Gaining Insight into Transition and Progression of Students on the Autism Spectrum - DISCOVER a Transition Programme with a Difference

Autism is a neurodevelopment condition that is ‘characterised by qualitative impairments in social communication and social interaction across contexts and a repetitive or restricted pattern of interest, behaviour and activity’ (Lambe, 2019:1531). According to the autistic rights movement, ‘autistic people are not disconnected from the world around them, they are differently connected to it’ (Leveto, 2018 :3). Over the last number of years, there has been a move away from defining autism as a ‘disorder’ and towards redefining it as a ‘difference’ (Ring et al, 2018). In this paper, the terms ‘autism’ or ‘on the spectrum’ will be used. The Moving to Further and Higher Education Report (Guckin et al, 2013) recommended the development of targeted access initiatives to support the academic and social needs of students with a disability in transition and progressing through further education. Targeted orientation programmes are used to allow students from under-represented groups to meet other students, visit the campus, tour the library and get essential information that will support the student’s transition to higher education. Disability Support Services (DSS) are keenly aware of the importance of the transition from second-level education into third level education. Year on year there is an increase in the number of students with disabilities who are accessing third-level education. Students with disabilities now make up approximately 6.2% of the total student population (AHEAD, 2019). Since 2016, there has been a 25% increase in the number of students accessing higher education who are on the spectrum

Internet Use by Older Adults with Bipolar Disorder: International Survey Results

Background: The world population is aging and the number of older adults with bipolar disorder is increasing. Digital technologies are viewed as a framework to improve care of older adults with bipolar disorder. This analysis quantifies Internet use by older adults with bipolar disorder as part of a larger survey project about information seeking. Methods: A paper-based survey about information seeking by patients with bipolar disorder was developed and translated into 12 languages. The survey was anonymous and completed between March 2014 and January 2016 by 1222 patients in 17 countries. All patients were diagnosed by a psychiatrist. General estimating equations were used to account for correlated data. Results: Overall, 47% of older adults (age 60 years or older) used the Internet versus 87% of younger adults (less than 60 years). More education and having symptoms that interfered with regular activities increased the odds of using the Internet, while being age 60 years or older decreased the odds. Data from 187 older adults and 1021 younger adults were included in the analysis excluding missing values. Conclusions: Older adults with bipolar disorder use the Internet much less frequently than younger adults. Many older adults do not use the Internet, and technology tools are suitable for some but not all older adults. As more health services are only available online, and more digital tools are developed, there is concern about growing health disparities based on age. Mental health experts should participate in determining the appropriate role for digital tools for older adults with bipolar disorder

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

A year of engaging with the discipline of noticing: five mathematics lecturers\u27 reflections

In September 2010, five mathematics lecturers set out on a professional development project with the following aim: to reflect on teaching practice using John Mason\u27s Discipline of Noticing. At the end of the academic year, each lecturer considered her experiences of engaging with the process. In this paper, we describe the observations made and discuss the benefits and challenges of engaging with the Discipline of Noticing, namely, the benefits of a collaborative approach; the challenges of noticing in the moment\u27 and the advantages of and difficulties with, writing brief-but-vivid accounts

Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer\u27s disease.

We performed an affected sib-pair (ASP) linkage analysis to test for the effects of age at onset (AAO), rate of decline (ROD), and Apolipoprotein E (APOE) genotype on linkage to late-onset Alzheimer\u27s disease (AD) in a sample comprising 428 sib-pairs. We observed linkage of mean AAO to chromosome 21 in the whole sample (max LOD = 2.57). This came entirely from the NIMH sample (max LOD = 3.62), and was strongest in pairs with high mean AAO (\u3e80). A similar effect was observed on chromosome 2q in the NIMH sample (max LOD = 2.73); this region was not typed in the IADC/UK sample. Suggestive evidence was observed in the combined sample of linkage of AAO difference to chromosome 19q (max LOD = 2.33) in the vicinity of APOE and 12p (max LOD = 2.22), with linkage strongest in sib-pairs with similar AAO. Mean ROD showed suggestive evidence of linkage to chromosome 9q in the whole sample (max LOD = 2.29), with the effect strongest in the NIMH sample (max LOD = 3.58), and in pairs with high mean ROD. Additional suggestive evidence was also observed in the NIMH sample with AAO difference on chromosome 6p (max LOD = 2.44) and 15p (max LOD = 1.87), with linkage strongest in pairs with similar AAO, and in the UK sample with mean ROD on chromosome 1p (max LOD = 2.73, linkage strongest in pairs with high mean ROD). We also observed suggestive evidence of increased identical by descent (IBD) in APOE epsilon4 homozygotes on chromosome 1 (max LOD = 3.08) and chromosome 9 (max LOD = 3.34). The previously reported genome-wide linkage of AD to chromosome 10 was not influenced by any of the covariates studied

Author Correction: Genetic meta-analysis of diagnosed Alzheimer\u27s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

An amendment to this paper has been published and can be accessed via a link at the top of the paper