R&D Status of Nuclear Emulsion For Directional Dark Matter Search

In this study, we are doing R&D for directional dark matter search with nuclear emulsion. First of all, higher resolution nuclear emulsion with fine silver halide crystals was developed in the production facility of emulsion at Nagoya university, and we confirmed that it can detect the expected nuclear recoil tracks. The readout of submicron tracks was required the new technology. We developed the expansion technique, and could readout the signal by shape analysis with optical microscopy. The two dimensional angular resolution is 36 degrees at the original track length of range from 150nm to 200nm with optical microscopy. Finally we demonstrated by using recoiled nuclei induced by 14.8MeV neutron, and confirmed the technique.Moreover, we developed the X-ray microscope system with SPring-8 as final check with higher resolution of selected candidate tracks with optical microscopy. The angular resolution was improved from 31 degrees with optical microscopy to 17degrees with X-ray microscopy at the track length of range from 150nm to 250nm. We are developing the practical system and planning for start of the test running with prototype detector.Comment: Proceedings of the 3rd International conference on Directional Detection of Dark Matter (CYGNUS 2011), Aussois, France, 8-10 June 201

Space debris executive summary

Spacecraft, boosters, and fragments are potential hazards to space vehicles, and it is argued that collisions between them could produce a cascade that could preclude activity in LEO in 25 to 50 years. That has generated pressure for constraints on military space operations, so the AF SAB performed a study of technical aspects of the debris problem. The Study was independent of the efforts of the Air Force Space Command (AFSPC) as well as those of and NASA Johnson Space Center (JSC), which is the principal advocate for cascades and constraints. Most work on space debris has been performed by AFSPC and JSC, so the Study was in part an assessment of their efforts, in which both have been cooperative. The Study identified the main disagreements and quantified their impacts. It resolved some issues and provided bounds for the rest. It treated radar and optical observations; launch, explosion, and decay rates; and the number and distribution of fragments from explosions and collisions. That made it possible to address hazard to manned spacecraft at low altitudes and the possibility of cascading at higher altitudes, both of which now appear less likely

72 Multicenter clinical evaluation of the HeartMate II axial flow left ventricular assist device in patients with severe heart failure: hemodynamic effects, pump performance and quality of life

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106728/1/ehfs80038-x.pd

M-Theory solutions with AdS factors

Solutions of D=7 maximal gauged supergravity are constructed with metrics that are a product of a n-dimensional anti-de Sitter (AdS) space, with n=2,3,4,5, and certain Einstein manifolds. The gauge fields have the same form as in the recently constructed solutions describing the near-horizon limits of M5-branes wrapping supersymmetric cycles. The new solutions do not preserve any supersymmetry and can be uplifted to obtain new solutions of D=11 supergravity, which are warped and twisted products of the D=7 metric with a squashed four-sphere. Some aspects of the stability of the solutions are discussed.Comment: 30 pages. References adde

Environmental sub-MeV neutron measurement at the Gran Sasso surface laboratory with a super-fine-grained nuclear emulsion detector

The measurement of environmental neutrons is particularly important in the search for new physics, such as dark matter particles, because neutrons constitute an often-irreducible background source. The measurement of the neutron energy spectra in the sub-MeV scale is technically difficult because it requires a very good energy resolution and a very high $\gamma$-ray rejection power. In this study, we used a super-fine-grained nuclear emulsion, called Nano Imaging Tracker (NIT), as a neutron detector. The main target of neutrons is the hydrogen (proton) content of emulsion films. Through a topological analysis, proton recoils induced by neutron scattering can be detected as tracks with sub-micrometric accuracy. This method shows an extremely high $\gamma$-ray rejection power, at the level of $5 \times 10^7 ~ \gamma/\rm{cm}^2$, which is equivalent to 5 years accumulation of environmental $\gamma$-rays, and a very good energy and direction resolution even in the sub-MeV energy region. In order to carry out this measurement with sufficient statistics, we upgraded the automated scanning system to achieve a speed of 250 g/year/machine. We calibrated the detector performance of this system with 880 keV monochromatic neutrons: a very good agreement with the expectation was found for all the relevant kinematic variables. The application of the developed method to a sample exposed at the INFN Gran Sasso surface laboratory provided the first measurement of sub-MeV environmental neutrons with a flux of $(7.6 \pm 1.7) \times 10^{-3} \rm{cm}^{-2} \rm{s}^{-1}$ in the proton energy range between 0.25 and 1 MeV (corresponds to neutron energy range between 0.25 and 10 MeV), consistent with the prediction. The neutron energy and direction distributions also show a good agreement.Comment: 11 pages, 14 figure

AdS spacetimes from wrapped D3-branes

We derive a geometrical characterisation of a large class of AdS_3 and AdS_2 supersymmetric spacetimes in IIB supergravity with non-vanishing five-form flux using G-structures. These are obtained as special cases of a class of supersymmetric spacetimes with an $\mathbb{R}^{1,1}$ or $\mathbb{R}$ (time) factor that are associated with D3-branes wrapping calibrated 2- or 3- cycles, respectively, in manifolds with SU(2), SU(3), SU(4) and G_2 holonomy. We show how two explicit AdS solutions, previously constructed in gauged supergravity, satisfy our more general G-structure conditions. For each explicit solution we also derive a special holonomy metric which, although singular, has an appropriate calibrated cycle. After analytic continuation, some of the classes of AdS spacetimes give rise to known classes of BPS bubble solutions with $\mathbb{R}\times SO(4)\times SO(4)$, $\mathbb{R}\times SO(4)\times U(1)$, and $\mathbb{R}\times SO(4)$ symmetry. These have 1/2, 1/4 and 1/8 supersymmetry, respectively. We present a new class of 1/8 BPS geometries with $\mathbb{R}\times SU(2)$ symmetry, obtained by analytic continuation of the class of AdS spacetimes associated with D3-branes wrapped on associative three-cycles.Comment: 1+30 pages; v2, references added; v3, typos corrected, reference adde

Multiscale - Patient-Specific Artery and Atherogenesis Models

In this work, we present a platform for the development of multiscale patient-specific artery and atherogenesis models. The platform, called ARTool, integrates technologies of 3-D image reconstruction from various image modalities, blood flow and biological models of mass transfer, plaque characterization, and plaque growth. Patient images are acquired for the development of the 3-D model of the patient specific arteries. Then, blood flow ismodeled within the arterial models for the calculation of the wall shear stress distribution (WSS). WSS is combined with other patient-specific parameters for the development of the plaque progression models. Real-time simulation can be performed for same cases in grid environment. The platform is evaluated using both animal and human data

Context-dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cancer cells

RUNX3 is a tumor suppressor for a variety of cancers. RUNX3 suppresses the canonical Wnt signaling pathway by binding to the TCF4/β-catenin complex, resulting in the inhibition of binding of the complex to the Wnt target gene promoter. Here, we confirmed that RUNX3 suppressed Wnt signaling activity in several gastric cancer cell lines; however, we found that RUNX3 increased the Wnt signaling activity in KatoIII and SNU668 gastric cancer cells. Notably, RUNX3 expression increased the ratio of the Wnt signaling-high population in the KatoIII cells. although the maximum Wnt activation level of individual cells was similar to that in the control. As found previously, RUNX3 also binds to TCF4 and β-catenin in KatoIII cells, suggesting that these molecules form a ternary complex. Moreover, the ChIP analyses revealed that TCF4, β-catenin and RUNX3 bind the promoter region of the Wnt target genes, Axin2 and c-Myc, and the occupancy of TCF4 and β-catenin in these promoter regions is increased by the RUNX3 expression. These results suggest that RUNX3 stabilizes the TCF4/β-catenin complex on the Wnt target gene promoter in KatoIII cells, leading to activation of Wnt signaling. Although RUNX3 increased the Wnt signaling activity, its expression resulted in suppression of tumorigenesis of KatoIII cells, indicating that RUNX3 plays a tumor-suppressing role in KatoIII cells through a Wnt-independent mechanism. These results indicate that RUNX3 can either suppress or activate the Wnt signaling pathway through its binding to the TCF4/β-catenin complex by cell context-dependent mechanisms. © 2014 The Authors

Measuring Black Hole Formations by Entanglement Entropy via Coarse-Graining

We argue that the entanglement entropy offers us a useful coarse-grained entropy in time-dependent AdS/CFT. We show that the total von-Neumann entropy remains vanishing even when a black hole is created in a gravity dual, being consistent with the fact that its corresponding CFT is described by a time-dependent pure state. We analytically calculate the time evolution of entanglement entropy for a free Dirac fermion on a circle following a quantum quench. This is interpreted as a toy holographic dual of black hole creations and annihilations. It is manifestly free from the black hole information problem.Comment: 25 pages, Latex, 8 figure