19 research outputs found
Effective Teaching and Learning in Higher Education: a United Kingdom Perspective
This paper explores the current teaching and learning environment in higher education in the UK, concentrating on England. We ask: Is there a positive and supportive environment for learning and teaching in the UK? The conceptual and theoretical foundations underpinning practice in higher education teaching and learning are examined as is the support and impetus provided by government and policy. The nature of academic identities and the structure and engagement in academic development is also assessed. We pose a series of important questions within this paper, of significance to the Irish Higher Education sector
Effectively Including Human Factors in the Design of New Facilities
Human error is a major cause of incidents in the offshore industry. For example, in the Gulf of Mexico region in 1998, 38% of all incidents were attributed to human error with an additional 9% of incidents resulting from slips, trips, and falls (MMS 2000-021, OCS Report). Human Factors, when integrated during the design of a new offshore facility, can reduce the potential for human error and the occurrence of unfortunate incidents.
Quite often the implementation of Human Factors (HF) during design is disregarded because of the notion that it will add unacceptable costs. Review of the cost/benefit data contained in this paper proves that notion to be untrue. Although cost/benefit is important, it was not the primary focus of this Working Group. This paper鈥檚 focus is to develop a means or a strategy to effectively integrate the application of HF design principles into all phases of a new capital design project.
This Working Group鈥檚 objective during the Second International Workshop on Human Factors in Offshore Operations was to generate discussion concerning HF integration strategies and to focus on specific implementation issues that have been shown to be successful. These include but are not limited to:
路 The factors critical to the success of HF integration
路 What HF activities should be conducted
路 At what stage during the various design phases should HF activities take place
路 HF strategies, how to decide what level of human factors engineering is required
路 The qualifications and responsibilities of those executing HF activitie
Effectively Including Human Factors in the Design of New Facilities
Human error is a major cause of incidents in the offshore industry. For example, in the Gulf of Mexico region in 1998, 38% of all incidents were attributed to human error with an additional 9% of incidents resulting from slips, trips, and falls (MMS 2000-021, OCS Report). Human Factors, when integrated during the design of a new offshore facility, can reduce the potential for human error and the occurrence of unfortunate incidents.
Quite often the implementation of Human Factors (HF) during design is disregarded because of the notion that it will add unacceptable costs. Review of the cost/benefit data contained in this paper proves that notion to be untrue. Although cost/benefit is important, it was not the primary focus of this Working Group. This paper鈥檚 focus is to develop a means or a strategy to effectively integrate the application of HF design principles into all phases of a new capital design project.
This Working Group鈥檚 objective during the Second International Workshop on Human Factors in Offshore Operations was to generate discussion concerning HF integration strategies and to focus on specific implementation issues that have been shown to be successful. These include but are not limited to:
路 The factors critical to the success of HF integration
路 What HF activities should be conducted
路 At what stage during the various design phases should HF activities take place
路 HF strategies, how to decide what level of human factors engineering is required
路 The qualifications and responsibilities of those executing HF activitie
Science AMA Series: Antarctic Peninsula Paleontology Project
Transcript of an online colloquium between members of the APPP expedition and readers of the online bulletin board Reddit
The Iowa Homemaker vol.21, no.9
Keeping Up With Today, Marilyn Clayton, page 2
Need for Homemaking Education, Lois Stewart, page 3
Uniforms Alter Campus Co-Etiquette, Joan Miller, page 5
Keynotes Furnishings, Interview, Misses Fisher, O鈥橞ryan, page 6
For a Vacation With Pay, Pat O鈥機onnell, page 8
A Graduate Describes Food Publicity, Winnifred Cannon, page 9
Shipyards Sponsor Child Care Centers, Jeanne O鈥機onnor, page 10
Silhouette for Spring, Ruth Midgorden, page 11
What鈥檚 New in Home Economics, Mildred Krogh, page 12
Iowa State Promotes Gardens for Victory, Jo Ann Reeves, page 14
Do You Manage Your Time Efficiently?, Marian Loofe, page 15
Dietitians to the Front, Lorraine Berger, page 16
Across Alumnae Desks, Harriet Keen, page 18
Notions Corner, page 20
Efficiency in Food Preparation, Norma Dale, page 21
Alums in the News, Patricia Maddex, page 2
Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer
Fatty acid synthase (FASN) and ATP-citrate lyase, key enzymes of de novo lipogenesis, are significantly upregulated and activated in many cancers and portend poor prognosis. Even though the role of lipogenesis in providing proliferative and survival advantages to cancer cells has been described, the impact of aberrant activation of lipogenic enzymes on cancer progression remains unknown. In this study, we found that elevated expression of FASN is associated with advanced stages of colorectal cancer (CRC) and liver metastasis, suggesting that it may play a role in progression of CRC to metastatic disease. Targeted inhibition of lipogenic enzymes abolished expression of CD44, a transmembrane protein associated with metastases in several cancers including CRC. In addition, inhibition of lipogenic enzymes and reduced expression of CD44 attenuated the activation of MET, Akt, FAK, and paxillin, which are known to regulate adhesion, migration, and invasion. These changes were consistent with an observed decrease in migration and adhesion of CRC cells in functional assays and with reorganization of actin cytoskeleton upon FASN inhibition. Despite the modest effect of FASN inhibition on tumor growth in xenografts, attenuation of lipogenesis completely abolished establishment of hepatic metastasis and formation of secondary metastasis. Together, our findings suggest that targeting de novo lipogenesis may be a potential treatment strategy for advanced CRC
Recommended from our members
1961
My Ideal Course, Underwater, U.S.A. (page 1) From the Editor (3) Turf Management Club News (3) Quotes from 1961 Seniors (4) The United States Most Western Owned Golf Course: Armed Forces Golf Course, Guam (5) Turf Majors Participate in Horticultural Show (7) Picture - G.C.S.A Scholarships Awarded to Three Turf Seniors (8) Picture - Stockbridge - Majors in turf Management (9) Opportunity and Education (10) The Most Outstanding Turf Senior for the Year - 1961 (11) How We Prepare Our Greens Before Topdressing (12) An Inexpensive Cure for Weeds and Poa Annua (13) Watering (14) Picture - Honorary Members of the Turf Management Club (16) Picture - Graduates of Winter School for Turf Managers - 1961 (17) Welcome Speech by Narry Sperandio (A-1) Handle with Care by Dr. Ellsworth H. Wheeler (A-2) Current Ideas on Green Construction - Panel Discussion (A-4) Automatic Systems for Watering by Robert F. Harper (A-14) History of Golf Course Architecture by Geoffrey S. Cornish (A-22) Effect of Nutrition on Turf Diseases by Dr. Houston B. Couch Turf Disease Control and Use of Fungicides by Dr. R. J. Lukens Trees and Tree Care by Gordon S. King (A-38) Arsenical Toxicity by Dr. C. R. Skogley (A-41) Soil Reaction to Arsenical Compounds by Joseph E. Steckel Brush Control For the Golf Course by Dr. William I. Boyd (A-51) Massachusetts Highway Herbicide Program by Joseph L. Beasley (A-54) General Turf (Alternate Session): Observations on Highway Turf Establishment & Maintenance by E.F. Button (A-62) Pre-emerge Chemicals for the Control of Crabgrass by Dr. John R. Havis, John M. Zak & Joseph Troll (A-70) Root Growth of Turf Grasses as Affected by Different heights of Cut and Nutrient Levels by Evangel J. Bredakis (A-71) The Use of Sod by Daniel Pellegrino (A-72
Primary Care and Youth Mental Health in Ireland: Qualitative Study in Deprived Urban Areas
BACKGROUND: Mental disorders account for six of the 20 leading causes of disability worldwide with a very high prevalence of psychiatric morbidity in youth aged 15-24 years. However, healthcare professionals are faced with many challenges in the identification and treatment of mental and substance use disorders in young people (e.g. young people\u27s unwillingness to seek help from healthcare professionals, lack of training, limited resources etc.) The challenge of youth mental health for primary care is especially evident in urban deprived areas, where rates of and risk factors for mental health problems are especially common. There is an emerging consensus that primary care is well placed to address mental and substance use disorders in young people especially in deprived urban areas. This study aims to describe healthcare professionals\u27 experience and attitudes towards screening and early intervention for mental and substance use disorders among young people (16-25 years) in primary care in deprived urban settings in Ireland. METHODS: The chosen method for this qualitative study was inductive thematic analysis which involved semi-structured interviews with 37 healthcare professionals from primary care, secondary care and community agencies at two deprived urban centres. RESULTS: We identified three themes in respect of interventions to increase screening and treatment: (1) Identification is optimised by a range of strategies, including raising awareness, training, more systematic and formalised assessment, and youth-friendly practices (e.g. communication skills, ensuring confidentiality); (2) Treatment is enhanced by closer inter-agency collaboration and training for all healthcare professionals working in primary care; (3) Ongoing engagement is enhanced by motivational work with young people, setting achievable treatment goals, supporting transition between child and adult mental health services and recognising primary care\u27s longitudinal nature as a key asset in promoting treatment engagement. CONCLUSIONS: Especially in deprived areas, primary care is central to early intervention for youth mental health. Identification, treatment and continuing engagement are likely to be enhanced by a range of strategies with young people, healthcare professionals and systems. Further research on youth mental health and primary care, including qualitative accounts of young people\u27s experience and developing complex interventions that promote early intervention are priorities
Gendered structures in action: \u27male\u27 versus \u27female\u27 agendas in a family rights project
This article describes the formation of a family rights project in
Limerick. It explains how the project came to focus on a rather
narrow legalistic definition of parental rights, typified as a \u27male
agenda\u27. It explores the implications of this agenda for the
attraction of parents to the project. Finally and more broadly, it
raises questions about the relevance of partnership activities
between statutory and community agencies, given the gendered
nature of organisations (Acker, 1990) and the likely dominance of
what is referred to as the \u27male agenda\u27. The paper draws on
documentary material concerning the establishment of the group,
together with group evaluation material and qualitative data from
individual semi-structured interviews with all the members of
what came to be referred to as the Core Group in the family rights
projec
Tourism and development in Ballyhoura: women\u27s business?
Tourism and other kinds of local development have become important elements, in
generating employment in rural Ireland. Yet, despite a commitment to local participation and to
gender auditing, women are typically under-represented in structures promoting tourism\u27 and
other kinds of development at local level (Kearney, et al., 1995). Using documentary evidence,
this paper first describes this phenomenon in one particular area (viz., Ballyhoura), Second,
drawing on O\u27Connell\u27s (1987) work, it suggests that this pattern reflects the subtle nature and
limits of patriarchal control. Third, drawing on interview material with a sample of women who
were individual shareholders in the Ballyhoura Failte Co-operative, it suggests that this control
involves the selective obscuring of gender in particular contexts, and the selective discounting of
the structural realities of power and money. Finally, the article highlights those factors which
play a part in modifying some of the consequences, but not the consensual reality, of such control