Seasonality and Other Components of the Irish Unemployment Series. Quarterly Economic Commentary, April 1980

This paper examines methods of seasonally adjusting economic time series; in particular, it examines the methods of estimating the seasonal and other time series components of unemployment in Ireland. Thus, while the results of this analysis may have implications for other time series, the study's main aim is the adjustment of the unemployment data. It should be emphasised that a univariate analysis is being carried out here and the optimal method of seasonal adjustment could be much different in the case of a multivariate approach - Wallis (1976). The results shed some light on the question of whether the series contains an additive multiplicative or mixed seasonal element - Dowling (1975) and Bradley (1977). It also agrees with the recommendations made in the Report of the Interdepartmental Study Group on Unemployment Statistics (ISGU) (1979) that a seasonally adjusted series of Live Register figures be compiled and published. However, the most satisfactory method of seasonal adjustment leads to the rejection of another of the group's recommendations: that the frequency of publication of the present weekly Live Register statement should be reduced to a monthly basis

GravEn: Software for the simulation of gravitational wave detector network response

Physically motivated gravitational wave signals are needed in order to study the behaviour and efficacy of different data analysis methods seeking their detection. GravEn, short for Gravitational-wave Engine, is a MATLAB software package that simulates the sampled response of a gravitational wave detector to incident gravitational waves. Incident waves can be specified in a data file or chosen from among a group of pre-programmed types commonly used for establishing the detection efficiency of analysis methods used for LIGO data analysis. Every aspect of a desired signal can be specified, such as start time of the simulation (including inter-sample start times), wave amplitude, source orientation to line of sight, location of the source in the sky, etc. Supported interferometric detectors include LIGO, GEO, Virgo and TAMA.Comment: 10 Pages, 3 Figures, Presented at the 10th Gravitational Wave Data Analysis Workshop (GWDAW-10), 14-17 December 2005 at the University of Texas, Brownsvill

bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice

Helicobacter infection causes a chronic superficial gastritis that in some cases progresses via atrophic gastritis to adenocarcinoma. Proapoptotic bak has been shown to regulate radiation-induced apoptosis in the stomach and colon and also susceptibility to colorectal carcinogenesis in vivo. Therefore we investigated the gastric mucosal pathology following H. felis infection in bak-null mice at 6 or 48 wk postinfection. Primary gastric gland culture from bak-null mice was also used to assess the effects of bak deletion on IFN-γ-, TNF-α-, or IL-1β-induced apoptosis. bak-null gastric corpus glands were longer, had increased epithelial Ki-67 expression, and contained fewer parietal and enteroendocrine cells compared with the wild type (wt). In wt mice, bak was expressed at the luminal surface of gastric corpus glands, and this increased 2 wk post-H. felis infection. Apoptotic cell numbers were decreased in bak-null corpus 6 and 48 wk following infection and in primary gland cultures following cytokine administration. Increased gastric epithelial Ki-67 labeling index was observed in C57BL/6 mice after H. felis infection, whereas no such increase was detected in bak-null mice. More severe gastric atrophy was observed in bak-null compared with C57BL/6 mice 6 and 48 wk postinfection, and 76% of bak-null compared with 25% of C57BL/6 mice showed evidence of gastric dysplasia following long-term infection. Collectively, bak therefore regulates gastric epithelial cell apoptosis, proliferation, differentiation, mucosal thickness, and susceptibility to gastric atrophy and dysplasia following H. felis infection

In vivo cranial bone strain and bite force in the agamid lizard Uromastyx geyri

In vivo bone strain data are the most direct evidence of deformation and strain regimes in the vertebrate cranium during feeding and can provide important insights into skull morphology. Strain data have been collected during feeding across a wide range of mammals; in contrast, in vivo cranial bone strain data have been collected from few sauropsid taxa. Here we present bone strain data recorded from the jugal of the herbivorous agamid lizard Uromastyx geyri along with simultaneously recorded bite force. Principal and shear strain magnitudes in Uromastyx geyri were lower than cranial bone strains recorded in Alligator mississippiensis, but higher than those reported from herbivorous mammals. Our results suggest that variations in principal strain orientations in the facial skeleton are largely due to differences in feeding behavior and bite location, whereas food type has little impact on strain orientations. Furthermore, mean principal strain orientations differ between male and female Uromastyx during feeding, potentially because of sexual dimorphism in skull morphology