The Effects of Intravitreal Dexamethasone Implant (Ozurdex®) on Intraocular Pressure and Anterior Chamber Angle

Amaç: İntravitreal deksametazon enjeksiyonunun göz içi basıncı (GİB) ve ön kamara açısı (ÖKA) üzerine etkisini incelemek. Gereç ve Yöntem: Otuz sekiz hastanın 40 gözü incelendi. Hastaların yaş ortalaması 61.39 yıl (aralık: 36-83) olup, %63.2’i kadın, %36.8’i erkekti. %70'i retina ven tıkanıklığı, %20’i diabet, %7.5‘i arka üveit ve %2.5’i psödofakik makula ödemi olgusuydu. GİB Goldmann ap- lanasyon tonometresi ile ölçüldü. GİB ve gonyoskopik muayene enjeksiyondan önce ve enjeksiyondan sonra 1.hafta, 1. 3. ve 6. aylarda ölçüldü. Spektral domain optik koherans tomografi (OKT) enjeksiyon öncesi ve sonrası 1. ay, 3. ay ve 6. ay da üst, nazal, alt, temporal kad- ranlardan alındı. OKT ile ön kamara açı derecesi (ÖKA), trabeküler iris yüzey alanı (TIYA500) ve açı açılma mesafesi (AAM500) ölçüldü. Bulgular: Enjeksiyon yapılan gözlerin GİB'ı enjeksiyon öncesi, enjeksiyon sonrası 1. hafta, 1. ve 3. aylardakine göre anlamlı düşük sap- tandı (sırasıyla p= 0.004, p= 0.002, p= 0.003). Enjeksiyon sonrası 6. ay ile enjeksiyon öncesi arasında ortalama GİB değerleri açısından anlamlı fark izlenmedi. Nazal kadranda enjeksiyon öncesi ve sonrası 1. haftadaki gonyoskopik derece, enjeksiyon sonrası 3. ve 6. aylara göre anlamlı yüksek saptandı (p= 0.007, p= 0,006; p= 0.008, p= 0,008). Gonyoskopide diğer kadranlarda anlamlı fark saptanmadı. Nazal kadranda OKT-ÖKA'nın enjeksiyon sonrası 3. ve 6. aydaki değerleri, enjeksiyon öncesi ve sonrası 1. aya göre anlamlı dar saptandı (p= 0.008, p= 0,008; p= 0.009, p= 0,008). Üst kadranda göz kapağı güvenilir ölçüm alınmasına engel olmuştur. Uygulama yapılan gözlerin alt kadran 3. ve 6. aylardaki OKT-AAM500 ve TİYA500 sonucu enjeksiyon öncesinden anlamlı olarak düşük saptanmıştır (p= 0.002, p= 0.004; p= 0.005, p= 0.001). Sonuç: İntravitreal deksametazon enjeksiyonu sonrası göz içi basıncı artabilir fakat çoğu olguda medikal tedaviyle kontrol altına alınabilir. Enjeksiyon sonrası gonyoskopide ve OKT’de bazı kadranlarda ön kamara açısında daralma olabilir.Purpose: To investigate the effects of intravitreal dexamethasone injection on intraocular pressure (IOP) and anterior chamber angle (ACA). Materials and Methods: Forty eyes of 38 patients were studied. The mean age of the patients was 61.39 years (range: 36-83), 63.2% female and 36.8% male. 70% were retinal vein occlusion, 20% were diabetic, 7.5% were posterior uveitis and 2.5% were pseudophakic macular edema. IOP was measured by Goldman applanation tonometry. IOP and gonioscopic examination were performed before and after injection on the 1st week 1st, 3rd, and 6th months. Spectral domain optic coherence tomography (OCT) was performed on the superior, nasal, inferior, temporal quadrants before and after injection on the 1st, 3rd, and 6th months. Anterior chamber angle (ACA), trabecular iris surface area (TISA500) and angle opening distance (AOD500) were measured by OCT

Rewarding Systems And Rewarding Effect Motivation On The Application In The Construction Sektor

Modern yönetim araçlarından biri de güdülemedir. Güdüleme, yöneticinin kullanacağı etkin bir araçtır. Güdüleme ile çalışanların fiziki, zihinsel ve ruhsal güçlerinin çok daha fazlası üretim sürecine aktarılmaya çalışılır. Çalışanların güdülenmelerini artıran yöntemlerden biri de çalışanların ödüllendirilmesidir. Bu çalışmanın amacı, işletmelerde kurulan ödüllendirme sistemlerinin çalışanların güdülenmelerini etkileyip etkilemediğini incelemektir. Bu amaçla Gama Endüstri A.Ş'de çalışanların ödüllendirme ile güdülenme konusunda neler düşündükleri anket yoluyla tespit edilmeye çalışılmıştır. Çalışmanın teorik kısmında yerli ve yabancı bilim adamlarının kitap ve makalelerinden yararlanılmıştır. Çalışma üç bölümden oluşmaktadır. Birinci bölümde, güdüle(n)menin tanımı, önemi, süreci, güdüleme kuramları ve ödüllendirmenin güdüleme açısından önemi açıklanmıştır. İkinci bölümde ödüllendirme sistemlerinin kavramsal çerçevesi, ödül türleri, ödül sınıflandırılması yapılmış ve ödül sistemleri açıklanmıştır. Üçüncü bölümde ise, beşli likert ölçeğine uygun olarak düzenlenen anket işletmeye uygulanmıştır. Anket yoluyla işletmeden toplanan verilerin analiz ve yorumlanması yapılmıştır. Değerlendirme bölümünde istatistiksel yöntemler kullanılarak sonuca varılmıştır.One of modern management tools are motivation. Motivation is one of the effective tools of the manager's. By motivation, the physical mental and spiritual strength of employees' much more work is trying to be transferred to the production process. One of the ways of increasing the employees' motivation is to reward employees. The purpose of this study, is to examine whether the rewarding system established at the enterprises affects the employees motivation or not. For this purpose, it is trying to be identified through the survey that what the employees working at Gama Industries Inc. thinks about the motivation by rewarding. Working in the theoretical part, have been benefiting from the local and foreign scientists' book and articles. The study consists of three parts. Motivation in the first chapter of its definition, importance, process, theory of motives and identifying the importance of motivation rewarding. In the second chapter, conceptual framework of reward system, reward type, reward and reward systems of classification are described. In the third chapter, the questionnaire organized according to the five liker scale was applied to business. The data collected from the enterprises through the survey is analyzed and interrelated. In the evaluation part, by using statistical methods is reached to the resultr

Intravitreal Dexamethasone Implant (Ozurdex) for Refractory Macular Edema Secondary to Retinitis Pigmentosa

Retinitis pigmentozadaki (RP) maküla ödemi (MÖ), merkezi görmeyi sıklıkla dramatik biçimde bozar. RP tanılı 41 yaşındaki kadın her iki gözünde ileri seviyede görme bozulmasıyla polikliniğimize başvurmuştu. Hasta topikal karbonik anhidraz inhibitörleri, topikal kortikosteroitler ve intravitreal triamsinolon asetonid enjeksiyonları ile tedavi edildi, fakat MÖ devam ediyordu. Hastanın her iki gözüne komplikasyonsuz 0,7 mg deksamethasone implant (Ozurdex, Allergan) uygulandı. Her iki enjeksiyondan dört gün sonra görme keskinliği arttı ve MÖ neredeyse tama yakın düzeldi. Altı aylık takip süresince hastalıkta tekrarlama izlenmedi.Macular edema (ME) in retinitis pigmentosa (RP) often impairs central vision dramatically. A 41-year-old woman diagnosed with RP was referred to our outpatient clinic due to severe visual deterioration in both eyes. The patient was treated with topical carbonic anhydrase inhibitors, topical corticosteroids and intravitreal triamcinolone acetonide injections, but her ME recurred. Intravitreal 0.7 mg dexamethasone implant (Ozurdex, Allergan) was administered into both eyes without complications. On the fourth day after both injections, visual acuity improved and ME almost totally resolved. No recurrence was observed at follow-up six months later

Retinal nerve fiber layer thickness in vitiligo patients

Ornek, Nurgul/0000-0003-3068-1831WOS: 000328107400009PubMed: 24174946Background: This study was designed to investigate the effect of vitiligo on the retinal nerve fiber layer (RNFL) thickness. Materials and Methods: This prospective study was conducted in the Department of Ophthalmology at Kirikkale University during 2010 and 2011. Sixty eight eyes of 34 vitiligo patients were included in the study. Eighty four eyes were served as control. RNFL thickness was measured by scanning laser polarimetry (Nerve Fiber Analyzer, GDx VCC: 5.3.3; Laser Diagnostic Technologies, San Diego, CA, USA). Results: The mean duration of vitiligo was found to be 9.8 +/- 2.3 years. The mean average RNFL thickness outside the disc margin was significantly lower in the right eyes of vitiligo group in comparison to the controls (P = 0.02). The mean average thickness of RNFL beneath the measuring ellipse in the superior sector of both eyes were significantly lower than the controls (P = 0.004, P = 0.008, respectively). The topographical distributions of RNFL thickness in superior, inferior, nasal and temporal quadrants were similar for two groups. Conclusion: RNFL thickness seems to be unaffected in vitiligo patients

Retinal nerve fiber layer thickness in vitiligo patients

Background: This study was designed to investigate the effect of vitiligo on the retinal nerve fiber layer (RNFL) thickness. Materials and Methods: This prospective study was conducted in the Department of Ophthalmology at Kýrýkkale University during 2010 and 2011. Sixty eight eyes of 34 vitiligo patients were included in the study. Eighty four eyes were served as control. RNFL thickness was measured by scanning laser polarimetry (Nerve Fiber Analyzer, GDx VCC: 5.3.3; Laser Diagnostic Technologies, San Diego, CA, USA). Results: The mean duration of vitiligo was found to be 9.8 ΁ 2.3 years. The mean average RNFL thickness outside the disc margin was significantly lower in the right eyes of vitiligo group in comparison to the controls ( P = 0.02). The mean average thickness of RNFL beneath the measuring ellipse in the superior sector of both eyes were significantly lower than the controls ( P = 0.004, P = 0.008, respectively). The topographical distributions of RNFL thickness in superior, inferior, nasal and temporal quadrants were similar for two groups. Conclusion: RNFL thickness seems to be unaffected in vitiligo patients

Cystoid macular edema following selective laser trabeculoplasty in a patient with ocular hypertension

Gokcinar, Nesrin Buyuktortop/0000-0001-7795-5188WOS: 000482134100027PubMed: 30105491Purpose Presentation of a case with ocular hypertension who developed cystoid macular edema (CME) following selective laser trabeculoplasty (SLT). Case report A 62-year-old male patient who had undergone phacoemulsification surgery for traumatic cataract 9 years ago was on ocular hypertension treatment for the last 5 years. Due to uncontrolled intraocular pressure and side effect of medications, a 360 degrees SLT was performed. The patient returned with decrased visual acuity 1 week after the procedure. There was CME in the treated eye. It healed completely after topical prednisolone acetate QID and nepafenac QID for 1 week, and no recurrence was observed during follow-ups. Conclusion Cystoid macular edema may occur following SLT treatment in patients with previous traumatic cataract surgery which responds to topical treatment

Plasma adropin level in patients with pseudoexfoliation

Ornek, Nurgul/0000-0003-3068-1831;WOS: 000383601800020PubMed: 26861473The aim of this study was to evaluate plasma adropin levels in patients with pseudoexfoliation (PEX). This retrospective case-control study included 35 patients with PEX and 35 individuals without PEX who served as controls. Plasma adropin levels with triglycerides, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and haemoglobin A1c (HGBA1C) concentrations were measured in both groups. The mean serum adropin levels were 3.24 +/- 0.95 ng/mL (range, 1.90-7.88 ng/mL) in patients with PEX syndrome and 5.78 +/- 2.85 ng/mL (range, 2.08-5.41 ng/mL) in PEX glaucoma patients. There was no statistically significant difference in mean adropin levels between PEX syndrome and PEX glaucoma patients. However, similar adropin levels were found in the PEX glaucoma patients and the control group (P > 0.05). The mean serum adropin levels were 3.34 +/- 0.89 ng/mL (range, 1.90-5.39 ng/mL) in the PEX group and 5.78 +/- 2.85 ng/mL (range, 3.08-11.06 ng/mL) in the control group. The mean serum adropin level of the PEX group was significantly lower than that of the control group (P 0.05). Adropin level is lower in patients with PEX

Oksitosine Bağlı İki Taraflı Seröz Retina Dekolmanı

A 27-year-old multigravid patient was admitted with bilateral blurring of vision after caesarean delivery. She had history of oxytocin infusion for labor stimulation. Visual acuities were 1/10 in both eyes. Fundus examination showed bilateral serous retinal detachments affecting predominantly the posterior pole and the peripapillary area. Optical coherence tomography revealed bilateral serous retinal detachment of the macular area. Spontaneous resorption of the subretinal fl uid started promptly the following day after the delivery. Large volumes of hypotonic solution with oxytocin may induce water retension during labor. This should be considered in the differential diagnosis of bilateral serous RD in pregnancy.Yirmi yedi yaşında multigravid hasta sezaryenle doğum sonrası iki taraflı görme bulanıklığı ile başvurdu. Doğumu uyarmak amacıyla oksitosin infüzyonu hikayesi vardı. Görme keskinliği her iki gözde de 1/10 düzeyindeydi. Fundus muayenesi özellikle arka kutbu ve peripapiller alanı etkileyen bilateral seröz retina dekolmanı göstermekteydi. Optik koherens tomografi de iki gözde makula bölgesinde seöz retina dekolmanı mevcuttu. Doğum sonrası ikinci günde subretinal sıvı kendiliğinden çekilmeye başladı. Doğum öncesi çok miktarda hipotonik sıvı ile birlikte oksitosin kullanımı sıvı retansiyonuna neden olabilmektedir. Gebelik döneminde iki taraflı seröz retina dekolmanı ayırıcı tanısında bu durum göz önünde bulundurulmalıdır

Effect of 1% brinzolamide and 0.5% timolol fixed combination on intraocular pressure after cataract surgery with phacoemulsification

<b>AIM:</b> To evaluate the effect of brinzolamide-timolol fixed combination on intraocular pressure (IOP) after cataract surgery.<b>METHODS:</b>The study included 92 eyes of 87 patients who underwent cataract surgery and intraocular lens implantation. Patients scheduled for phacoemulsification were assigned to 1 of 2 groups. The treatment group received 1 drop of brinzolamide-timolol fixed combination immediately after surgery, and the control group received no treatment. The IOP was measured preoperatively and at 2h and 24h postoperatively.<b>RESULTS:</b> The mean IOP change was lower in the treatment group than in the control group at 2h postoperatively. The difference between the mean IOP values of the two groups at 2h postoperatively was found to be statistically significant. Twenty-four hours after the surgery, the mean IOP change was still higher in the control group when compared to the treatment group.<b>CONCLUSION:</b> The fixed combination brinzolamide-timolol can effectively reduce IOP after cataract surgery