Rarely seen rectum tumor with bad prognosis: A case of large cell neuroendocrine carcinoma

Large cell neuoendocrine carcinoma forms an extremely aggressive and poor prognostic subset of neuroendocrine tumors with a tendency to early metastasis. However palliative chemotherapy in patients with metastatic disease may provide longer progression-free survival but the important issue is to detect and surgically treat the disease at an early stage. In this article, we  present a case of  large cell neuroendocrine carcinoma of the rectum which was admitted to our hospital with a complaint of rectal bleeding for about a month and multiple dsitant metastases at the time of diagnosis. The patient received palliative chemotherapy with cisplatin plus etoposide and zoledronic acid and an overall 6 month survival time was achieved. Generalizing the screening programs for colorectal cancers and facilitating access to colonoscopy are essential for early diagnosis and therapy of rectal neuroendocrine tumors.</p

Amyad's hernia while reparing the bilateral inguinal hernia

Amyand's hernia is the term used for inguinal hernia containing appendix. It is a rare condition and found in 1% of inguinal hernia repairs. Here we report a case of Amyand's hernia in a 61 years old male who was diagnosed with bilateral inguinal hernia. He underwent surgery and bilateral inguinal hernia repair with prosthetic meshes and without appendectomy. The patient was discharged uneventfully. </p

Malignant fibrous histiocytoma of the abdominal wall

Malignant fibrous histiocytoma (MFH) or undifferentiated pleomorphic sarcoma is a type of malignt neoplasm that arises from any soft tissue and bone involving extremities, abdomen and retroperitoneum. MFH of the external oblique abdominis muscle is rare. Surgical resection of the mass is the treatment of choice depending on the stage of the disease and the invasion depth of the tumor. Radiotherapy, chemotherapy and immunotherapy are the other treatment methods. We present a case of a 71-year old man with the diagnosis of MFH on external oblique muscle which was completely resected. We believe that adjuvant chemoradiotherapy following surgical resection of the tumor was the most appropriate treatment for this disease.</p

Effects of obesity on retrobulbar flow hemodynamics: color Doppler ultrasound evaluation

<div><p>ABSTRACT Purpose: To evaluate intraocular pressure (IOP) and extraocular orbital vessels with color Doppler ultrasound (CDU) and investigate the effects of obesity on retrobulbar blood flow. Methods: Fifty-nine patients were included in this prospective study. Patients were divided into two groups according to body mass index: Group 1 (31 obese patients) and Group 2 (28 non-obese patients). IOP was measured with a Goldmann applanation tonometer, and CDU was used to evaluate the retrobulbar vessels. Results: The mean IOP was 18 ± 6.68 mmHg in the obese group and 13.71 ± 1.60 mmHg in the control group (p<0.001). When the CDU values for the central retinal artery were compared between the groups, the pulsatility index was found to be significantly lower in the obese group than in the control group (p<0.001). When the CDU values for the ophthalmic artery (OA) were compared between the groups, the peak systolic velocity (p<0.001) and end-diastolic velocity (p=0.002) values were found to be significantly lower in the obese group than in the control group. Conclusions: Obese patients have a higher mean IOP and lower flow velocity than non-obese patients. Increased IOP together with decreased retrobulbar blood flow, particularly in obese individuals, may increase the risk of glaucoma development.</p></div