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Overexpression of MMPs in Corneas Requiring Penetrating and Deep Anterior Lamellar Keratoplasty.
PurposeMatrix metalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases involved in wound healing processes, including neovascularization and fibrosis. We assessed MMP protein expression levels in diseased corneas of patients requiring penetrating and deep anterior lamellar keratoplasty. The purpose of this study was to test the hypothesis that upregulation of MMPs in diseased corneas is positively associated with clinical levels of corneal neovascularization and fibrosis.MethodsProtein expression levels of nine individual MMPs were quantified simultaneously in human corneal lysates by using the Bio-Plex Pro Human MMP 9-Plex Panel and the MAGPIX technology. Measurements of MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP12, and MMP13 were performed on diseased specimens from 21 patients undergoing corneal transplantation (17 for penetrating keratoplasty and 4 for deep anterior lamellar keratoplasty) and 6 normal control corneas.ResultsLuminex-based expression analysis revealed a significant overexpression of four of the nine MMPs tested (MMP2, MMP8, MMP12, and MMP13) in patient samples compared to control. Significant overexpression of MMP1, MMP2, MMP8, MMP12, and MMP13 was observed in diseased corneas with neovascularization compared with diseased corneas without neovascularization. Overexpression of MMP1, MMP2, MMP8, MMP12, and MMP13 also corresponded with the levels of corneal fibrosis. Finally, reduced expression of MMP3 was detected in keratoconus patients.ConclusionsMultiple MMPs are expressed in the corneas of patients with chronic disease requiring keratoplasty even when the pathologic process appears to be clinically inactive. In particular, the expression of several MMPs (MMP2, MMP8, MMP12, and MMP13) is positively associated with increased levels corneal fibrosis and neovascularization
Dust in the Ionized Medium of the Galaxy: GHRS Measurements of Al III and S III
We present interstellar absorption line measurements of the ions S III and Al
III towards six stars using archival Goddard High Resolution Spectrograph data.
The ions Al III and S III trace heavily depleted and non-depleted elements,
respectively, in ionized gas. We use the photoionization code CLOUDY to derive
the ionization correction relating N(Al III)/N(S III) to the gas-phase
abundance [Al/S]_i in the ionized gas. For spectral types considered here, the
corrections are small and independent of the assumed ionization parameter.
Using the results of these photoionization models, we find [Al/S]_i = -1.0 in
the ionized gas towards three disk stars. These values of [Al/S]_i (=[Al/H]_i)
imply that Al-bearing grains are present in the ionized nebulae around these
stars. If the WIM of the Galaxy is photoionized by OB stars, our data for two
halo stars imply [Al/S]_i = -0.4 to -0.5 in the WIM and thus the presence of
dust grains containing Al in this important phase of the ISM. While
photoionization appears to be the most likely origin of the ionization for Al
III and S III, we cannot rule out confusion from the presence of hot,
collisionally ionized gas along two sightlines. We find that [Al/S]_i in the
ionized gas along the six sightlines is anti-correlated with the electron
density and average sightline neutral density. The degree of grain destruction
in the ionized medium of the Galaxy is not much higher than in the warm neutral
medium. The existence of grains in the ionized regions studied here has
important implications for the thermal balance of these regions. (Abstract
Abridged)Comment: 30 pages including 8 embedded tables and 8 embedded figures. Accepted
for publication in the Astrophysical Journa
Signature of Electron Capture in Iron-Rich Ejecta of SN 2003du
Late-time near-infrared and optical spectra are presented for the
normal-bright SN2003du. At about 300 days after the explosion, the emission
profiles of well isolated [FeII] lines (in particular that of the strong
1.644mu feature) trace out the global kinematic distribution of radioactive
material in the expanding. In SN2003du, the 1.644 mu [FeII] line shows a
flat-topped, profile, indicative of a thick but hollow-centered expanding
shell, rather than a strongly-peaked profile that would be expected from a
``center-filled'' distribution.Based on detailed models for exploding
Chandrasekhar mass white dwarfs, we show that the feature is consistent with
spherical explosion models.Our model predicts central region of non-radioactive
electron-capture elements up to 2500--3000km/s as a consequence of burning
under high density, and an extended region of 56Ni up to 9,000--10,000km/s.
Furthermore our analysis indicates that the 1.644mu [FeII] profile is not
consistent with strong mixing between the regions of electron- capture isotopes
and the 56Ni layers as is predicted by detailed 3D models for nuclear
deflagration fronts. We discuss the possibility that the flat-topped profile
could be produced as a result of an infrared catastrophe and conclude that such
an explanation is unlikely. We put our results in context to other SNeIa and
briefly discuss the implications of our result for the use of SNe Ia as
cosmological standard candles.Comment: 12 pages + 8 figures, ApJ (in press, Dec. 20, 2004) For high
resolution figures send E-mail to [email protected]
Star Formation in M51 Triggered by Galaxy Interaction
We have mapped the inner 360'' regions of M51 in the 158micron [CII] line at
55'' spatial resolution using the Far-infrared Imaging Fabry-Perot
Interferometer (FIFI) on the Kuiper Airborne Observatory (KAO). The emission is
peaked at the nucleus, but is detectable over the entire region mapped, which
covers much of the optical disk of the galaxy. There are also two strong
secondary peaks at ~43% to 70% of the nuclear value located roughly 120'' to
the north-east, and south-west of the nucleus. These secondary peaks are at the
same distance from the nucleus as the corotation radius of the density wave
pattern. The density wave also terminates at this location, and the outlying
spiral structure is attributed to material clumping due to the interaction
between M51 and NGC5195. This orbit crowding results in cloud-cloud collisions,
stimulating star formation, that we see as enhanced [CII] line emission. The
[CII] emission at the peaks originates mainly from photodissociation regions
(PDRs) formed on the surfaces of molecular clouds that are exposed to OB
starlight, so that these [CII] peaks trace star formation peaks in M51. The
total mass of [CII] emitting photodissociated gas is ~2.6x10^{8} M_{sun}, or
about 2% of the molecular gas as estimated from its CO(1-0) line emission. At
the peak [CII] positions, the PDR gas mass to total gas mass fraction is
somewhat higher, 3-17%, and at the secondary peaks the mass fraction of the
[CII] emitting photodissociated gas can be as high as 72% of the molecular
mass.... (continued)Comment: 14 pages, 6 figures, Accepted in ApJ (for higher resolution figures
contact the author
Quantifying year-round nocturnal bird migration with a fluid dynamics model.
To understand the influence of biomass flows on ecosystems, we need to characterize and quantify migrations at various spatial and temporal scales. Representing the movements of migrating birds as a fluid, we applied a flow model to bird density and velocity maps retrieved from the European weather radar network, covering almost a year. We quantified how many birds take-off, fly, and land across Western Europe to (1) track bird migration waves between nights, (2) cumulate the number of birds on the ground and (3) quantify the seasonal flow into and out of the study area through several regional transects. Our results identified several migration waves that crossed the study area in 4 days only and included up to 188 million (M) birds that took-off in a single night. In spring, we estimated that 494 M birds entered the study area, 251 M left it, and 243 M birds remained within the study area. In autumn, 314 M birds entered the study area while 858 M left it. In addition to identifying fundamental quantities, our study highlights the potential of combining interdisciplinary data and methods to elucidate the dynamics of avian migration from nightly to yearly time scales and from regional to continental spatial scales
The Atomic Physics Underlying the Spectroscopic Analysis of Massive Stars and Supernovae
We have developed a radiative transfer code, CMFGEN, which allows us to model
the spectra of massive stars and supernovae. Using CMFGEN we can derive
fundamental parameters such as effective temperatures and surface gravities,
derive abundances, and place constraints on stellar wind properties. The last
of these is important since all massive stars are losing mass via a stellar
wind that is driven from the star by radiation pressure, and this mass loss can
substantially influence the spectral appearance and evolution of the star.
Recently we have extended CMFGEN to allow us to undertake time-dependent
radiative transfer calculations of supernovae. Such calculations will be used
to place constraints on the supernova progenitor, to place constraints on the
supernova explosion and nucleosynthesis, and to derive distances using a
physical approach called the "Expanding Photosphere Method". We describe the
assumptions underlying the code and the atomic processes involved. A crucial
ingredient in the code is the atomic data. For the modeling we require accurate
transition wavelengths, oscillator strengths, photoionization cross-sections,
collision strengths, autoionization rates, and charge exchange rates for
virtually all species up to, and including, cobalt. Presently, the available
atomic data varies substantially in both quantity and quality.Comment: 8 pages, 2 figures, Accepted for publication in Astrophysics & Space
Scienc
A Quantum Dot in the Kondo Regime Coupled to Superconductors
The Kondo effect and superconductivity are both prime examples of many-body
phenomena. Here we report transport measurements on a carbon nanotube quantum
dot coupled to superconducting leads that show a delicate interplay between
both effects. We demonstrate that the superconductivity of the leads does not
destroy the Kondo correlations on the quantum dot when the Kondo temperature,
which varies for different single-electron states, exceeds the superconducting
gap energy
ORFEUS II and IUE Spectroscopy of EX Hydrae
Using ORFEUS-SPAS II FUV spectra, IUE UV spectra, and archival EUVE deep
survey photometry, we present a detailed picture of the behavior of the
magnetic cataclysmic variable EX Hydrae. Like HUT spectra of this source, the
FUV and UV spectra reveal broad emission lines of He II, C II-IV, N III and V,
O VI, Si III-IV, and Al III superposed on a continuum which is blue in the UV
and nearly flat in the FUV. Like ORFEUS spectra of AM Her, the O VI doublet is
resolved into broad and narrow emission components. Consistent with its
behavior in the optical, the FUV and UV continuum flux densities, the FUV and
UV broad emission line fluxes, and the radial velocity of the O VI broad
emission component all vary on the spin phase of the white dwarf, with the
maximum of the FUV and UV continuum and broad emission line flux light curves
coincident with maximum blueshift of the broad O VI emission component. On the
binary phase, the broad dip in the EUV light curve is accompanied by strong
eclipses of the UV emission lines and by variations in both the flux and radial
velocity of the O VI narrow emission component. The available data are
consistent with the accretion funnel being the source of the FUV and UV
continuum and the O VI broad emission component, and the white dwarf being the
source of the O VI narrow emission component.Comment: 21 pages, 10 Postscript figures; LaTeX format, uses aaspp4.sty;
table2.tex included separately because it must be printed sideways - see
instructions in the file; accepted on 1999 Feb 20 for publication in The
Astrophysical Journa
The nuclear spectrum of the radio galaxy NGC 5128 (Centaurus A)
We present near-infrared spectra of the nuclear disk in the nearby radio
galaxy NGC 5128 (Centaurus A). On the basis of the observed strengths of the [S
III] 0.9532um and [Fe II] 1.2567um lines, we classify NGC 5128 as a LINER.
Modeling of the strengths of these and additional lines suggests that the
nuclear region is powered by shocks rather than photoionization.Comment: 12 pages including 2 figures, accepted by ApJ Letter
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