A Systematic Review on the Extent and Quality of Pharmacoeconomic Publications in Egypt.

BACKGROUND: Egypt faces many challenges when matching patient needs with available resources. Consequently, there has been an increasing interest in pharmacoeconomics as an aid tool in health decision-making to better allocate resources. OBJECTIVES: To review and evaluate the volume and the quality of published pharmacoeconomic studies in Egypt. METHODS: A literature search was conducted in August 2018 using PubMed, Google Scholar, and Cochrane library to identify published Egyptian pharmacoeconomic studies. Articles were included if they were original economic studies, written and published in English, and conducted in Egypt. Each article was assessed independently by two reviewers using the 100-point Quality of Health Evaluation Studies (QHES) scale. RESULTS: Fifteen studies published between 2002 and 2017 were included in the review. Most of them were cost-effectiveness analyses (60%). The minority used secondary data (33.3%) or adopted modeling techniques (40%). The mean QHES score of the included studies was 70.1 ± 21.8, and approximately 40% of them had a QHES score of more than 80. CONCLUSION: Pharmacoeconomic evaluations in Egypt are still in their infancy. The Egyptian guidelines for economic evaluation should be adopted and the EQ-5D-5L value sets should be developed to increase the quality of economic research

Hyper-compressions: The rise of flash fiction in “post-transitional” South Africa

Blair, P. (2020). Hyper-compressions: The rise of flash fiction in “post-transitional” South Africa', The Journal of Commonwealth Literature, 55(1), 38-60. Copyright © 2018. Reprinted by permission of SAGE Publications.This article begins with a survey of flash fiction in “post-transitional” South Africa, which it relates to the nation’s post-apartheid canon of short stories and short-short stories, to the international rise of flash fiction and “sudden fiction”, and to the historical particularities of South Africa’s “post-transition”. It then undertakes close readings of three flash fictions republished in the article, each less than 450 words: Tony Eprile’s “The interpreter for the tribunal” (2007), which evokes the psychological and ethical complexities, and long-term ramifications, of the Truth and Reconciliation Commission; Michael Cawood Green’s “Music for a new society” (2008), a carjacking story that invokes discourses about violent crime and the “‘new’ South Africa”; and Stacy Hardy’s “Kisula” (2015), which maps the psychogeography of cross-racial sex and transnational identity-formation in an evolving urban environment. The article argues that these exemplary flashes are “hyper-compressions”, in that they compress and develop complex themes with a long literary history and a wide contemporary currency. It therefore contends that flash fiction of South Africa’s post-transition should be recognized as having literary-historical significance, not just as an inherently metonymic form that reflects, and alludes to, a broader literary culture, but as a genre in its own right

Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner

Multiple ovulations are uncommon in humans, cattle and many breeds of sheep. Pituitary gonadotrophins and as yet unidentified ovarian factors precisely regulate follicular development so that, normally, only one follicle is selected to ovulate. The Inverdale (FecX(I)) sheep, however, carries a naturally occurring X-linked mutation that causes increased ovulation rate and twin and triplet births in heterozygotes (FecX(I)/FecX(+); ref. 1). but primary ovarian failure in homozygotes (FecX(I)/FecX(I); ref. 2). Germcell development, formation of the follicle and the earliest stages of follicular growth are normal in FecX(I)/FecX(I) sheep, but follicular development beyond the primary stage is impaired(3,4). A second family unrelated to the Inverdale sheep also has the same X-linked phenotype(5) (Hanna, FecX(H)). Crossing FecX(I) with FecXH animals produces FecX(I)/FecX(H) infertile females phenotypically indistinguishable from FecX(I)/FecX(I) females(6). We report here that the FecX(I) locus maps to an orthologous chromosomal region syntenic to human Xp11.2-11.4, which contains BMP15, encoding bone morphogenetic protein 15 (also known as growth differentiation factor 9B (GDF9B)). Whereas BMP15 is a member of the transforming growth factor beta (TGF beta) superfamily and is specifically expressed in oocytes, its function is unknown(7-9). We show that independent germline point mutations exist in FecX(I) and FecX(H) carriers. These findings establish that BMP15 is essential for female fertility and that natural mutations in an ovary-derived factor can cause both increased ovulation rate and infertility phenotypes in a dosage-sensitive manner

Finding Ivan Vladislavić - Writing the city

The work of Ivan Vladislavić is well established in his native South Africa, and increasingly recognized on the larger world stage of writing, editing and publishing. If his work nevertheless eludes scrutiny in some quarters, this may also have to do with its nature, and not only with its origin. The works differ and vary; there is no formula or project which proceeds neatly by sequence. No single work can be second-guessed from any other. This is a project full of surprises, connecting variously to art, photography, architecture and to urban studies, setting to work images and practices at once realist and surreal, absurdist and layering, and given to time and place and the universal. How then do we read it, and how does he write? For the purposes of this paper, we explain and locate our enthusiasm with reference to two works, The Restless Supermarket (2001) and Portrait with Keys (2006). We seek to identify some key tropes about place and place-writing and cities and city-writing with reference to Johannesburg and the way in which Vladislavic plays his subjects and his readers, placing not only fiction (or realism) under question but placing writing itself closer to the editor's deletion mark. This may be, we suggest, a kind of writing sideways. © Thesis Eleven Pty, Ltd., SAGE Publications