Evaluation of the Prevalence of Hepatitis B and C in Patients with Lymphoma

Aim:Hepatitis enfection reactivation during chemotherapy is a major problem in lymphoma patients. We aimed to investigate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) in lymphoma patients treated in our center.Materials and Methods:The files of non-hodgkin lymphoma (NHL) and hodgkin lymphoma (HL) patients treated in our center between 2011-2018 were retrospectively reviewed. HBsAg, Anti-HBs, Anti-HBc and Anti-HCV parameters of the patients were evaluated.Results:In 21 (8.7%) of the 240 NHL patients, HBsAg antigen was positive. Anti-HCV positivity was detected in 9 patients (3.7%). In 79 (33%) patients, HBsAg (-), Anti-HBs (+) and Anti-HBc (+) were detected and evaluated as previous hepatitis B infection. In 10 (9.1%) of the 110 HL patients, HBsAg was positive and Anti-HCV positivity was detected in 3 patients (2.7%). In 29 (26.4%) patients, HBsAg (-), Anti-HBs (+) and Anti-HBc (+) were detected and evaluated as previous hepatitis B infection. When HBsAg and Anti-HCV positivity rates were compared between NHL and HL patient groups, no statistically significant difference was detected (p values were 0.9 and 0.63, respectively).Conclusion:According to the data of our country higher positivity of HBV and HCV was determined in lymphoma patients. Hepatitis B and C positivity in our region poses an important problem. Necessary information about vaccination and prevention methods should be provided

Prospective Investigation of Factors Determining Prognosis with Oncology Patients in Intensive Care Unit of Cukurova University.

TEZ10485Tez (Uzmanlık) -- Çukurova Üniversitesi, Adana, 2014.Kaynakça (s. 52-66) var.ix, 67 s. : res. (bzs. rnk.), tablo ; 29 cm.Amaç: Çalışmanın amacı yoğun bakım ünitesinde takip edilen onkoloji hastalarının mortalitesine etki eden faktörlerin belirlenmesidir. Gereç ve yöntem: Bu çalışmada 2012-2014 yılları arasında Çukurova Üniversitesi Tıp Fakültesi İç Hastalıkları A.D. yoğun bakım ünitesinde takip edilen ardışık 100 hasta prospektif olarak incelenmiştir. Mortaliteyi etkileyen faktörleri saptamak için APACHE II, SOFA 1. gün ve SOFA 3. gün skorları kullanılmıştır. 0., 1. 2. ve 3. gün laktat düzeyleri, magnezyum, fosfor, potasyum, BUN ve beta 2 mikroglobülin düzeyleri belirlenmiştir. Hastaların yoğun bakımda takip edildiği süre boyunca vazopressör, renal, solunumsal destek ihtiyacı, nötropeni ve enfeksiyöz etkenler ile mortalite arasındaki ilişki belirlenmiştir. Yoğun bakım takibinden çıkarılıp servise devredilen hastalar (Grup 1: 40 hasta) ve yoğun bakım takibinde ölen hastalar (Grup 2: 60 hasta) olmak üzere iki grupta incelenmiştir. Verilerin değerlendirilmesinde SPSS 17.0 (SPSS Inc. Chicago, Ill, USA) paket programı kullanıldı. Bulgular: Grup 1 ve Grup 2 ‘deki hastaların APACHE II değeri (p<0,001), SOFA 1. Gün ve SOFA 3. Gün skoru (p<0,001), Prediktif mortalite oranı (p<0,001), yoğun bakıma kabul anındaki laktat değerleri (p<0,001), vazopressör destek ihtiyacı, solunumsal destek ihtiyacı, (p<0,001), renal destek ihtiyacı (p<0,05), BUN düzeyi (p<0,05), K düzeyi (p<0,05), Mg düzeyi (p<0,05) ve Acinetobacter baumannii üremesi (p<0,05) ile hastaların yoğun bakım takiplerinde exitus olması arasında istatistiksel olarak anlamlı bulunmuştur. Ayrıca hastaların izlemi sırasında yeni yoğun bakım ünitesinde izlenen hastalarda mortalite daha az bulunmuştur. Sonuç: Çalışmada incelenen parametreler dikkate alındığında hastaların uzun dönem mortalitesi ve yoğun bakım mortalitesini belirleyebilmek amacıyla tek bir parametreden ziyade birden fazla parametreyi kapsayan yeni skorlama sistemlerine ihtiyaç vardır. Yoğun bakım ünitelerinin hastaların enfeksiyon riskini azaltmak ve mortalitenin düşürülmesi amacıyla yapılması gereken ilk adımın hastalar arasındaki kontaminasyonu önleyecek şekilde sağlık personelinin eğitimi ve hastaların ayrı odalarda takibin yapılması mortaliteyi anlamlı şekilde düşürmüştür.Purpose: The aim of this study is to determine the factors that influence mortality the oncology patients in intensive care. Materials and Methods: In this study 100 patients who were followed up between 2012-2014 in the intensive care unit of Cukurova University Faculty of Medicine, Internal Medicine, were prospectively investigated. The mortality rates were evaluated by various scoring systems such as APACHE II , SOFA , SAPS throughout the duration of hospitalization we used ,first ,second and third day lactate levels , serum magnesium , phosphorus , potassium , BUN and admission beta-2-microglobulin levels. Requirements of vasopressor,renal,ventilator support during intensive care follow up, neutropenic status and infectious agents are evaluated in order to aim to mortality while follow up. Patients were divided into two groups; group 1 included 40 patients that were transferred from intensive care unit to service and group 2 included 60 patients resulted exitus during intensive care follow up SPSS program 17th version (SPSS Inc. Chicago, Ill, USA) was used to evaluate the data. Findings: Group 1 and Group 2 patients on the score of the APACHE II scores (p <0.001), SOFA 1 3 days and SOFA Day score (p <0.001), predictive mortality rate (p <0.001), intensive care admission lactate values (p <0.001), vasopressor support needs and respiratory support needs (p <0.001), renal support needs (p <0.05), BUN levels (p <0.05), C levels (p <0.05), Mg level (p <0.05), positive Acinetobacter baumannii culture (p <0.05) mean was statistically significant with mortality of patients during intensive care follow up Besides , during follow up we determined the mortality rate of the new intensive care unit was less than before. Results: Considering all parameters to determine the long term mortality and intensive care mortality, new scoring systems are needed rather than single parameters. According to physical conditions in intensive care, first step should be education of healthcare personnel for avoiding the contamination between patients and renewal of patient rooms as separate in order to reduce the infection risk and mortality rates.These cautions decreased the mortality significantly

Myeloid Neoplasia and Lymphoblastic Lymphoma with Eosinophilia After Radioactive Iodine: A Case Report

Background: Thyroid cancer is the most common endocrine cancer, with an increasing incidence around the world in the last three decades. The increased risk of secondary cancer is associated with a genetic predisposition or radioactive iodine used in the treatment. Case Report: A 65-year old male patient was operated on for thyroid papillary cancer. He received radioactive iodine on two occasions postoperatively. After six years, he presented with malaise and fatigue with leukocytosis and eosinophlilia. The physical examination revealed inguinal lymphadenopathies and splenomegaly, after examining the bone marrow and lymph node biopsies, he was diagnosed with eosinophilic myeloproliferative neoplasia and T-cell lymphoblastic leukaemia/lymphoma. Conclusion: Leukaemia and other haematological malignencies may develop after radioactive iodine treatment. Patients with radioactive iodine ablation history should be monitored for a long time

Myeloid Neoplasia and Lymphoblastic Lymphoma with Eosinophilia After Radioactive Iodine: A Case Report

Background: Thyroid cancer is the most common endocrine cancer, with an increasing incidence around the world in the last three decades. The increased risk of secondary cancer is associated with a genetic predisposition or radioactive iodine used in the treatment. Case Report: A 65-year old male patient was operated on for thyroid papillary cancer. He received radioactive iodine on two occasions postoperatively. After six years, he presented with malaise and fatigue with leukocytosis and eosinophlilia. The physical examination revealed inguinal lymphadenopathies and splenomegaly, after examining the bone marrow and lymph node biopsies, he was diagnosed with eosinophilic myeloproliferative neoplasia and T-cell lymphoblastic leukaemia/lymphoma. Conclusion: Leukaemia and other haematological malignencies may develop after radioactive iodine treatment. Patients with radioactive iodine ablation history should be monitored for a long time.Background: Thyroid cancer is the most common endocrine cancer, with an increasing incidence around the world in the last three decades. The increased risk of secondary cancer is associated with a genetic predisposition or radioactive iodine used in the treatment. Case Report: A 65-year old male patient was operated on for thyroid papillary cancer. He received radioactive iodine on two occasions postoperatively. After six years, he presented with malaise and fatigue with leukocytosis and eosinophlilia. The physical examination revealed inguinal lymphadenopathies and splenomegaly, after examining the bone marrow and lymph node biopsies, he was diagnosed with eosinophilic myeloproliferative neoplasia and T-cell lymphoblastic leukaemia/lymphoma. Conclusion: Leukaemia and other haematological malignencies may develop after radioactive iodine treatment. Patients with radioactive iodine ablation history should be monitored for a long time