Minimum drinking age laws effects on American youth 1976-1987

https://deepblue.lib.umich.edu/bitstream/2027.42/137895/1/occ28.pd

Unbound states of 32Cl and the 31S(p,\gamma)32Cl reaction rate

The 31S(p,\gamma)32Cl reaction is expected to provide the dominant break-out path from the SiP cycle in novae and is important for understanding enrichments of sulfur observed in some nova ejecta. We studied the 32S(3He,t)32Cl charge-exchange reaction to determine properties of proton-unbound levels in 32Cl that have previously contributed significant uncertainties to the 31S(p,\gamma)32Cl reaction rate. Measured triton magnetic rigidities were used to determine excitation energies in 32Cl. Proton-branching ratios were obtained by detecting decay protons from unbound 32Cl states in coincidence with tritons. An improved 31S(p,\gamma)32Cl reaction rate was calculated including robust statistical and systematic uncertainties

Analytic regularity for a singularly perturbed system of reaction-diffusion equations with multiple scales: proofs

We consider a coupled system of two singularly perturbed reaction-diffusion equations, with two small parameters $0< \epsilon \le \mu \le 1$, each multiplying the highest derivative in the equations. The presence of these parameters causes the solution(s) to have \emph{boundary layers} which overlap and interact, based on the relative size of $\epsilon$ and $$. We construct full asymptotic expansions together with error bounds that cover the complete range $0 < \epsilon \leq \mu \leq 1$. For the present case of analytic input data, we derive derivative growth estimates for the terms of the asymptotic expansion that are explicit in the perturbation parameters and the expansion order

12-h clock regulation of genetic information flow by XBP1s

© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Pan, Y., Ballance, H., Meng, H., Gonzalez, N., Kim, S., Abdurehman, L., York, B., Chen, X., Schnytzer, Y., Levy, O., Dacso, C. C., McClung, C. A., O'Malley, B. W., Liu, S., & Zhu, B. 12-h clock regulation of genetic information flow by XBP1s. Plos Biology, 18(1), (2020): e3000580, doi:10.1371/journal.pbio.3000580.Our group recently characterized a cell-autonomous mammalian 12-h clock independent from the circadian clock, but its function and mechanism of regulation remain poorly understood. Here, we show that in mouse liver, transcriptional regulation significantly contributes to the establishment of 12-h rhythms of mRNA expression in a manner dependent on Spliced Form of X-box Binding Protein 1 (XBP1s). Mechanistically, the motif stringency of XBP1s promoter binding sites dictates XBP1s’s ability to drive 12-h rhythms of nascent mRNA transcription at dawn and dusk, which are enriched for basal transcription regulation, mRNA processing and export, ribosome biogenesis, translation initiation, and protein processing/sorting in the Endoplasmic Reticulum (ER)-Golgi in a temporal order consistent with the progressive molecular processing sequence described by the central dogma information flow (CEDIF). We further identified GA-binding proteins (GABPs) as putative novel transcriptional regulators driving 12-h rhythms of gene expression with more diverse phases. These 12-h rhythms of gene expression are cell autonomous and evolutionarily conserved in marine animals possessing a circatidal clock. Our results demonstrate an evolutionarily conserved, intricate network of transcriptional control of the mammalian 12-h clock that mediates diverse biological pathways. We speculate that the 12-h clock is coopted to accommodate elevated gene expression and processing in mammals at the two rush hours, with the particular genes processed at each rush hour regulated by the circadian and/or tissue-specific pathways.This study was supported by the American Diabetes Association junior faculty development award 1-18-JDF-025 to B.Z., by funding from National Institute of Health HD07879 and 1P01DK113954 to B.W.O, by funding from National Science Foundation award 1703170 to C.C.D. and B.Z., and by funding from Brockman Foundation to C.C.D and B.W.O. This work was further supported by the UPMC Genome Center with funding from UPMC’s Immunotherapy and Transplant Center. This research was supported in part by the University of Pittsburgh Center for Research Computing through the resources provided. Research reported in this publication was further supported by the National Institute of Diabetes And Digestive And Kidney Diseases of the National Institutes of Health under award number P30DK120531 to Pittsburgh Liver Research Center, in which both S.L. and B.Z. are members. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Excitation of superconducting qubits from hot non-equilibrium quasiparticles

Superconducting qubits probe environmental defects such as non-equilibrium quasiparticles, an important source of decoherence. We show that "hot" non-equilibrium quasiparticles, with energies above the superconducting gap, affect qubits differently from quasiparticles at the gap, implying qubits can probe the dynamic quasiparticle energy distribution. For hot quasiparticles, we predict a non-neligable increase in the qubit excited state probability P_e. By injecting hot quasiparticles into a qubit, we experimentally measure an increase of P_e in semi-quantitative agreement with the model and rule out the typically assumed thermal distribution.Comment: Main paper: 5 pages, 5 figures. Supplement: 1 page, 1 figure, 1 table. Updated to user-prepared accepted version. Key changes: Supplement added, Introduction rewritten, Figs.2,3,5 revised, Fig.4 adde

CE19010

The WESPAS survey program is the consolidation of two existing survey programs carried out by FEAS. The Malin Shelf herring acoustic survey has been carried out annually since 2008 and reports on the annual abundance of summer feeding aggregations of herring to the west of Scotland and to the north and west of Ireland from 54°N to 58°30’N. The boarfish survey was carried out from 2011 using a chartered fishing vessel and reports on the abundance of spawning aggregations of boarfish from 47°N to 57°N. In 2016 both surveys were combined and carried out onboard the RV Celtic Explorer over a 42 day period providing synoptic coverage of shelf waters from 47°N northwards to 58°30’N

Drug use among black, white, Hispanic, Native American, and Asian American high school seniors (1976-1989): Prevalence, trends, and correlates (rev. ed.)

https://deepblue.lib.umich.edu/bitstream/2027.42/137893/1/occ30.pd

CE18010

The WESPAS survey program is the consolidation of two existing survey programs carried out by FEAS, the Malin Shelf herring acoustic survey and the boarfish acoustic survey. The Malin Shelf herring acoustic survey has been carried out annually since 2008 and reports on the annual abundance of summer feeding aggregations of herring to the west of Scotland and to the north and west of Ireland from 54°N to 58°30’N. The boarfish survey was conducted from 2011 using a chartered fishing vessel and reported the abundance of spawning aggregations of boarfish from 47°N to 57°N. In 2016 both surveys were combined and since then have been carried out onboard the RV Celtic Explorer over a 42 day period providing synoptic coverage of shelf waters from 47°N northwards to 58°30’N. Age stratified relative stock abundance estimates of boarfish, herring and horse mackerel within the survey area were calculated using acoustic data and biological data from trawl sampling. Stock estimates of boarfish and horse mackerel were submitted to the ICES assessment Working Group for Widely Distributed Stocks (WGWIDE) meeting in August 2018. Herring estimates are submitted to the Herring Assessment Working Group (HAWG) meeting in March every year. Survey performance will be reviewed at the ICES Planning Group meeting for International Pelagic Surveys (WGIPS) meeting in January 2019

Analysing experienced and inexperienced cyclists’ attentional focus and self-regulatory strategies during varying intensities of fixed perceived effort cycling: A mixed method study

Using a think aloud approach during fixed perceived effort exercise is a unique method to explore the decisionmaking processes that guide the self-regulation of perceived effort during endurance-based activity. In a two-part study, authors investigated the attentional focus and self-regulatory strategies associated with: Part A - perceived effort corresponding to (RPEGET) and above gas exchange threshold (RPE+15%GET); Part B - between experienced and inexperienced cyclists during fixed perceived effort cycling tasks. Eighteen (15 male, 3 female) healthy, active individuals completed three visits (visit 1 – ramped incremental test and familiarisation, visit 2 and 3–30-min fixed perceived effort cycling). During which, power output, heart rate, lactate, think aloud, and perceptual markers were taken. Random-intercepts linear mixed-effects models assessed the condition, time, and condition × time interactions on all dependent variables. Power output, heart rate, lactate and instances of internal sensory monitoring (t195 = 2.57, p = .011, β = 0.95 [0.23, 1.68]) and self-regulation (t195 = 4.14, p = .001, β = 1.69 [0.89, 2.49]) were significantly higher in the RPE+15%GET versus RPEGET trial. No significant differences between inexperienced and experienced cyclists for internal sensory monitoring (t196 = − 1.78, p = .095, β = − 1.73 [− 3.64, 0.18]) or self-regulatory thoughts (t196 = − 0.39, p = .699, β = − 1.06 [− 6.32, 4.21]) were noted but there were significant condition × time interactions for internal monitoring (t196 = 2.02, p = .045, β = 0.44 [0.01, 0.87]) and self-regulation (t196 = 3.45, p = .001, β = 0.85 [0.37, 1.33]). Seemingly, experienced athletes associatively attended to internal psychophysiological state and subsequently self-regulate their psychophysiological state at earlier stages of exercise than inexperienced athletes. This is the first study to exhibit the differences in attentional focus and self-regulatory strategies that are activated based on perceived effort intensity and experience level in cyclists