Comment on Ricci Collineations of Static Spherically Symmetric Spacetimes

We present a counter example to a theorem given by Amir {\em et al.} J. Math. Phys. {\bf 35}, 3005 (1994). We also comment on a misleading statements of the same reference.Comment: 4 pages,LaTex fil

Constraining models for the origin of ultra-high-energy cosmic rays with a novel combined analysis of arrival directions, spectrum, and composition data measured at the Pierre Auger Observatory

The combined fit of the measured energy spectrum and shower maximum depth distributions of ultra-high-energy cosmic rays is known to constrain the parameters of astrophysical models with homogeneous source distributions. Studies of the distribution of the cosmic-ray arrival directions show a better agreement with models in which a fraction of the flux is non-isotropic and associated with the nearby radio galaxy Centaurus A or with catalogs such as that of starburst galaxies. Here, we present a novel combination of both analyses by a simultaneous fit of arrival directions, energy spectrum, and composition data measured at the Pierre Auger Observatory. The model takes into account a rigidity-dependent magnetic field blurring and an energy-dependent evolution of the catalog contribution shaped by interactions during propagation. We find that a model containing a flux contribution from the starburst galaxy catalog of around 20% at 40 EeV with a magnetic field blurring of around 20° for a rigidity of 10 EV provides a fair simultaneous description of all three observables. The starburst galaxy model is favored with a significance of 4.5σ (considering experimental systematic effects) compared to a reference model with only homogeneously distributed background sources. By investigating a scenario with Centaurus A as a single source in combination with the homogeneous background, we confirm that this region of the sky provides the dominant contribution to the observed anisotropy signal. Models containing a catalog of jetted active galactic nuclei whose flux scales with the γ-ray emission are, however, disfavored as they cannot adequately describe the measured arrival directions

Demonstrating Agreement between Radio and Fluorescence Measurements of the Depth of Maximum of Extensive Air Showers at the Pierre Auger Observatory

We show, for the first time, radio measurements of the depth of shower maximum (Xmax) of air showers induced by cosmic rays that are compared to measurements of the established fluorescence method at the same location. Using measurements at the Pierre Auger Observatory we show full compatibility between our radio and the previously published fluorescence dataset, and between a subset of air showers observed simultaneously with both radio and fluorescence techniques, a measurement setup unique to the Pierre Auger Observatory. Furthermore, we show radio Xmax resolution as a function of energy and demonstrate the ability to make competitive high-resolution Xmax measurements with even a sparse radio array. With this, we show that the radio technique is capable of cosmic-ray mass composition studies, both at Auger and at other experiments

Radio measurements of the depth of air-shower maximum at the Pierre Auger Observatory

The Auger Engineering Radio Array (AERA), part of the Pierre Auger Observatory, is currently the largest array of radio antenna stations deployed for the detection of cosmic rays, spanning an area of 17 km2 with 153 radio stations. It detects the radio emission of extensive air showers produced by cosmic rays in the 30-80 MHz band. Here, we report the AERA measurements of the depth of the shower maximum (Xmax), a probe for mass composition, at cosmic-ray energies between 1017.5 and 1018.8 eV, which show agreement with earlier measurements with the fluorescence technique at the Pierre Auger Observatory. We show advancements in the method for radio Xmax reconstruction by comparison to dedicated sets of CORSIKA/COREAS air-shower simulations, including steps of reconstruction-bias identification and correction, which is of particular importance for irregular or sparse radio arrays. Using the largest set of radio air-shower measurements to date, we show the radio Xmaxresolution as a function of energy, reaching a resolution better than 15 g cm-2 at the highest energies, demonstrating that radio Xmax measurements are competitive with the established high-precision fluorescence technique. In addition, we developed a procedure for performing an extensive data-driven study of systematic uncertainties, including the effects of acceptance bias, reconstruction bias, and the investigation of possible residual biases. These results have been cross-checked with air showers measured independently with both the radio and fluorescence techniques, a setup unique to the Pierre Auger Observatory

Constraints on metastable superheavy dark matter coupled to sterile neutrinos with the Pierre Auger Observatory

Dark matter particles could be superheavy, provided their lifetime is much longer than the age of the Universe. Using the sensitivity of the Pierre Auger Observatory to ultrahigh energy neutrinos and photons, we constrain a specific extension of the Standard Model of particle physics that meets the lifetime requirement for a superheavy particle by coupling it to a sector of ultralight sterile neutrinos. Our results show that, for a typical dark coupling constant of 0.1, the mixing angle θm between active and sterile neutrinos must satisfy, roughly, θm ≲ 1.5 × 10−6(M X =10 9 GeV)−2 for a mass M X of the dark-matter particle between 108 GeV and 10 11 GeV

AugerPrime surface detector electronics

Operating since 2004, the Pierre Auger Observatory has led to major advances in our understanding of the ultra-high-energy cosmic rays. The latest findings have revealed new insights that led to the upgrade of the Observatory, with the primary goal of obtaining information on the primary mass of the most energetic cosmic rays on a shower-by-shower basis. In the framework of the upgrade, called AugerPrime, the 1660 water-Cherenkov detectors of the surface array are equipped with plastic scintillators and radio antennas, allowing us to enhance the composition sensitivity. To accommodate new detectors and to increase experimental capabilities, the electronics is also upgraded. This includes better timing with up-to-date GPS receivers, higher sampling frequency, increased dynamic range, and more powerful local processing of the data. In this paper, the design characteristics of the new electronics and the enhanced dynamic range will be described. The manufacturing and test processes will be outlined and the test results will be discussed. The calibration of the SD detector and various performance parameters obtained from the analysis of thefirst commissioning data will also be presented

Search for subsolar-mass black hole binaries in the second part of Advanced LIGO’s and Advanced Virgo’s third observing run

We describe a search for gravitational waves from compact binaries with at least one component with mass 0.2 M⊙–1.0 M⊙ and mass ratio q ≥ 0.1 in Advanced LIGO and Advanced Virgo data collected between 1 November 2019, 15:00 UTC and 27 March 2020, 17:00 UTC. No signals were detected. The most significant candidate has a false alarm rate of 0.2yr−1 ⁠. We estimate the sensitivity of our search over the entirety of Advanced LIGO’s and Advanced Virgo’s third observing run, and present the most stringent limits to date on the merger rate of binary black holes with at least one subsolar-mass component. We use the upper limits to constrain two fiducial scenarios that could produce subsolar-mass black holes: primordial black holes (PBH) and a model of dissipative dark matter. The PBH model uses recent prescriptions for the merger rate of PBH binaries that include a rate suppression factor to effectively account for PBH early binary disruptions. If the PBHs are monochromatically distributed, we can exclude a dark matter fraction in PBHs fPBH ≳ 0.6 (at 90% confidence) in the probed subsolar-mass range. However, if we allow for broad PBH mass distributions we are unable to rule out fPBH = 1. For the dissipative model, where the dark matter has chemistry that allows a small fraction to cool and collapse into black holes, we find an upper bound fDBH < 10−5 on the fraction of atomic dark matter collapsed into black holes

Sesterterpenoids in marine and terrestrial organisms: a relational database

Sesterterpenoids (SSTPs) are pentaprenyl terpenoids derived from the linear precursor geranylfarnesyl diphosphate, which have been isolated from fungi, bacteria, lichens, plants, insects, and various marine invertebrates, especially sponges. To define a schema of knowledge organization on this topic, it was necessary to collect skills from various disciplines such as chemistry, botany, biology, ecology, pharmacology and others. This joint effort led to the definition of a rather detailed conceptual model which was then instantiated in a logical diagram to define the database used in this project [1]. This database contains all the basic concepts, starting with the name of the molecule, the chemical class, the organisms from which it was first extracted, potential bioactivity properties, and major extraction method procedures. Bibliographic references are stored for each passage of information. A public website has been created to visualize and consult the collected material, to share database maintenance activities among managers, and to provide automatic links with other accredited databases for easy and timely updating of the information. Literature covers the years 1918 to 2023 and includes about 2000 SSTPs, classified according to their structural complexity, from linear pentaprenyl to carbocyclic and heterocyclic scaffolds. Marine and terrestrial organismal sources are reported, and also, when possible, the synthetic origin of their SSTPs repertoire. A variety of bioactivities were described, ranging from cytotoxicity against human cancer cells and inhibition of pathogenic microbes, to anti-inflammatory, antiprotozoal, antitubercular and antifeedant activities and modulation of neurodegenerative processes, as well as activity in the treatment of metabolic diseases such as type II diabetes, hypercholesterolemia and obesity, and as immunosuppressive molecules

Isolation of Acacetin from <i>Calea urticifolia</i> with Inhibitory Properties against Human Monoamine Oxidase‑A and -B

<i>Calea urticifolia</i> (Asteraceae: Asteroideae) has long been used as a traditional medicine in El Salvador to treat arthritis and fever, among other illnesses. The chloroform extract of the leaves of <i>C. urticifolia</i> showed potent inhibition of recombinant human monoamine oxidases (MAO-A and -B). Further bioassay-guided fractionation led to the isolation of a flavonoid, acacetin, as the most prominent MAO inhibitory constituent, with IC₅₀ values of 121 and 49 nM for MAO-A and -B, respectively. The potency of MAO inhibition by acacetin was >5-fold higher for MAO-A (0.121 μM vs 0.640 μM) and >22-fold higher for MAO-B (0.049 μM vs 1.12 μM) as compared to apigenin, the closest flavone structural analogue. Interaction and binding characteristics of acacetin with MAO-A and -B were determined by enzyme-kinetic assays, enzyme–inhibitor complex binding, equilibrium–dialysis dissociation analyses, and computation analysis. Follow-up studies showed reversible binding of acacetin with human MAO-A and -B, resulting in competitive inhibition. Acacetin showed more preference toward MAO-B than to MAO-A, suggesting its potential for eliciting selective pharmacological effects that might be useful in the treatment of neurological and psychiatric disorders. In addition, the binding modes of acacetin at the enzymatic site of MAO-A and -B were predicted through molecular modeling algorithms, illustrating the high importance of ligand interaction with negative and positive free energy regions of the enzyme active site