12 research outputs found
A phase II study of the modulation of 5-fluorouracil and folinic acid with high-dose infusional hydroxyurea in metastatic colorectal carcinoma
POTENTIAL ERGOGENIC ACTIVITY OF GRAPE JUICE IN RUNNERS
Recent studies have indicated that certain food products have ergogenic potential similar to that of sports supplements. The present study aimed to investigate the potential ergogenic effect of integral purple grape juice on the performance of recreational runners. Twenty eight volunteers of both genders (39.8 ± 8.5 years; peak oxygen consumption [VO2peak] of 43.2 ± 8.5 mL/kg/min) were randomized into either a group that received grape juice (grape juice group â GJG, n=15; 10 mL/kg/min for 28 days) or a group that received an isocaloric, isoglycemic and isovolumetric control beverage (control group â CG, n=13). A time-to-exhaustion exercise test, anaerobic threshold test and aerobic capacity test were performed, together with assessments of markers of oxidative stress, inflammation, immune response and muscle injury, performed at baseline and 48 hours after the supplementation protocol. The GJG showed a significant increase (15.3%) in running time-to-exhaustion (p=0.002) without significant improvements in either anaerobic threshold (3.6%; p=0.511) or aerobic capacity (2.2%; p=0.605). In addition, GJG exhibited significant increases in total antioxidant capacity (38.7%; p=0.009), vitamin A (11.8%; p=0.016) and uric acid (28.2%; p=0.005), whereas alpha-1-acid glycoprotein significantly decreased (20.2%; p=0.006) and high-sensitivity C-reactive protein levels remained unchanged. In contrast, no significant changes occurred in any of these variables in the CG. Concluded that supplementation with purple grape juice shows an ergogenic effect in recreational runners by promoting increased time to exhaustion, accompanied by increased antioxidant activity and a possible reduction in inflammatory markers.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author