Effect of thyroparathyroidectomy on urinary acidification in diabetic rats

In previous studies we have shown stimulation of renal acid excretion in the proximal tubules of rats with diabetes of short duration, with no important alterations in glomerular hemodynamics; on the other hand, in thyroparathyroidectomized rats (TPTX model), a significant decrease in renal acid excretion, glomerular filtration rate (GFR) and renal plasma flow (RPF) was detected. Since important changes in the parathyroid hormone-vitamin D-Ca axis are observed in the diabetic state, the present study was undertaken to investigate the renal repercussions of thyroparathyroidectomy in rats previously made diabetic by streptozotocin (45 mg/kg). Four to 6 days after the induction of diabetes (DM), a group of rats were thyroparathyroidectomized (DM + TPTX). Renal functional parameters were evaluated by measuring the inulin and sodium para-aminohippurate clearance on the tenth day. The decrease in the GFR and RPF observed in TPTX was not reversed by diabetes since the same alterations were observed in DM + TPTX. Net acid (NA) excretion was unchanged in DM (6.19 ± 0.54), decreased in TPTX (3.76 ± 0.25) and returned to normal levels in DM + TPTX (5.54 ± 0.72) when compared to the control group (6.34 ± 0.14 µmol min-1 kg-1). The results suggest that PTH plays an important vasodilator role regarding glomerular hemodynamics, since in its absence the impairment in GFR and RPF was not reversed by the diabetic state. However, with respect to acid excretion, the presence of diabetes was able to overcome the negative stimulus represented by TPTX.Universidade Federal de São Paulo (UNIFESP)UNIFESPSciEL

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Effect of thyroparathyroidectomy on urinary acidification in diabetic rats

In previous studies we have shown stimulation of renal acid excretion in the proximal tubules of rats with diabetes of short duration, with no important alterations in glomerular hemodynamics; on the other hand, in thyroparathyroidectomized rats (TPTX model), a significant decrease in renal acid excretion, glomerular filtration rate (GFR) and renal plasma flow (RPF) was detected. Since important changes in the parathyroid hormone-vitamin D-Ca axis are observed in the diabetic state, the present study was undertaken to investigate the renal repercussions of thyroparathyroidectomy in rats previously made diabetic by streptozotocin (45 mg/kg). Four to 6 days after the induction of diabetes (DM), a group of rats were thyroparathyroidectomized (DM + TPTX). Renal functional parameters were evaluated by measuring the inulin and sodium para-aminohippurate clearance on the tenth day. The decrease in the GFR and RPF observed in TPTX was not reversed by diabetes since the same alterations were observed in DM + TPTX. Net acid (NA) excretion was unchanged in DM (6.19 ± 0.54), decreased in TPTX (3.76 ± 0.25) and returned to normal levels in DM + TPTX (5.54 ± 0.72) when compared to the control group (6.34 ± 0.14 µmol min-1 kg-1). The results suggest that PTH plays an important vasodilator role regarding glomerular hemodynamics, since in its absence the impairment in GFR and RPF was not reversed by the diabetic state. However, with respect to acid excretion, the presence of diabetes was able to overcome the negative stimulus represented by TPTX

Agregando forças, reunindo competências: parcerias para o desenvolvimento sustentável.

As parcerias multissetoriais, pelo potencial que apresentam para alavancar o desenvolvimento, receberam atenção especial no âmbito do Objetivo de Desenvolvimento Sustentável (ODS) 17, em que estão incluídas, entre as questões sistêmicas, duas metas especificamente dirigidas à celebração de parcerias: Meta 17.16 ? Reforçar a parceria global para o desenvolvimento sustentável, complementada por parcerias multissetoriais que mobilizem e compartilhem conhecimento, expertise, tecnologia e recursos financeiros, para apoiar a realização dos objetivos do desenvolvimento sustentável em todos os países, em particular nos países em desenvolvimento. Meta 17.17 ? Incentivar e promover parcerias públicas, público-privadas e com a sociedade civil eficazes, a partir da experiência de estratégias de mobilização de recursos dessas parcerias. Ainda que envolvam temas específicos distintos, ambas as metas têm como cerne a mobilização de recursos e o compartilhamento e uso de conhecimentos e experiências. Se, por um lado, os recursos são essenciais para a realização de quaisquer ações, por outro, é o compartilhamento e uso do estoque de conhecimentos e experiências que permitirá uma jornada mais eficaz rumo ao alcance dos ODS. Não se trata somente de replicar modelos bem-sucedidos de cooperação, mas de utilizar o conhecimento adquirido no dia a dia das parcerias para adaptar boas estratégias a novas demandas e geografias e, onde não for possível, ir além: criar modelos inovadores que guardem em si os elementos-chave de sucesso identificados nas experiências prévias. Neste capítulo, são apresentadas algumas parcerias multissetoriais em que a Empresa Brasileira de Pesquisa Agropecuária (Embrapa) participa. Não é intenção inventariar aqui todas as parcerias estabelecidas pela Empresa, tampouco descrever os muitos e relevantes resultados obtidos, mas sim destacar algumas estratégias de cooperação bem-sucedidas. Assim, procura-se indicar alguns caminhos e possibilidades que possam servir de inspiração e estímulo a instituições similares à Embrapa