Tank shipment of industrial chemicals.

Thesis (M.B.A.)--Boston Universit

Lactobacillus ruminis strains cluster according to their mammalian gut source

peer-reviewedBackground Lactobacillus ruminis is a motile Lactobacillus that is autochthonous to the human gut, and which may also be isolated from other mammals. Detailed characterization of L. ruminis has previously been restricted to strains of human and bovine origin. We therefore sought to expand our bio-bank of strains to identify and characterise isolates of porcine and equine origin by comparative genomics. Results We isolated five strains from the faeces of horses and two strains from pigs, and compared their motility, biochemistry and genetic relatedness to six human isolates and three bovine isolates including the type strain 27780T. Multilocus sequence typing analysis based on concatenated sequence data for six individual loci separated the 16 L. ruminis strains into three clades concordant with human, bovine or porcine, and equine sources. Sequencing the genomes of four additional strains of human, bovine, equine and porcine origin revealed a high level of genome synteny, independent of the source animal. Analysis of carbohydrate utilization, stress survival and technological robustness in a combined panel of sixteen L. ruminis isolates identified strains with optimal survival characteristics suitable for future investigation as candidate probiotics. Under laboratory conditions, six human isolates of L. ruminis tested were aflagellate and non-motile, whereas all 10 strains of bovine, equine and porcine origin were motile. Interestingly the equine and porcine strains were hyper-flagellated compared to bovine isolates, and this hyper-flagellate phenotype correlated with the ability to swarm on solid medium containing up to 1.8% agar. Analysis by RNA sequencing and qRT-PCR identified genes for the biosynthesis of flagella, genes for carbohydrate metabolism and genes of unknown function that were differentially expressed in swarming cells of an equine isolate of L. ruminis. Conclusions We suggest that Lactobacillus ruminis isolates have potential to be used in the functional food industry. We have also identified a MLST scheme able to distinguish between strains of L. ruminis of different origin. Genes for non-digestible oligosaccharide metabolism were identified with a putative role in swarming behaviour.This work was supported by a Principal Investigator Award (07/IN.1/B1780) from Science Foundation Ireland to P.W. O’Toole

Site multiplicity of rare earth ions in III-nitrides

This presentation reviews recent lattice location studies of RE ions in GaN by electron emission channelling (EC) and X-ray absorption fine structure (XAFS) techniques. These studies agree that RE ions at low concentrations (whether they are incorporated during growth or introduced later by ion implantation) predominantly occupy Ga substitutional sites, as expected from considerations of charge equivalence. We combine this result with some examples of the welldocumented richness of optical spectra of GaN:RE3+ to suggest that the luminescence of these materials may be ascribed to a family of rather similar sites, all of which feature the REGa defect

Optimal Data-Dependent Hashing for Approximate Near Neighbors

We show an optimal data-dependent hashing scheme for the approximate near neighbor problem. For an $n$-point data set in a $d$-dimensional space our data structure achieves query time $O(d n^{\rho+o(1)})$ and space $O(n^{1+\rho+o(1)} + dn)$, where $\rho=\tfrac{1}{2c^2-1}$ for the Euclidean space and approximation $c>1$. For the Hamming space, we obtain an exponent of $\rho=\tfrac{1}{2c-1}$. Our result completes the direction set forth in [AINR14] who gave a proof-of-concept that data-dependent hashing can outperform classical Locality Sensitive Hashing (LSH). In contrast to [AINR14], the new bound is not only optimal, but in fact improves over the best (optimal) LSH data structures [IM98,AI06] for all approximation factors $c>1$. From the technical perspective, we proceed by decomposing an arbitrary dataset into several subsets that are, in a certain sense, pseudo-random.Comment: 36 pages, 5 figures, an extended abstract appeared in the proceedings of the 47th ACM Symposium on Theory of Computing (STOC 2015

Lesions mimicking lacrimal gland pleomorphic adenoma

Aim: To report a series of patients with lacrimal gland lesions simulating the clinicoradiological features of lacrimal gland pleomorphic adenoma (LGPA). Methods: Multicentre retrospective, interventional case series. Clinical records of all patients with lesions mimicking LGPA seen in five orbital units were reviewed. Results: The study included 14 patients (seven men and seven women) with a mean age of 50.9 years. The diagnosis of LGPA was made in all cases by experienced orbital surgeons, based on clinicoradiological features, and lacrimal gland excision was performed. Postoperative histology revealed lymphoma (four patients), chronic dacryoadenitis (three patients), adenoid cystic carcinoma (two patients), Sjogren's syndrome (two patients), cavernous haemangioma (one patient), benign lymphoid hyperplasia (one patient) and granulomatous dacryoadenitis (one patient). Comparison with the total number of histologically confirmed LGPA cases seen during the study period revealed that 22.6% of cases of suspected LGPA were misdiagnosed based on clinicoradiological criteria. Conclusions: Many different lesions may mimic the clinicoradiological features of LGPA. The accepted clinicoradiological criteria used for the diagnosis of LGPA have a high false-positive rate, even in experienced hands. Based on this study, the authors believe that fine-needle aspiration biopsy or intraoperative biopsy and frozen section diagnosis may help reduce unnecessary lacrimal gland excision.Venkatesh C Prabhakaran, Paul S Cannon, Alan McNab, Garry Davis, Brett O’Donnell, Peter J Dolman, Raf Ghabrial, Dinesh Selv

Innovation Constructs: An Exploratory Study

Many organizations strive to improve performance by creating and marketing new products and/or services. Understanding why some new products and services succeed while others fail is critical to managers and marketing researchers. Diffusion of innovation theory addresses the reasons for, and rate of, the adoption of new ideas, products, and services. This theory and its related constructs have been successfully applied to new products while there has been less on emphasis on new services such as educational innovations. Further, research of educational innovations, has focused on adoption by teachers and administrators rather than students. This research study addresses this gap by empirically investigating whether diffusion of innovation theory and constructs apply to student adoption of new academic programs.  

A design research approach

The significance of the design process in determining the success or failure of a product in the market place is becoming increasingly more articulated. Consequently companies are implementing and developing new techniques and tools to support design more effectively. Design research is directed at gaining a greater understanding of design, ultimately to better support it through the development of improved techniques, methods or tools