. Vet., 163: 60-63.Pershin G.N. 1971. Methods of experimental chemotherapy: Practical guidance, 2nd edition, Moscow. Russia: Medicina

Внедрение и принцип работы системы сейсмического мониторинга горного массива для работы в условиях ООО "Шахта "Усковская"

The status of the Silicon Microvertex Detector (SMD) and its installation into the LEP-L3 experiment are presented, highlighting novel features and sophisticated techniques. Preliminary results based on 1993 data are given and compared with Monte Carlo predictions, to understand the detector performances and its tracking capabilities

The forward muon detector of L3

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