Correcting the Shrinkage Effects of Formalin Fixation and Tissue Processing for Renal Tumors: toward Standardization of Pathological Reporting of Tumor Size

Given the importance of correctly staging renal cell carcinomas, specific guidelines should be in place for tumor size measurement. While a standard means of renal tumor measurement has not been established, intuitively, tumor size should be based on fresh measurements. We sought to assess the accuracy of postfixation and microscopic measurements of renal tumor size, as compared to fresh measurements and radiographic size. Thirty-four nephrectomy cases performed by a single surgeon were prospectively measured at different time points. The study cases included 23 clear cell renal cell carcinomas, 6 papillary renal cell carcinomas, and 5 other renal tumors. Radiologic tumors were 12.1% larger in diameter than fresh tumors (P<0.01). Furthermore, fresh specimens were 4.6% larger than formalin-fixed specimens (P<0.01), and postfixation measurements were 7.1% greater than microscopic measurements (P<0.01). The overall mean percentage of shrinkage between fresh and histological specimens was 11.4% (P<0.01). Histological processing would cause a tumor stage shift from pT1b to pT1a for two tumors in this study. The shrinkage effects of formalin fixation and histological processing may result in understaging of renal cell carcinomas. The shrinkage factor should be considered when reporting tumor size

Solitary fibrous tumour of the genitourinary tract: a clinicopathological study of 11 cases and their association with the NAB2-STAT6 fusion gene

Aims To characterise clinicopathological features and clinical outcomes of the genitourinary tract solitary fibrous tumours, incorporating NAB2-STAT6 gene fusion status. Methods The presence of the molecular hallmark NAB2-STAT6 gene fusion and for the defining fusion partner product STAT6 was assessed in 11 cases of the genitourinary tract solitary fibrous tumours. NAB2-STAT6 gene fusion analysis was performed using a break-apart fluorescence in situ hybridisation (FISH) probe using a probe cocktail with Bacterial artificial chromosome (BAC) clones for STAT6 and NAB2. Results Eleven solitary fibrous tumours were diagnosed in eight male patients and three female patients with a mean age of 46 years (range: 11–64 years). Four of the tumours had malignant histological features, and three were considered moderate risk for metastasis. With a mean follow-up time of 61 months, 1 recurred locally and 2 presented at distant metastatic sites. Using a break-apart FISH probe cocktail, we found the NAB2-STAT6 gene fusion and nuclear STAT6 expression in 58% and 91% of cases, respectively. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between malignant histological features or subsequent clinical outcomes in the genitourinary solitary fibrous tumours. Conclusions A subset of solitary fibrous tumours of the genitourinary tract behaved aggressively. Using a break-apart FISH probe cocktail, we found the NAB2-STAT6 gene fusion in 64% of cases. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between low-risk or high-risk tumours and subsequent clinical outcomes

Rencontre avec Aurélia Cohendy autour de l'exposition "Quand la peinture était dans les livres"

L’association Artes Novae a le plaisir de vous inviter à une rencontre avec Aurélia Cohendy autour de l’exposition « Quand la peinture était dans les livres » dont elle a assuré le commissariat avec Magali Vène et qui est présentée à la Bibliothèque d’étude et du patrimoine de Toulouse du 17 mars au 16 juin 2018. La rencontre aura lieu le mardi 5 juin 2018 de 18h30 à 19h30 à l’INHA (2 rue Vivienne, 75002 Paris), Galerie Colbert, salle Demargne. Elle est ouverte à toute personne intéressée dan..

Artes Novae

Fondée en mars 2018, Artes Novae est l'association des jeunes chercheur(e)s en archéologie et histoire de l'art du Moyen Âge et de la Renaissance, actifs en Île-de-France. Son objectif est de fédérer des étudiant(e)s, doctorant(e)s et jeunes docteur(e)s intéressés par ces problématiques. À ce titre, nous organisons des ateliers de discussion entre jeunes chercheur(e)s autour de questions scientifiques et méthodologiques, des visites d'actualité (expositions, musées et chantiers) et des rencon..

Visite de l'exposition « Naissance de la sculpture gothique. Saint-Denis, Paris, Chartres (1135-1150) »

L'association Artes Novae organise une visite de l'exposition « Naissance de la sculpture gothique. Saint-Denis, Paris, Chartres, 1135-1150 » (10 octobre 2018-21 janvier 2019) conduite par Philippe Plagnieux, professeur en histoire de l'art médiéval (Université Paris I-Panthéon-Sorbonne, École nationale des chartes) et co-commissaire de l'exposition. Cette visite guidée aura lieu le jeudi 10 janvier à 15h au musée de Cluny. L'inscription, limitée à 20 personnes, est obligatoire à l'adresse ..