The Grizzly, September 29, 1978

Social changes open Fall term • Student Deans reorganized • Rebuck stresses individuality • News in brief: Lindback award presented to profs; Student dies suddenly; Miller heads Advance Ursinus; Women\u27s council meets; Fields speaks at VPI; Nine faculty appointed; Music director honored; New Alumni Secretary named • Ursinus middle class • Dr. Snyder, interim Dean • Letters to the editor: Damage policy questioned • Life on these American campuses • I. F. picnic: Let\u27s do it again • Good bands are available: Price shouldn\u27t be primary concern • Keith Moon: The life and death of The Who? • Richter welcomes frosh • USGA reports • Danforth fellowships offered • Portrait of the professor: Dr. Roger P. Staiger • Harriers open season • Football: Tough start • Sports profile: Dave Kennedy • Cross country looks strong • Football: Pre-season peek • Field hockeyhttps://digitalcommons.ursinus.edu/grizzlynews/1000/thumbnail.jp

The Grizzly, October 20, 1978

Homecoming \u2778 Promises Color, Excitement • Judiciary Board Convicts Two • Shopping Center to Expand • On Personal Expression • Is Pledging All Fun and Games? • Ursinus\u27 Financial Aid Structure • SFARC Repairs Damage Policy • Gallagher Explores Amish • Springsteen & Dylan: Poet Laureates or Veritable Zeros? • The World\u27s Largest Hamburger • Paradise Lost: College Woods Gone Junkyard? • X-C: Dual Wins • Bears Fall Prey Again • Soccer Wins Five • News in Brief: Our New Look; Remember to Vote; Yom Kippur Celebration; Ursinus Announces Business Workshop; Library News Shortshttps://digitalcommons.ursinus.edu/grizzlynews/1003/thumbnail.jp

A Highly Stable Blood Meal Alternative for Rearing \u3cem\u3eAedes\u3c/em\u3e and \u3cem\u3eAnopheles\u3c/em\u3e Mosquitoes

We investigated alternatives to whole blood for blood feeding of mosquitoes with a focus on improved stability and compatibility with mass rearing programs. In contrast to whole blood, an artificial blood diet of ATP-supplemented plasma was effective in maintaining mosquito populations and was compatible with storage for extended periods refrigerated, frozen, and as a lyophilized powder. The plasma ATP diet supported rearing of both Anopheles and Aedes mosquitoes. It was also effective in rearing Wolbachia-infected Aedes mosquitoes, suggesting compatibility with vector control efforts

Return to Fort Rock Cave: Assessing the Site\u27s Potential to Contribute to Ongoing Debates about how and when Humans Colonized the Great Basin

Oregon’s Fort Rock Cave is iconic in respect to both the archaeology of the northern Great Basin and the history of debate about when the Great Basin was colonized. In 1938, Luther Cressman recovered dozens of sagebrush bark sandals from beneath Mt. Mazama ash that were later radiocarbon dated to between 10,500 and 9350 cal B.P. In 1970, Stephen Bedwell reported finding lithic tools associated with a date of more than 15,000 cal B.P., a date dismissed as unreasonably old by most researchers. Now, with evidence of a nearly 15,000-year-old occupation at the nearby Paisley Five Mile Point Caves, we returned to Fort Rock Cave to evaluate the validity of Bedwell’s claim, assess the stratigraphic integrity of remaining deposits, and determine the potential for future work at the site. Here, we report the results of additional fieldwork at Fort Rock Cave undertaken in 2015 and 2016, which supports the early Holocene occupation, but does not confirm a pre–10,500 cal B.P. human presence

Spatio-temporal distribution of Spiroplasma infections in the tsetse fly (Glossina fuscipes fuscipes) in northern Uganda

Copyright: © 2019 Schneider et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Tsetse flies (Glossina spp.) are vectors of parasitic trypanosomes, which cause human (HAT) and animal African trypanosomiasis (AAT) in sub-Saharan Africa. In Uganda, Glossina fuscipes fuscipes (Gff) is the main vector of HAT, where it transmits Gambiense disease in the northwest and Rhodesiense disease in central, southeast and western regions. Endosymbionts can influence transmission efficiency of parasites through their insect vectors via conferring a protective effect against the parasite. It is known that the bacterium Spiroplasma is capable of protecting its Drosophila host from infection with a parasitic nematode. This endosymbiont can also impact its host\u27s population structure via altering host reproductive traits. Here, we used field collections across 26 different Gff sampling sites in northern and western Uganda to investigate the association of Spiroplasma with geographic origin, seasonal conditions, Gff genetic background and sex, and trypanosome infection status. We also investigated the influence of Spiroplasma on Gff vector competence to trypanosome infections under laboratory conditions. Generalized linear models (GLM) showed that Spiroplasma probability was correlated with the geographic origin of Gff host and with the season of collection, with higher prevalence found in flies within the Albert Nile (0.42 vs 0.16) and Achwa River (0.36 vs 0.08) watersheds and with higher prevalence detected in flies collected in the intermediate than wet season. In contrast, there was no significant correlation of Spiroplasma prevalence with Gff host genetic background or sex once geographic origin was accounted for in generalized linear models. Additionally, we found a potential negative correlation of Spiroplasma with trypanosome infection, with only 2% of Spiroplasma infected flies harboring trypanosome co-infections. We also found that in a laboratory line of Gff, parasitic trypanosomes are less likely to colonize the midgut in individuals that harbor Spiroplasma infection. These results indicate that Spiroplasma infections in tsetse may be maintained by not only maternal but also via horizontal transmission routes, and Spiroplasma infections may also have important effects on trypanosome transmission efficiency of the host tsetse. Potential functional effects of Spiroplasma infection in Gff could have impacts on vector control approaches to reduce trypanosome infections

The Grizzly, December 1, 1978

Task Force Reviews Health Services; Bookstore Also Discussed • New Curriculum Approved • SAC Discusses New Frat & Allocations • Biology Department Alters Curriculum • A Good Editorial • Let\u27s See Co-Ed Dorms • A Mutually Advantageous Symbiosis • Letters to the Editor: Sleeping Awareness; Disturbing Guyana Attitudes • Portrait of the Professor: Dr. Patrick J. Mulvanny • Parking: Problem At Ursinus • If Zacharias Could See Us Now... • Think Snow • The Rocky Horror Show: A Celluloid Wasteland • Audio Corner: Loudspeakers • Thompson-Gay Soon To Be Theater • Logic & Dance • Drinking Myths • Hopes High For Hoops • Football Ends On Good Note • Ursinus Girls Drown Dickinson • Marathon Men Compete • Bears Net .500 Against Florida Foes • First Winter Weather Day ; Stimeling Exhibit To Be Presentedhttps://digitalcommons.ursinus.edu/grizzlynews/1008/thumbnail.jp

Investigating the Potential and Pitfalls of EV-Encapsulated MicroRNAs as Circulating Biomarkers of Breast Cancer

Extracellular vesicles (EVs) shuttle microRNA (miRNA) throughout the circulation and are believed to represent a fingerprint of the releasing cell. We isolated and characterized serum EVs of breast tumour-bearing animals, breast cancer (BC) patients, and healthy controls. EVs were characterized using transmission electron microscopy (TEM), protein quantification, western blotting, and nanoparticle tracking analysis (NTA). Absolute quantitative (AQ)-PCR was employed to analyse EV-miR-451a expression. Isolated EVs had the appropriate morphology and size. Patient sera contained significantly more EVs than did healthy controls. In tumour-bearing animals, a correlation between serum EV number and tumour burden was observed. There was no significant relationship between EV protein yield and EV quantity determined by NTA, highlighting the requirement for direct quantification. Using AQ-PCR to relate miRNA copy number to EV yield, a significant increase in miRNA-451a copies/EV was detected in BC patient sera, suggesting potential as a novel biomarker of breast cancer

The Grizzly, September 19, 1980

Reagan, Anderson Leading Carter In Campus Poll • Wismer Lunch Off to Optimistic Start • Explosive Bomb Found At NMD • College Van Policy Drastically Revised • Campus Expands With Enrollment • Bad Conditions Haunt New Women\u27s Dorm • Kane Appointed As New Executive Assistant • Ursinus Still Packing Them In • Ursinus News In Brief: Myrin Hosts Davison Exhibit; Davies Promoted In Admissions • TG Annex Almost Complete • Evening School Expands Services • Freshmen Class & USGA Treasurer Elections Coming Soon • Ron Baltz and Jenny Perform • Ritter Center To Open October 4 • For The Musically Inclined • WRUC - On The Air? • Yes A Maybe • Alternatives To Typical Parties • The Rush Is On • Switchboard Under New Operation • Police Rally To Cut Down Thefts • 1978 Alumnus Selected To Receive Award • Freshmen Offer Good Stats And Great Figures • Pre-Medical Evaluation Committee Reorganized • Bomberger Tower Finally To Be Replaced • Booters Sloppy in Close Call Over Drew • Delta Pi, ZX Defend Title; Intramural Football Underway • MAC Title: Cross Country Goal • Lack of Offense Hurts in Loss to Alfred • Hockey Starts Strong at Penn State Tourneyhttps://digitalcommons.ursinus.edu/grizzlynews/1040/thumbnail.jp

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead