Crescimento e desenvolvimento de pessegueiros 'Chimarrita' e 'Maciel' sobre diferentes porta-enxertos e locais de cultivo.

Objetivou-se com o presente trabalho avaliar a influência dos porta-enxertos no que se refere ao crescimento vegetativo e desenvolvimento dos pessegueiro 'Chimarrita' e 'Maciel' em três locais de cultivo. O experimento foi desenvolvido em três locais de cultivo: 1 (Embrapa Uva e Vinho), 2 (EEA UFRGS) e 3 (CAP UFPel), em três anos. As cultivares de pessegueiro utilizadas foram: 'Chimarrita' e 'Maciel' enxertadas sobre seis porta-enxertos ('Aldrighi', 'Capdeboscq', 'Flordaguard', 'Nemaguard', 'Okinawa' e Umezeiro), no espaçamento 1,5 X 5,0m e conduzidas no sistema em ?V?. Foram avaliados: volume de copa, diâmetro de tronco, massa fresca da poda, produção por planta acumulada, comprimento, espessura, gemas floríferas e densidade florífera do ramo produtivo. Também foi avaliado de forma visual o ponto de enxertia. O porta-enxerto Umezeiro induziu menor vigor nos três locais de cultivo estudados e na média dos três anos. Ele pode ser indicado para utilização sob 'Maciel' nas condições edafoclimáticas do local 3. No local 1 o porta-enxerto, 'Nemaguard' possui alto vigor e maior produção acumulada, sendo o mais indicado. Já para o local 2, os porta-enxertos 'Capdeboscq', 'Okinawa' e 'Flordaguard' são os mais indicados. Os porta-enxertos afetam as características de crescimento e desenvolvimento das cultivares 'Chimarrita' e 'Maciel', o vigor destas é menor sobre o portaenxerto Umezeiro nos três locais de cultivo. Todos os portaenxertos podem ser indicados para os três locais de cultivo, com exceção do Umezeiro, que somente pode ser indicado em combinação com a cultivar 'Maciel' no local 3

Respiratory Inductance Plethysmography to Assess Fatigability during Repetitive Work

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COVID-19 in a Pediatric Cohort—Retrospective Review of Chest Computer Tomography Findings

Background: Radiological features of the novel 2019 coronavirus disease (COVID-19) have been mainly described in adults. Available literature states that imaging findings in children are similar but less pronounced. The aim of this study is to describe and illustrate the chest computer tomography (CT) features of pediatric COVID-19. Results: This retrospective study was based on the review of all the chest CTs performed in pediatric patients with confirmed COVID-19 disease between March 8th and May 26th 2020 (n = 24). The presence of comorbidities and coinfection was assessed, as well as timing of CT examination in relation to the onset of symptoms. CT findings were categorized as typical, indeterminate, atypical, and negative for COVID-19 according to International Expert Consensus Statement on Chest Imaging in Pediatric COVID-19 Patient Management. This study found that CT findings were abnormal in 17 (71%) patients, with 5 (21%), 9 (38%), and 3 (13%) patients considered to have typical, indeterminate, and atypical findings, respectively. The most common CT patterns were multiple ground-glass opacities (58%), followed by consolidations (50%). Six patients showed predominantly peripheral distribution of parenchymal abnormalities. A halo sign was identified in 3 patients and a perilobular pattern was identified in one of the cases with typical findings. Conclusions: Chest CT findings in children infected with SARS-CoV-2 can be subtle or absent. Besides recognizing typical findings, radiologists should be able to identify features that favor different or concomitant diagnosis.info:eu-repo/semantics/publishedVersio

A multicenter validation of an endoscopic classification with narrow band imaging for gastric precancerous and cancerous lesions

BACKGROUND AND STUDY AIM: The reliability and external validity of narrow band imaging (NBI) in the stomach have not been described consistently. The aim of the current study was to describe and estimate the accuracy and reliability of a simplified classification system for NBI in the diagnosis of gastric lesions. METHODS: Consecutive patients undergoing NBI endoscopy at two reference centers (n=85, 33% with dysplasia) were included in two studies. In total, 224 different areas were biopsied and recorded onto video. In the derivation study, previously described NBI features were analyzed in order to develop a simplified classification. In the validation study the accuracy and reliability of this classification were estimated among three groups of endoscopists with different levels of expertise in NBI. .RESULTS: The reliability/accuracy results from the derivation study allowed the creation of a simplified NBI classification. In the validation study, "regular vessels with circular mucosa" (pattern A) was associated with normal histology (accuracy 83%; 95% confidence interval [CI] 75?%-90%); "tubulo-villous mucosa" (pattern B) was associated with intestinal metaplasia (accuracy 84%; 95CI 77%-91%; positive likelihood ratio [LR+]=4.75); and "irregular vessels and mucosa" (pattern C) was associated with dysplasia (accuracy 95%; 95CI 90%-99%; LR+=44.33). The reproducibility of these patterns was high (k=0.62). "Light-blue crest" was moderately reliable (k=0.49) but specific (87%) for intestinal metaplasia. A variable vascular density (additional pattern+) was the best feature for Helicobacter pylori gastritis (accuracy 70%; 95CI 59%-80%) but showed only fair reliability (k=0.38). Non-experienced endoscopists presented lower agreement (k=0.6 vs. k=0.75) and accuracy (74% vs. 86%) than international experts/experienced endoscopists. CONCLUSION: A simplified NBI classification is accurate and reliable for the diagnosis of intestinal metaplasia and dysplasia. The classification should be further assessed and validated on a per-patient assessment of NBI, and by comparing NBI with other imaging technologies.This study was supported by a grant for medical investigation from the Portuguese Digestive Endoscopy Society (SPED 2009 Investigation Grant)

Planeamento do treino de combate em ambiente urbano, utilizando realidade virtual e aumentada

Urban areas are increasingly the predominant combat scenario and pose great difficulties to military commanders due to their complexity, presence of civilians, unpredictability and difficulty of communication. The infrastructures of the Centre for Combat Training in Urban Environments of the School of Arms, of the Portuguese Army in Mafra, Portugal, are well suited for training of combat planning of small combat units, from platoon up to company level, with a building campus called "Aldeia Camões", a command and control room and a shooting range simulator, suitable for the use of national and international military and security forces. This is the appropriate place for development and testing of technologies that can increase training capabilities in the planning and execution of military operations in urban areas. This article presents the results obtained with a solution that uses Virtual and Augmented Reality technologies to support Planning of Combat Training in Urban Areas in the mentioned "Aldeia Camões" campus. This solution adopts the paradigm of the "virtual sandbox", which, in analogy with its physical version, allows both the classic visualization of the ground plan, its urban elements and forces in presence, as well as the switching for an exploration of the campus within a 3D virtual environment, in a first-person mode, supporting also annotations in both modes and several other tools to support the planning of training of military operations in urban environments.info:eu-repo/semantics/acceptedVersio

Biofortified Diets Containing Algae and Selenised Yeast: Effects on Growth Performance, Nutrient Utilization, and Tissue Composition of Gilthead Seabream (Sparus aurata)

Efforts have been made to find natural, highly nutritious alternatives to replace fish meal (FM) and fish oil (FO), which can simultaneously promote fish health and improve the nutritional quality of filets for human consumption. This study evaluated the impact of biofortified diets containing microalgae (as replacement for FM and FO), macroalgae (as natural source of iodine) and selenised yeast (organic source of selenium) on gilthead seabream growth, nutrient utilization, tissue composition and gene expression. A control diet (CTRL) with 15% FM and 5.5% FO was compared with three experimental diets (AD1, AD2, and AD3), where a microalgae blend (Chlorella sp., Tetraselmis sp., and DHA-rich Schizochytrium sp.) replaced 33% of FM. Diet AD1 contained 20% less FO. Diets were supplemented with Laminaria digitata (0.4% AD1 and AD2; 0.8% AD3) and selenised yeast (0.02% AD1 and AD2; 0.04% AD3). After feeding the experimental diets for 12 weeks, growth was similar in fish fed AD1, AD2, and CTRL, indicating that microalgae meal can partially replace both FM and FO in diets for seabream. But AD3 suppressed fish growth, suggesting that L. digitata and selenised yeast supplementation should be kept under 0.8 and 0.04%, respectively. Despite lower lipid intake and decreased PUFAs bioavailability in fish fed AD3, compared to CTRL, hepatic elovl5 was upregulated resulting in a significant increase of muscle EPA + DHA. Indeed, filets of fish fed AD2 and AD3 provided the highest EPA + DHA contents (0.7 g 100 g–1), that are well above the minimum recommended values for human consumption. Fish consuming the AD diets had a higher retention and gain of selenium, while iodine gain remained similar among diets. Upregulation of selenoproteins (gpx1, selk, and dio2) was observed in liver of fish fed AD1, but diets had limited impact on fish antioxidant status. Overall, results indicate that the tested microalgae are good sources of protein and lipids, with their LC-PUFAs being effectively accumulated in seabream muscle. Selenised yeast is a good fortification vehicle to increase selenium levels in fish, but efforts should be placed to find new strategies to fortify fish in iodineThis work has received funding from the European Union’s Horizon 2020 Research and Innovation Programe under Grant Agreement No. 773400 (SEAFOODTOMORROW) and from the project ATLANTIDA (ref. NORTE-01-0145-FEDER-000040), supported by the Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement and through the European Regional Development Fund (ERDF). This work received financial support from REQUIMTE/LAQV national funds (FCT) through project UID/QUI/50006/2019. LV acknowledges national funds provided by FCT to CIIMAR (UIDB/04423/2020 and UIDP/04423/2020), PP-F acknowledges MAR2020 national funds provided to IPMA (DIVERISAQUA project - 16-02-01-FEAM-66) and MF acknowledges FCT for the grant SFRH/BD/144843/2019.info:eu-repo/semantics/publishedVersio

A Randomized Double-Blind Study Comparing the Efficacy and Safety of Orlistat Versus Placebo in Obese Patients with Mild to Moderate Hypercholesterolemia

INTRODUCTION: Obesity is a chronic disease and a serious health problem that leads to increased prevalence of diabetes, hypertension, dyslipidemia and gallbladder disease. OBJECTIVE: To evaluate the efficacy of orlistat for weight loss and improved lipid profile compared to placebo in obese patients with hypercholesterolemia, treated over a period of 6 months. METHODOLOGY: In a 6-month, multicenter (10 centers in Portugal), double-blind, parallel, placebo-controlled study, 166 patients, aged 18-65 years, body mass index (BMI) > or = 27 kg/m2, LDL cholesterol > 155 mg/dl, were randomized to a reduced calorie diet (600 kcal/day deficit) plus orlistat three times a day or placebo. Exclusion criteria included triglycerides > 400 mg/dl, severe cardiovascular disease, uncontrolled hypertension, type 1 or 2 diabetes under pharmacological treatment, and gastrointestinal or pancreatic disease. RESULTS: The mean difference in weight from baseline was 5.9% (5.6 kg) in the orlistat group vs. 2.3% (2.2 kg) in the placebo group. In the orlistat group 49% of patients achieved 5-10% weight loss and 8.8% achieved > 10%. The orlistat group showed a significant reduction in total and LDL cholesterol, with similar changes for HDL in both treatment groups. The frequency of gastrointestinal adverse events was slightly higher in the orlistat group than in the placebo group, leading to discontinuation in 7 patients. CONCLUSION: Treatment with orlistat plus a reduced calorie diet for 6 months achieved significant reductions in weight, BMI and lipid parameters

Será a obesidade um pesadelo na transplantação renal?

info:eu-repo/semantics/publishedVersio

LOCUS (LOng Covid–Understanding Symptoms, events and use of services in Portugal): A three-component study protocol

Approximately 10% of patients experience symptoms of Post COVID-19 Condition (PCC) after a SARS-CoV-2 infection. Akin acute COVID-19, PCC may impact a multitude of organs and systems, such as the cardiovascular, respiratory, musculoskeletal, and neurological systems. The frequency and associated risk factors of PCC are still unclear among both community and hospital settings in individuals with a history of COVID-19. The LOCUS study was designed to clarify the PCC's burden and associated risk factors. LOCUS is a multi-component study that encompasses three complementary building blocks. The "Cardiovascular and respiratory events following COVID-19" component is set to estimate the incidence of cardiovascular and respiratory events after COVID-19 in eight Portuguese hospitals via electronic health records consultation. The "Physical and mental symptoms following COVID-19" component aims to address the community prevalence of self-reported PCC symptoms through a questionnaire-based approach. Finally, the "Treating and living with Post COVID-19 Condition" component will employ semi-structured interviews and focus groups to characterise reported experiences of using or working in healthcare and community services for the treatment of PCC symptoms. This multi-component study represents an innovative approach to exploring the health consequences of PCC. Its results are expected to provide a key contribution to the optimisation of healthcare services design.info:eu-repo/semantics/publishedVersio