2,180 research outputs found

    The shifting identities of French popular cinema

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    _France on Film: Reflections on Popular French Cinema_ Edited by Lucy Mazdon London: Wallflower Press, 2001 ISBN 1 903364-08-6 pbk 180 pp

    Kings Wharf and Superdudeywords

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    Exploring the shifting space between handwriting, calligraphy and Graffiti

    Dissecting complex traits: recent advances in hypertension genomics

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    Genome-wide association scans are beginning to identify risk alleles for a number of complex diseases and traits. Essential hypertension looked as though it would be an exception to this trend after the Wellcome Trust Case Control Consortium data were published in 2007. However, more recent scans and meta-analyses have reversed the fortunes of essential hypertension. A number of loci have been identified, including a new antihypertensive drug target in the guise of the serine/threonine kinase SPAK. This kinase forms part of a novel kinase cascade that regulates the NCCT (Na+/Cl- co-transporter; SLC12A3) in the kidney and is defective in a rare Mendelian hypertension syndrome (Gordon's syndrome). Genome-wide scans are also being used to look for alleles to predict individual response to antihypertensive drugs and their risk of causing side-effects. The results of these are expected in the near future and may finally deliver the long-awaited goal of personalized drug therapy for hypertensive patients

    A more effective coordinate system for parameter estimation of precessing compact binaries from gravitational waves

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    Ground-based gravitational wave detectors are sensitive to a narrow range of frequencies, effectively taking a snapshot of merging compact-object binary dynamics just before merger. We demonstrate that by adopting analysis parameters that naturally characterize this 'picture', the physical parameters of the system can be extracted more efficiently from the gravitational wave data, and interpreted more easily. We assess the performance of MCMC parameter estimation in this physically intuitive coordinate system, defined by (a) a frame anchored on the binary's spins and orbital angular momentum and (b) a time at which the detectors are most sensitive to the binary's gravitational wave emission. Using anticipated noise curves for the advanced-generation LIGO and Virgo gravitational wave detectors, we find that this careful choice of reference frame and reference time significantly improves parameter estimation efficiency for BNS, NS-BH, and BBH signals.Comment: 11 pages, 5 figures, submitted to Phys. Rev.
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