Toward the total synthesis of spirastrellolide A. Part 3: Intelligence gathering and preparation of a ring-expanded analogue

Different methods for the formation of the C.25–C.26 bond of spirastrellolide A (1) are evaluated that might qualify for the end game of the projected total synthesis, with emphasis on metathetic ways to forge the macrocyclic frame

The dependence of HII region properties on global and local surface brightness within galaxy discs

Using B, R, and H-alpha images of roughly equal-sized samples of low surface brightness (LSB) and high surface brightness (HSB) galaxies (~40 galaxies apiece), we have explored the dependence of HII region properties on local and global disc surface brightness. We have done this by constructing co-added HII region luminosity functions (LFs) according to local and central disc surface brightness and fitting Schechter functions to these LFs. The results show that the shape of the HII region LF within LSB galaxies does not change noticeably as different limiting (i.e., mu>mu_lim) local surface brightness values are used. However, the LFs for HSB galaxies have larger values of L_* and are less steep at the faint-end than those of LSB galaxies for limiting B-band local surface brightness values as faint as mu_B,lim~23-24. Both the LFs and the data for individual HII regions show that luminous (log L>39 ergs/s) HII regions are much more common within HSB discs than within LSB discs, implying that the newly formed star clusters are also larger. Taking this into account along with the results of Monte Carlo simulations, the shapes of the LFs imply that the regions within LSB discs and those within the LSB areas of HSB discs are relatively old (~5 Myr) while the regions within HSB discs for mu_B<24 are significantly younger (<1 Myr). Since the majority of the LSB galaxies do not have noticeable spiral arms and the majority of the HSB galaxies do, this may indicate a transition within HSB discs from spiral arm-driven star formation to a more locally driven, possibly sporadic form of star formation at mu_B~24, a transition that does not appear to occur within LSB discs.Comment: Accepted to MNRA

Immediate Memory and Electrophysiologic Effects of Prefrontal Cortex Transcranial Direct Current Stimulation on Neurotypical Individuals and Individuals with Chronic Traumatic Brain Injury: A Pilot Study.

PURPOSE/AIM: Memory impairment post-TBI is common, frequently persistent, and functionally debilitating. The purposes of this pilot study were to assess and to compare immediate behavioral auditory working memory and electrophysiologic effects of three different, randomized, conditions of left dorsolateral prefrontal cortex (LDLPFC) transcranial direct current stimulation (tDCS) applied to four neurotypical adults and four adults with chronic traumatic brain injury (TBI). MATERIALS/METHODS: Pre- and post- anodal, cathodal, and sham tDCS auditory memory performance, auditory event-related potentials (P300 amplitude and latency) and power of alpha and theta EEG bands were measured across individuals in each group. RESULTS: Post-anodal tDCS only, the neurotypical and TBI groups both demonstrated significantly improved immediate auditory memory function. Also post-anodal tDCS, the TBI group demonstrated significantly increased P300 amplitude versus post-sham tDCS. The neurotypical group demonstrated no pre- post tDCS electrophysiologic changes across conditions. CONCLUSIONS: These findings are consistent with findings of other studies of immediate tDCS effects on other types of memory in neurotypical individuals and in individuals with Parkinson's disease, Alzheimer's disease, and stroke and suggest that individuals with memory impairments second to chronic TBI may benefit from LDLPFC anodal tDCS. Pairing tDCS with traditional behavioral memory interventions may facilitate TBI rehabilitation outcomes and warrants continued investigation

Response to Comment on `Undamped electrostatic plasma waves' [Phys. Plasmas 19, 092103 (2012)]

Numerical and experimental evidence is given for the occurrence of the plateau states and concomitant corner modes proposed in \cite{valentini12}. It is argued that these states provide a better description of reality for small amplitude off-dispersion disturbances than the conventional Bernstein-Greene-Kruskal or cnoidal states such as those proposed in \cite{comment

Hubble Space Telescope Planetary Camera Images of NGC 1316

We present HST Planetary Camera V and I~band images of the central region of the peculiar giant elliptical galaxy NGC 1316. The inner profile is well fit by a nonisothermal core model with a core radius of 0.41" +/- 0.02" (34 pc). At an assumed distance of 16.9 Mpc, the deprojected luminosity density reaches \sim 2.0 \times 10^3 L_{\sun} pc$^{-3}$. Outside the inner two or three arcseconds, a constant mass-to-light ratio of $\sim 2.2 \pm 0.2$ is found to fit the observed line width measurements. The line width measurements of the center indicate the existence of either a central dark object of mass 2 \times 10^9 M_{\sun}, an increase in the stellar mass-to-light ratio by at least a factor of two for the inner few arcseconds, or perhaps increasing radial orbit anisotropy towards the center. The mass-to-light ratio run in the center of NGC 1316 resembles that of many other giant ellipticals, some of which are known from other evidence to harbor central massive dark objects (MDO's). We also examine twenty globular clusters associated with NGC 1316 and report their brightnesses, colors, and limits on tidal radii. The brightest cluster has a luminosity of 9.9 \times 10^6 L_{\sun} ($M_V = -12.7$), and the faintest detectable cluster has a luminosity of 2.4 \times 10^5 L_{\sun} ($M_V = -8.6$). The globular clusters are just barely resolved, but their core radii are too small to be measured. The tidal radii in this region appear to be $\le$ 35 pc. Although this galaxy seems to have undergone a substantial merger in the recent past, young globular clusters are not detected.Comment: 21 pages, latex, postscript figures available at ftp://delphi.umd.edu/pub/outgoing/eshaya/fornax

Phase transition in the collisionless regime for wave-particle interaction

Gibbs statistical mechanics is derived for the Hamiltonian system coupling self-consistently a wave to N particles. This identifies Landau damping with a regime where a second order phase transition occurs. For nonequilibrium initial data with warm particles, a critical initial wave intensity is found: above it, thermodynamics predicts a finite wave amplitude in the limit of infinite N; below it, the equilibrium amplitude vanishes. Simulations support these predictions providing new insight on the long-time nonlinear fate of the wave due to Landau damping in plasmas.Comment: 12 pages (RevTeX), 2 figures (PostScript

Closed Timelike Curves in Relativistic Computation

In this paper, we investigate the possibility of using closed timelike curves (CTCs) in relativistic hypercomputation. We introduce a wormhole based hypercomputation scenario which is free from the common worries, such as the blueshift problem. We also discuss the physical reasonability of our scenario, and why we cannot simply ignore the possibility of the existence of spacetimes containing CTCs.Comment: 17 pages, 5 figure