273 research outputs found
Models of unionism and unemployment
We investigate the problem of simultaneous determination of labour market institutions and outcomes in single equation multi-country estimations by presenting an empirical analysis of unemployment and union density in 20 OECD countries. When explicitly modelling potential endogeneity and heterogeneity, our results suggest that unions contribute to explaining unemployment in different ways than previously thought. In addition, the relationship between unemployment and union density is heterogeneous across countries, depending on the way in which income support for the unemployed is organize
Long Process Incus necrosis in Revision Stapedotomy: Retrospective Clinical Study
Objectives: We describe our experience with long process incus (LPI) necrosis in revision stapedotomy and discuss the different management methods proposed in the literature to identify surgical techniques that can lead to satisfactory results over time. Methods: Twenty-two stapedotomy revisions, in 21 patients with the necrosis of the long process of the incus, are performed from 1997 to 2017. In cases of erosion or minimal necrosis of LPI, a new prosthesis of the same type or an angled prosthesis was applied higher on the residual incus stump. In cases of partial necrosis of LPI, a Donaldson type ventilation tube reshaped and placed on the residual incus stump to stabilize prosthesis, or glass ionomer bone cement was used. In cases of subtotal necrosis of LPI, a cup piston prosthesis in polycel was applied on incus residual stump. Pre- and postoperative (≥1 year) pure tone audiometry was performed for all cases. Air conduction threshold, bone conduction (BC) threshold, and air-bone gap (ABG) were documented according to the American Academy of Otolaryngology Head and Neck Surgery Committee of Hearing and Equilibrium guidelines. Results: At 1-year follow-up, postoperative ABG was reduced to ≤10 dB in 13 (59%) cases and ≤20 dB in 19 (86.4%) cases. The mean postoperative ABG significantly decreased in each group. There was no significant change in postoperative BC thresholds, and there were no cases with postoperative SNHL. Conclusion: Excellent functional results can also be achieved in cases of long incus process necrosis. The choice of technique should be considered according to the degree of necrosis. Piston replacement with the same type or angled type prosthesis, in cases of erosion or minimal LPI necrosis, and modified Donaldson type ventilation tube, in cases of partial LPI necrosis, provided excellent hearing results
An unsupervised behavioral modeling and alerting system based on passive sensing for elderly care
Artificial Intelligence in combination with the Internet of Medical Things enables remote healthcare services through networks of environmental and/or personal sensors. We present a remote healthcare service system which collects real-life data through an environmental sensor package, including binary motion, contact, pressure, and proximity sensors, installed at households of elderly people. Its aim is to keep the caregivers informed of subjects’ health-status progressive trajectory, and alert them of health-related anomalies to enable objective on-demand healthcare service delivery at scale. The system was deployed in 19 households inhabited by an elderly person with post-stroke condition in the Emilia–Romagna region in Italy, with maximal and median observation durations of 98 and 55 weeks. Among these households, 17 were multi-occupancy residences, while the other 2 housed elderly patients living alone. Subjects’ daily behavioral diaries were extracted and registered from raw sensor signals, using rule-based data pre-processing and unsupervised algorithms. Personal behavioral habits were identified and compared to typical patterns reported in behavioral science, as a quality-of-life indicator. We consider the activity patterns extracted across all users as a dictionary, and represent each patient’s behavior as a ‘Bag of Words’, based on which patients can be categorized into sub-groups for precision cohort treatment. Longitudinal trends of the behavioral progressive trajectory and sudden abnormalities of a patient were detected and reported to care providers. Due to the sparse sensor setting and the multi-occupancy living condition, the sleep profile was used as the main indicator in our system. Experimental results demonstrate the ability to report on subjects’ daily activity pattern in terms of sleep, outing, visiting, and health-status trajectories, as well as predicting/detecting 75% hospitalization sessions up to 11 days in advance. 65% of the alerts were confirmed to be semantically meaningful by the users. Furthermore, reduced social interaction (outing and visiting), and lower sleep quality could be observed during the COVID-19 lockdown period across the cohort
Glottic-SubGlottic adenoid cystic carcinoma. A case report and review of the literature
Background: Malignant tumours of minor salivary glands are uncommon, representing only 2-4% of all head and
neck cancers. In the larynx, minor salivary gland tumours rarely occur and constitute less than 1% of laryngeal
neoplasm. Most of the minor salivary gland tumours arise in the subglottis; however, they can also occur in the
supraglottis, in the false vocal cords, aryepiglottic folds and caudal portion of the epiglottis. The most common
type of malignant minor salivary gland tumour is adenoid cystic carcinoma.
Methods: We present a unusual case of adenoid cystic carcinoma of glottic-subglottic region in a 61-year-old
woman. Follow-up endoscopy and laryngeal magnetic resonance imaging (MRI) at three years after treatment
showed no recurrence of the tumour.
Results: The diagnosis of glottic-subglottic adenoid cystic carcinoma should be considered in patients who are
characterized by dyspnea, cough and stridor, but do not respond to pharmacologic approach.
Conclusions: Adenoid cystic carcinoma is usually a very slow growing cancer, invested by an apparently normal
laryngeal mucosa, so that it can show no clear symptoms for a long time. For these reasons the increasing number
of diagnostic mistakes or late diagnosis that may be fatal in some case
Effects of Direct-Acting Antiviral Agents on the Mental Health of Patients with Chronic Hepatitis C: A Prospective Observational Study
In chronic hepatitis C (CHC) patients, interferon-based treatments showed toxicity, limited
e cacy, and psychiatric manifestations. Direct-acting antiviral (DAA) agents appeared safer, though
it remains unclear if they may exacerbate or foster mood symptoms in drug-naïve CHC patients.
We evaluated 62 CHC patients’ mental status, before and 12 weeks after DAA therapy, by assessment
scales and psychometric instruments. We subdivided patients into two groups, CHC patients with
(Group A) or without (Group B) a current and/or past psychiatric history. After DAA treatment,
Group A patients showed low anxiety and improved depression, no variation in self-report distress,
but worse general health perceptions. No significant di erence emerged from coping strategies.
Depression and anxiety improved in Group B, and no change emerged from total self-reported distress,
except for somatization. Moreover, Group B increased problem-focused strategies for suppression of
competing activities, and decreased strategies of instrumental social support. Contrarily, Group B
reduced significantly emotion-focused strategies, such as acceptance and mental disengagement, and
improved vitality, physical and social role functioning. DAA therapy is safe and free of hepatological
and psychiatric side e ects in CHC patients, regardless of current and/or past psychiatric history.
In particular, patients without a psychiatric history also remarkably improved their quality of life
Association between Coagulation Profile and Clinical Outcome in Children with SARS-CoV-2 Infection or MIS-C: A Multicenter Cross-Sectional Study
Limited data on the coagulation profile in children affected by the SARS-CoV-2 infection are available. We aimed to evaluate the role of d-dimers as predictors of poor outcomes in a pediatric population affected by the SARS-CoV-2 infection or multisystem inflammatory syndrome (MIS-C). We performed a retrospective cross-sectional multicenter study. Data from four different centers were collected. Laboratory tests, when performed, were collected at the time of diagnosis, and 24, 48, 72, 96, 120 and beyond 120 h from diagnosis; blood counts with formula, an international normalized ratio (INR), activated partial thromboplastin time (aPTT), D-dimers and fibrinogen values were collected. Data regarding clinical history, management and outcome of the patients were also collected. Three hundred sixteen patients with a median age of 3.93 years (IQR 0.62–10.7) diagnosed with COVID-19 or MIS-C were enrolled. Fifty-eight patients (18.3%) showed a severe clinical outcome, 13 (4.1%) developed sequelae and 3 (0.9%) died. The univariate analysis showed that age, high D-dimer values, hyperfibrinogenemia, INR and aPTT elongation, and low platelet count were associated with an increased risk of pediatric intensive care unit (PICU) admission (p < 0.01). Three multivariate logistic regressions showed that a d-dimer level increase was associated with a higher risk of PICU admission. This study shows that D-dimer values play an important role in predicting the more severe spectrum of the SARS-CoV-2 infection, and was higher also in those that developed sequelae, including long COVID-19
Minimally invasive approach for adrenal lesions: Systematic review of laparoscopic versus retroperitoneoscopic adrenalectomy and assessment of risk factors for complications
In the last decades, minimally invasive transperitoneal laparoscopic adrenalectomy has become the standard of care for surgical resection of the adrenal gland tumors. Recently, however, adrenalectomy by a mininvasive retroperitoneal approach has reached increasingly popularity as alternative technique. Short hospitalization, lower postoperative pain and decrease of complications and a better cosmetic resolution are the main advantages of these innovative techniques. In order to determine the better surgical management of adrenal neoplasms, the Authors analyzed and compared the feasibility and the postoperative complications of minimally invasive adrenalectomy approaches. A systematic research of the English literature, including major meta-analysis articles, clinical randomized trials, retrospective studies and systematic reviews was performed, comparing laparoscopic transperitoneal adrenalectomy versus retroperitoneoscopic adrenalectomy. Many studies support that posterior retroperitoneal adrenalectomy is superior or at least comparable to laparoscopic transperitoneal adrenalectomy in operation time, pain score, blood loss, hospitalization, complications rates and return to normal activity. However, laparoscopic transperitoneal adrenalectomy is up to now a safe and standardized procedure with a shorter learning curve and a similar low morbidity rate, even for tumors larger than 6 cm. Nevertheless, further studies are needed to objectively evaluate these techniques, excluding selection bias and bias related to differences in surgeons' experiences with this approaches. (c) 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved
The novel variant p.Ser465Leu in the PCSK9 gene does not account for the decreased LDLR activity in members of a FH family
Understanding variation in salamander ionomes: A nutrient balance approach
Ecological stoichiometry uses information on a few key biological elements (C, N, and P) to
explain complex ecological patterns. Although factors driving variation in these elements are
well-established, expanding stoichiometric principles to explore dynamics of the many other
essential elements comprising biological tissues (i.e., the ionome) is needed to determine their
metabolic relationships and better understand biological control of elemental flows through
ecosystems.
2. In this paper, we report observations of ionomic variation in two species of salamander
(Ambystoma opacum and A. talpoideum) across ontogenic stages using specimens from
biological collections of two wetlands sampled over a 30-year period. This unique data set
allowed us to explore the extent of ionomic variation between species, among ontogenic stages,
between sites, and through time.
3. We found species- and to a lesser extent site-specific differences in C, N, and P along with 13
other elements forming salamander ionomes but saw no evidence of temporal changes.
Salamander ionomic composition was most strongly related to ontogeny with relatively higher
concentrations of many elements in adult males (i.e., Ca, P, S, Mg, Zn, and Cu) compared to
metamorphic juveniles, which had greater amounts of C, Fe, and Mn.
4. In addition to patterns of individual elements, covariance among elements was used to
construct multi-elemental nutrient balances, which revealed differences in salamander elemental
composition between species and sites and changes in elemental proportions across ontogenic
development. These multi-elemental balances distinguished among species-site-ontogenic stage
groups better than using only C, N, and P.
5. Overall, this study highlights the responsiveness of consumer ionomes to life-history and
environmental variation while reflecting underlying relationships among elements tied to
biological function. As such, ionomic studies can provide important insights into factors shaping
consumer elemental composition and for predicting how these changes might affect higher-order
ecological processes
Does religion influence entrepreneurial behaviour?
Religion cannot be ignored in assessing the range of cultural and institutional influences that impact on entrepreneurial activity. This article integrates key themes from sociology of religion in the context of emerging ideas about religion and entrepreneurship in order to highlight key research questions. New institutional theory is discussed as a potentially useful lens for viewing the range of means through which religious expression and institutions might support entrepreneurship. A macro-level empirical investigation of societal indicators of religious affiliation and regulation of religion alongside Global Entrepreneurship Monitor data highlights particular data correlations and mediating influences. A significant association between entrepreneurial activity and evangelical or Pentecostal Christian religious affiliation is found, along with evidence that the impact of religion on entrepreneurship is mediated through pluralism and regulation. In discussing these findings further, the article proposes a more integrated conceptual framework for understanding the link between religious drivers and entrepreneurship, alongside institutional mediation. This forms the basis for further research, focusing on individual experience rather than aggregate associations and exploring in further depth of the mediating impact of institutional arrangements
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