On Optimum Sequencing of Job Shop Scheduling in Manufacturing Shop

Joh shop scheduling problem (JSSP) is an NP Hard problem. The most obvious real-world application of the JSSP is within manufacturing and machining as the parameter description describes. Companies that are able to optimize their machining schedules are able to reduce production time and cost in order to maximize profits. The aim of the problem is to find the optimum schedule for allocating shared resources over time to complete all n jobs within the problem. In this research we employ probability sequencing and make of comparison of job-shop sequencing rule such as first-come, first-served (FCFS) rule, which can be accomplished only by used of digital simulation. The result shown that using probability sequencing, when the machine is free, a job is selected in accordance with a sequencing rule and is allowed to occupy the machine for a time equal to its predetermined processing time. A job is complete when it has been processed through all centers on its route

Toxicological and Nutritional Evaluations of Milk Bush (Thevetia neriifolia) Seed Oil-Based Diet in Albino Rats

The seed oil of milk bush Thevetia neriifolia have been analyzed to provide some physical data for the oil and growth performance and toxicity evaluation in rats using the seed oil-based. The fatty acid composition of the oil was identified using Gas Chromatography (GC) and Gas Chromatography – Mass Spectrophotometer (GC-MS). The oil consist of 97.583%  fatty acid of which the most abundant is the monounsaturated  (C18H34O2) Oleic acid (52%), and the others are saturated fatty acids  (C18H36O2) Stearic acid (25%) and the other Palmitic acid (C16H32O2). The physicochemical studies of the seed oil showed: acid value of 0.515 ± 0.27; 117.125±2.38 mgKOH/g saponification value and 74.145 ± 0.784 iodine value. Growth performance was investigated in Wistar albino rats following a feeding period of 6weeks, using 5 %, 10 % and 15% of the oil compounded feed. We observed a significant decrease in body weight gain and feed intake in 10% and 15% oil-based feed group compared to control. The enzymatic antioxidant, biomarkers of kidney/liver toxicity and histopathology of visceral organs were evaluated. There was a significant (p < 0.05) increase in serum AST, and ALT of treated groups with respect to control group. Which explain its toxic nature. Keywords: chemical composition, characteristics, feed formulation, growth performance, toxicological evaluation

Long Term Effects of Streptozotocin Induced Diabetes Mellitus on Hepatic, Nephrotic and Cardiac Physiology of Female Wistar Rats

Background: Diabetes mellitus is a metabolic disorder which leads to complications that affect the heart, kidney, liver and other vital organs. Most reports on diabetes have focused on diabetes induction using male rat models in short term studies.Objective: Here, we described the induction of diabetes in female rat and the complications of diabetes following long term hyperglycemia in female Wistar rats.Method: Rats were assigned into two groups: control (n=10) and diabetic (n=10). The latter was administered a single (50mg/Kg body weight) intraperitoneal injection of streptozotocin. Bodyweight and blood glucose were assessed for 14 weeks, after which the animals were sacrificed and biochemical and morphology parameters of the liver, kidney and heart were determined.Results: Diabetic rats showed continuous emaciation post STZ induction. The glycated haemoglobin, protein level, lipid profile, liver and kidney function markers were significantly different (p<0.05) from the control. Catalase, superoxide dismutase and glutathione-s-transferase activities were also significantly reduced in the heart, liver and kidney, and a concomitant increase in malondialdehyde concentration was observed. Focal tubular necrosis, pulmonary congestion and mild hyperplasia of kupffer cells were observed in the tissues and all tissues showed negative CD79a expression.Conclusion: This study provides data that could be useful for modelling long-term diabetes mellitus studies in female experimental rat models