OFFICIAL MEDICATIONS FOR ANTI-TUMOR GENE THERAPY

This is a review of modern literature data of official medications for anti-tumor gene therapy as well as of medications that finished clinical trials.The article discusses the concept of gene therapy, the statistical analysis results of initiated clinical trials of gene products, the most actively developing directions of anticancer gene therapy, and the characteristics of anti-tumor gene medications.Various delivery systems for gene material are being examined, including viruses that are defective in  replication (Gendicine™ and Advexin) and oncolytic (tumor specific conditionally replicating) viruses (Oncorine™, ONYX-015, Imlygic®).By now three preparations for intra-tumor injection have been introduced into oncology clinical practice: two of them – Gendicine™ and Oncorine™ have been registered in China, and one of them – Imlygic® has been registered in the USA. Gendicine™ and Oncorine™ are based on the wild type p53 gene and are designed for treatment of patients with head and neck malignancies. Replicating adenovirus is the delivery system in Gendicine™, whereas oncolytic adenovirus is the vector for gene material in Oncorine™. Imlygic® is based on the  recombinant replicating HSV1 virus with an introduced GM–CSF gene and is designed for treatment of  melanoma patients. These medications are well tolerated and do not cause any serious adverse events. Gendicine™ and Oncorine™ are not effective in monotherapy but demonstrate pronounced synergism with chemoand radiation therapy. Imlygic® has just started the post marketing trials

Inclusion as a form of social inequality overcoming in the educational environment

© 2017 Serials Publications.The urgency of the study is caused by the need for social adaptation of people with disabilities, their education and development. A serious problem here is the acceptance by the society of this category of citizens as its equal members. The aim of the paper is to identify the readiness of Russian society, in particular the higher education system, to implement inclusive education. The authors disclose the concepts of inclusion and inclusive education, transparent to the modern social situation. Two models of disability are proposed - medical (defining disability through the presence of health disorders) and social (defining people with disabilities or disorders due to physical or organizational barriers in society, prejudices and stereotypes). The main activity within the medical model is the minimization or reduction of violations through medical intervention and therapy. The social model promotes the equality of all members of society and the provision of equal opportunities for all in obtaining education, above all. The paper presents data obtained in the course of sociological studies conducted, among others, by public organizations of disabled people. The authors propose a way of social inequality overcoming through the implementation of inclusive education. The materials of the paper are intended for heads of educational organizations, teachers, psychologists, employees of social services

Antimicrobial resistance in clinical <I>Escherichia coli</I> isolates obtained from animals

The article presents data on the phenotypic and genotypic characteristics of antimicriobial resistance in Escherichia coli clinical isolates recovered from bovine microbiota (secretions from mammary glands, cervical swabs). 127 Escherichia coli isolates were studied, i.e. 44 from mammary glands secretions and 83 from cervical swabs. Disk diffusion method was used to study antimicrobial resistance of the cultures; minimum inhibitory concentrations of antimicrobials were determined in a serial dilution method; resistance genes were detected by polymerase chain reaction. The carried out research demonstrates a wide distribution of the isolates belonging to the phenotype resistant to ansamycins (rifampicin), semi-synthetic penicillins (ampicillin and amoxicillin), tetracyclines (doxycycline). The isolates showed a lower level of resistance to macrolides (azithromycin), amphenicols (levomycetin) and aminoglycosides (tobramycin). It was found that Escherichia coli clinical isolates are sensitive to third-generation cephalosporins and fluoroquinolone antimicrobials. However, since 28.46% of cultures demonstrate intermediate resistance to third-generation cephalosporins and 49.02% of Escherichia coli DNA samples isolated from mammal gland secretions had blaDHA gene associated with resistance to this group of antimicrobials, these antimicrobials could be hardly recommended as antibiotics of choice. Absence of VIM carbapenemase-encoding gene in the DNA of the recovered isolates and a low level of phenotypic resistance (10.22% of isolates from cervical swabs) can be one of the reasons for recommending first-line carbapenems as antibiotics of choice to treat animal diseases associated with Escherichia coli, along with fluoroquinolones as reserve antimicrobials. It was found that the recovered Escherichia coli isolates are more sensitive to combination antibiotics than to mono-antibiotics

Inclusion as a form of social inequality overcoming in the educational environment

© 2017 Serials Publications.The urgency of the study is caused by the need for social adaptation of people with disabilities, their education and development. A serious problem here is the acceptance by the society of this category of citizens as its equal members. The aim of the paper is to identify the readiness of Russian society, in particular the higher education system, to implement inclusive education. The authors disclose the concepts of inclusion and inclusive education, transparent to the modern social situation. Two models of disability are proposed - medical (defining disability through the presence of health disorders) and social (defining people with disabilities or disorders due to physical or organizational barriers in society, prejudices and stereotypes). The main activity within the medical model is the minimization or reduction of violations through medical intervention and therapy. The social model promotes the equality of all members of society and the provision of equal opportunities for all in obtaining education, above all. The paper presents data obtained in the course of sociological studies conducted, among others, by public organizations of disabled people. The authors propose a way of social inequality overcoming through the implementation of inclusive education. The materials of the paper are intended for heads of educational organizations, teachers, psychologists, employees of social services

Inclusion as a form of social inequality overcoming in the educational environment

© 2017 Serials Publications.The urgency of the study is caused by the need for social adaptation of people with disabilities, their education and development. A serious problem here is the acceptance by the society of this category of citizens as its equal members. The aim of the paper is to identify the readiness of Russian society, in particular the higher education system, to implement inclusive education. The authors disclose the concepts of inclusion and inclusive education, transparent to the modern social situation. Two models of disability are proposed - medical (defining disability through the presence of health disorders) and social (defining people with disabilities or disorders due to physical or organizational barriers in society, prejudices and stereotypes). The main activity within the medical model is the minimization or reduction of violations through medical intervention and therapy. The social model promotes the equality of all members of society and the provision of equal opportunities for all in obtaining education, above all. The paper presents data obtained in the course of sociological studies conducted, among others, by public organizations of disabled people. The authors propose a way of social inequality overcoming through the implementation of inclusive education. The materials of the paper are intended for heads of educational organizations, teachers, psychologists, employees of social services

Inclusion as a form of social inequality overcoming in the educational environment

© 2017 Serials Publications.The urgency of the study is caused by the need for social adaptation of people with disabilities, their education and development. A serious problem here is the acceptance by the society of this category of citizens as its equal members. The aim of the paper is to identify the readiness of Russian society, in particular the higher education system, to implement inclusive education. The authors disclose the concepts of inclusion and inclusive education, transparent to the modern social situation. Two models of disability are proposed - medical (defining disability through the presence of health disorders) and social (defining people with disabilities or disorders due to physical or organizational barriers in society, prejudices and stereotypes). The main activity within the medical model is the minimization or reduction of violations through medical intervention and therapy. The social model promotes the equality of all members of society and the provision of equal opportunities for all in obtaining education, above all. The paper presents data obtained in the course of sociological studies conducted, among others, by public organizations of disabled people. The authors propose a way of social inequality overcoming through the implementation of inclusive education. The materials of the paper are intended for heads of educational organizations, teachers, psychologists, employees of social services

Development of an experimental plant and a numerical model of an axial magnetic rotor suspension

This article presents the results of the work on the creation of an experimental plant, its testing, as well as the development of a computational model of a rotor magnetic suspension with the use of axial electromagnets. The main purpose of producing the plant was to test the results of the developed numerical finite element model. An automatic control system was developed for the experimental installation. The electrical circuit was assembled on the basis of a ESP32 microcontroller with a clock frequency of 240 MHz and a PWM with a capacity of 10 bits. A PID-regulator program was developed. The coefficients kP, kD, kI used in the code of the electronic control system program (PID-controller) were selected. An experimental study of the bearing capacity of the axial active magnetic bearing under the influence of an external axial force was conducted. The required power of the axial active magnetic bearing was determined. The maximum load-bearing capacity of the installation for the selected coefficients of the PID-controller was determined. An axisymmetric finite-element model of the axial active magnetic bearing was created in the open-source program FEMM 4.2. The load-bearing capacity of the installation for a given current intensity value was calculated. The results of the numerical modelling were compared with the experimental data obtained. The basic principles of creation and operation of the experimental plant and its numerical model are outlined