Bullies in the Block Area: The Early Childhood Origins of Mean Behavior

Bullying can pose a serious threat to children's immediate and long-term health and well-being, and can have profound impacts on all children involved in bullying behaviors, whether as the one bullying others, the one being bullied, or the one witnessing bullying. At least some of the roots of bullying behaviors, and conversely the roots of positive pro-social skills, can likely be found in adverse and positive experiences during early childhood, yet the research literature on these connections is limited. The early childhood field lacks a coherent, theoretical model that identifies the factors contributing to "mean" or aggressive behavior in young children, and establishes the developmental link between this early behavior and later bullying behavior. This white paper summarizes the literature on seven key hypotheses about the roots of bullying behavior in early childhood experiences

Invasion of Plant Communities

Due to numerous human activities, organisms have been transported and either accidentally or deliberately introduced all around the globe. Biological invasions are now considered to be one of the main drivers of global change because many invasive plants have severe ecological, economic, and health consequences. Thus, there is an ever-growing need to better understand invasions to determine how specific plant species are able to establish in communities and, in many cases, expand their range. Here, we describe the invasion process and how it contributes to the invasion of plant communities. We present an invasion-factor framework (IFF) model that uses three factors (climate dynamics, ecosystem resistance, and invader fitness) to explain how each plays a role in the introduction of plants and their ultimate failure or success (i.e., becoming invasive). The invasion of plant communities starts with the uptake of propagules from the native range, followed by their transport to and release into a new territory, where they become established and can spread or expand. Propagule pressure, prior adaptation, anthropogenically induced adaptation to invade, and post-introduction evolution are several theories that have been posed to explain the establishment of invasive plants. Further, traits of invasive plants, either before (existing) or after (developed) introduction, provide a mechanistic understanding with direct ties to the three factors of the IFF. The IFF is a general guide with which to study the invasion process based on specific factors for individual invaders and their target communities. The IFF combines (a) climatic dynamics, analogous to environmental filters; (b) ecosystem resistance, which prevents invasive plants from becoming established even if they are able to overcome the climate factor; and (c) invader fitness, relating to the genetic diversity of invasive plants, which allows them to become established after overcoming climate and ecosystem resistance factors. Case studies from the literature provide examples of research investigating each of the three factors of the IFF, but none exist that describe all the factors at once for any given invasive plant species. The application of the IFF for management is most appropriate once an invasive plant has become established, as preventative measures before this point rely only on accurate identification (detection) and removal (response). The IFF model should be considered as a tool to establish research priorities and identify components in the invasion process and inform restoration efforts. We advocate that the IFF should be integrated into management practices to help in the decision-making process that contributes to more effective practices that reduce the occurrence and impacts of invasive plants in a range of communities

Measuring Mental Health Literacy: Development of the Mental Health Awareness and Advocacy Assessment Tool

Background: Mental health literacy programs are a common community-based approach used to address the prevention of mental health issues on college campuses. Current assessment strategies used to evaluate the effectiveness of these programs often lack strong theoretical rational and psychometric rigor. Purpose: The purpose of this study was twofold. First, based upon extant literature, theory, and standard clinical practice, we propose a process-based model of mental health literacy that includes three macro factors—identifying mental health issues, locating empirically based resources, and responding to mental health issues—and three micro processes of how they unfold—acquiring knowledge, building self-efficacy, and applying skills (behavior). The second aim was to test the psychometric properties of a new tool created to evaluate this process-based model—the Mental Health Awareness and Advocacy Assessment Tool (MHAA-AT). Setting: Not applicable. Intervention: Not applicable. Research Design: A national sample of 296 college attending participants were recruited from Amazon’s Mechanical Turk. Participants responded to a demographic questionnaire and the newly developed MHAA-AT. Psychometric properties were examined through item response theory, exploratory factor analyses, and bivariate correlations. Findings: Results suggest the MHAA-AT is a sound measure and demonstrates appropriate item, person, and trait characteristics on declarative knowledge items, and single factor structures on self-efficacy and behavior items with moderate to high reliability and validity. While additional testing is need among other samples, results suggest that the MHAA-AT is a quality assessment tool. Keywords: College students; mental health literacy; item response theory; measuremen

Altered brain mechanisms of emotion processing in pre-manifest Huntington's disease

Huntington's disease is an inherited neurodegenerative disease that causes motor, cognitive and psychiatric impairment, including an early decline in ability to recognize emotional states in others. The pathophysiology underlying the earliest manifestations of the disease is not fully understood; the objective of our study was to clarify this. We used functional magnetic resonance imaging to investigate changes in brain mechanisms of emotion recognition in pre-manifest carriers of the abnormal Huntington's disease gene (subjects with pre-manifest Huntington's disease): 16 subjects with pre-manifest Huntington's disease and 14 control subjects underwent 1.5 tesla magnetic resonance scanning while viewing pictures of facial expressions from the Ekman and Friesen series. Disgust, anger and happiness were chosen as emotions of interest. Disgust is the emotion in which recognition deficits have most commonly been detected in Huntington's disease; anger is the emotion in which impaired recognition was detected in the largest behavioural study of emotion recognition in pre-manifest Huntington's disease to date; and happiness is a positive emotion to contrast with disgust and anger. Ekman facial expressions were also used to quantify emotion recognition accuracy outside the scanner and structural magnetic resonance imaging with voxel-based morphometry was used to assess the relationship between emotion recognition accuracy and regional grey matter volume. Emotion processing in pre-manifest Huntington's disease was associated with reduced neural activity for all three emotions in partially separable functional networks. Furthermore, the Huntington's disease-associated modulation of disgust and happiness processing was negatively correlated with genetic markers of pre-manifest disease progression in distributed, largely extrastriatal networks. The modulated disgust network included insulae, cingulate cortices, pre- and postcentral gyri, precunei, cunei, bilateral putamena, right pallidum, right thalamus, cerebellum, middle frontal, middle occipital, right superior and left inferior temporal gyri, and left superior parietal lobule. The modulated happiness network included postcentral gyri, left caudate, right cingulate cortex, right superior and inferior parietal lobules, and right superior frontal, middle temporal, middle occipital and precentral gyri. These effects were not driven merely by striatal dysfunction. We did not find equivalent associations between brain structure and emotion recognition, and the pre-manifest Huntington's disease cohort did not have a behavioural deficit in out-of-scanner emotion recognition relative to controls. In addition, we found increased neural activity in the pre-manifest subjects in response to all three emotions in frontal regions, predominantly in the middle frontal gyri. Overall, these findings suggest that pathophysiological effects of Huntington's disease may precede the development of overt clinical symptoms and detectable cerebral atroph

Ion channels in control of pancreatic stellate cell migration

Pancreatic stellate cells (PSCs) play a critical role in the progression of pancreatic ductal adenocarcinoma (PDAC). Once activated, PSCs support proliferation and metastasis of carcinoma cells. PSCs even co-metastasise with carcinoma cells. This requires the ability of PSCs to migrate. In recent years, it has been established that almost all “hallmarks of cancer” such as proliferation or migration/invasion also rely on the expression and function of ion channels. So far, there is only very limited information about the function of ion channels in PSCs. Yet, there is growing evidence that ion channels in stromal cells also contribute to tumor progression. Here we investigated the function of K(Ca)3.1 channels in PSCs. K(Ca)3.1 channels are also found in many tumor cells of different origin. We revealed the functional expression of K(Ca)3.1 channels by means of Western blot, immunofluorescence and patch clamp analysis. The impact of K(Ca)3.1 channel activity on PSC function was determined with live-cell imaging and by measuring the intracellular Ca2(+) concentration ([Ca(2+)](i)). K(Ca)3.1 channel blockade or knockout prevents the stimulation of PSC migration and chemotaxis by reducing the [Ca(2+)](i) and calpain activity. K(Ca)3.1 channels functionally cooperate with TRPC3 channels that are upregulated in PDAC stroma. Knockdown of TRPC3 channels largely abolishes the impact of K(Ca)3.1 channels on PSC migration. In summary, our results clearly show that ion channels are crucial players in PSC physiology and pathophysiology

Placemaking in Metro East Springfield - Creating a Landscape Framework

PLACEMAKING IN METRO EAST SPRINGFIELD - Creating a Landscape Framework Placemaking in Metro East Springfield – Creating a Landscape Framework provides strategies to use the landscape as a framework for rebuilding community in a downtown urban area that has “good bones” but has been neglected and overlooked for decades. A catalyst for the development of project area is the recent acquisition of the historical 1916 Willys Overland building through a developer. The Graduate Urban Design Studio 2018 developed five proposals for urban revitalization in the area that are centered on the landscape. The programming of the proposals was developed in collaboration with neighborhood representatives and stakeholders of the area. The public response was very positive and the project got recognized in the local press and media. The Landscape Framework is interwoven with cultural activities such as public art and education, new opportunities for small neighborhood commerce, future employment and possibilities for new housing. The Landscape Framework will bring expand urban greening and will reduce heat island effects to reduce the impact of climate change. The presented Landscape Framework will guide the future of the area as overlapping and simultaneous measures. They encompass: Tangible tactile interventions on streets, facades and underutilized lots that change the perception of the landscape at low cost but are highly effective. New parks that create areas for recreation and contemplation. Greenway promenades connect to shorten long blocks and create a network to the neighboring residential areas. Establishment of urban agriculture activities to build community, provide food security and education. Collaboration with existing organizations in Springfield that are actively involved with urban agriculture: Gardening the Community (GTC) Springfield, Wellspring Harvest first commercial hydroponic greenhouse, UMass Extension and UMass Permaculture, Springfield Technical Community College (STCC). Walkable streets through extensive street tree plantings, widening of sidewalks, adding bicycle lanes and introducing shared multi-functional streets for community events. Stormwater Management through bioswales along streets, green roofs, larger infiltration areas in new parks and porous pavement. Promotion of alternative stormwater management through education and artistic interventions. People want to connect culturally and socially. Creating a sense of place, common ownership, and connectivity are a vital part of a sustainable community. This includes: Complimentary cultural, art, craft and education at new Maker-Spaces. Daycare Center and other childcare services. Outdoor pop-up business opportunities for food vendors such as food carts and trucks. Indoor pop-up business opportunities in abandoned or underutilized buildings. Adaptive reuse of existing architecture and infill. Diversification of housing market with inclusion of market-rate housing to create a more balanced economy. Legal framework through zoning changes and permitting that supports small businesses, reduces bureaucratic burdens and secures public open green space

West Nile Virus Detection in American Crows

A dipstick immunochromatographic assay used for West Nile virus (WNV) detection in mosquitoes was investigated for application to testing of fecal, saliva, and tissue samples from dead American Crows (Corvus brachyrhynchos). Results suggest that VecTest may be an efficient method for WNV detection in field-collected, dead American Crows, although confirmation of results and further investigation are warranted

West Nile Virus Detection in American Crows

A dipstick immunochromatographic assay used for West Nile virus (WNV) detection in mosquitoes was investigated for application to testing of fecal, saliva, and tissue samples from dead American Crows (Corvus brachyrhynchos). Results suggest that VecTest may be an efficient method for WNV detection in field-collected, dead American Crows, although confirmation of results and further investigation are warranted