Iel Dit Quoi ? A Study of the Emergence and Acceptance of Gender Neutral Language in the Francophone World. Case Study: France versus Canada

How has gender neutral language evolved in French, and how is it being used and accepted today? Examining 3 aspects: Gender and Job Titles L’écriture inclusive Gender Neutral Pronounshttps://egrove.olemiss.edu/hon_posters/1004/thumbnail.jp

High-energy effective theory for matter on close Randall Sundrum branes

Extending the analysis of hep-th/0504128, we obtain a formal expression for the coupling between brane matter and the radion in a Randall-Sundrum braneworld. This effective theory is correct to all orders in derivatives of the radion in the limit of small brane separation, and, in particular, contains no higher than second derivatives. In the case of cosmological symmetry the theory can be obtained in closed form and reproduces the five-dimensional behaviour. Perturbations in the tensor and scalar sectors are then studied. When the branes are moving, the effective Newtonian constant on the brane is shown to depend both on the distance between the branes and on their velocity. In the small distance limit, we compute the exact dependence between the four-dimensional and the five-dimensional Newtonian constants.Comment: Updated version as published in PR

DIA-based systems biology approach unveils E3 ubiquitin ligase-dependent responses to a metabolic shift

The yeast Saccharomyces cerevisiae is a powerful model system for systems-wide biology screens and large-scale proteomics methods. Nearly complete proteomics coverage has been achieved owing to advances in mass spectrometry. However, it remains challenging to scale this technology for rapid and high-throughput analysis of the yeast proteome to investigate biological pathways on a global scale. Here we describe a systems biology workflow employing plate-based sample preparation and rapid, single-run, data-independent mass spectrometry analysis (DIA). Our approach is straightforward, easy to implement, and enables quantitative profiling and comparisons of hundreds of nearly complete yeast proteomes in only a few days. We evaluate its capability by characterizing changes in the yeast proteome in response to environmental perturbations, identifying distinct responses to each of them and providing a comprehensive resource of these responses. Apart from rapidly recapitulating previously observed responses, we characterized carbon source-dependent regulation of the GID E3 ligase, an important regulator of cellular metabolism during the switch between gluconeogenic and glycolytic growth conditions. This unveiled regulatory targets of the GID ligase during a metabolic switch. Our comprehensive yeast system readout pinpointed effects of a single deletion or point mutation in the GID complex on the global proteome, allowing the identification and validation of targets of the GID E3 ligase. Moreover, this approach allowed the identification of targets from multiple cellular pathways that display distinct patterns of regulation. Although developed in yeast, rapid whole-proteome–based readouts can serve as comprehensive systems-level assays in all cellular systems

Bulk inflaton shadows of vacuum gravity

We introduce a $(5+m)$-dimensional vacuum description of five-dimensional bulk inflaton models with exponential potentials that makes analysis of cosmological perturbations simple and transparent. We show that various solutions, including the power-law inflation model recently discovered by Koyama and Takahashi, are generated from known $(5+m)$-dimensional vacuum solutions of pure gravity. We derive master equations for all types of perturbations, and each of them becomes a second order differential equation for one master variable supplemented by simple boundary conditions on the brane. One exception is the case for massive modes of scalar perturbations. In this case, there are two independent degrees of freedom, and in general it is difficult to disentangle them into two separate sectors.Comment: 22 pages, 4 figures, revtex; v2: references adde