THE LIFE HISTORY AND DEVELOPMENT OF HYPOGLOSSUM RHIZOPHORUM (DELESSERIACEAE, RHODOPHYTA) IN CULTURE, A NEW DEEP-WATER SPECIES FROM THE CARIBBEAN 1

Hypoglossum rhizophorum sp. nov. is described from deep coral reef habitats on the southern insular shelf of Puerto Rico and the western insular shelf of Basse Terre, Guadeloupe, occurring from 21 to 85 m in depth. The new species is also known from a single shallow-water collection in Hawaii. Plants grow from a prostrate nonfoliose rhizome producing simple, delicate erect blades at regular intervals. Reproductive plants were not collected in the field; isolated plants, however, readily reproduced in culture demonstrating a typical “Polysiphonia - type” life history. Spermatangial sori form coalesced oblique bands which are interrupted by secondary cell rows. Tetrasporangia are produced from both lateral and transverse pericentral cells, adjacent second- and third-order cells as well as cortical cells .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65860/1/j.1529-8817.1988.tb04449.x.pd

<ORIGINAL ARTICLE>Characterization of a new coagulant enzyme isolated from Trimeresurus okinavensis (Himehabu snake) venom

A potent, proteinaceous inducer of coagulation factors, has been purified to homogeneity from Trimeresurus okinavensis (Himehabu snake) by ion exchange chromatography and molecular sieving. It has an apparent molecular weight of 28,000 and it specifically converts fibrinogen to fibrin through an enzymatic reaction. This activity was confirmed by a method using synthetic substrate S-2238, though the fraction from a DEAE sephacel column chromatography shows amidolytic activity of S-2251 and S-2366, which are commonly used to measure plasmin and activated protein C activity, respectively, as well as S-2238. This thrombin-like activity of the final product was not affect by the addition of heparin and AT-III. This enzyme also aggregates normal platelets. It is considered that this purified enzyme would be useful as a hemostatic agent or research reagent

鉄粉層内蔵ばね型アクチュエータの研究

A new spring type actuator is presented in which controls are possible by using usual control methods such as PID control. The actuator consists of a usual helical coil spring and a number of iron (ferrite) particle layers inside. The iron layers are made of silicon based adhesive material involving iron particles. The layers are pasted to the coil spring with a certain air gap between each layer. To achieve both extensive and compressive motions, a permanent magnet is attached to the top of the spring and electromagnet to the base, and the motion of the top of the actuator is controlled by electric currents in the coil of the electromagnet. Amethod of forming the actuator is presented, and its design formulae are presented. The present actuator works well under the control. Especially, the size is small in comparison with such as moving coil actuators, the work area is large enough, and the controlled accuracy is sufficient under the position- and vibration-control.学位記番号：工博甲33

IARSDE - Infra Estrutura de Armazenamento e Recuperação Segura de Documentos Eletrônicos: validade do documento eletrônico por tempo indeterminado

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Ciência da Computação.A proposta apresentada neste trabalho constitui-se de uma infra-estrutura de armazenamento e recuperação de documento eletrônicos, que garante a estes a retenção de seus atributos por tempo indeterminado. A infra-estrutura atualiza dinamicamente a tecnologia utilizada para conferir a assinatura digital e o selo de tempo. Para que isto seja possível, neste trabalho consta também uma proposta de software padrão de assinatura digital, o qual organiza o documento e suas informações de modo a garantir a Infra Estrutura de Armazenamento e Recuperação Segura de Documentos Eletrônicos - IARSDE os atributos necessários para o controle da renovação da tecnologia do documento

Renoprotective Action of a Matrix Metalloproteinase Inhibitor in Progressive Mesangioproliferative Nephritis

Background/Aim: Matrix metalloproteinases (MMPs) play pivotal roles in extracellular matrix turnover and are involved in chronic kidney disease. The renoprotective action of a synthetic MMP inhibitor, compound A, was investigated in chronic nephritis. Methods: Nephritis was induced by a single injection of anti-Thy1.1 antibody to unilaterally nephrectomized rats. The effects of compound A on proteinuria, blood urea nitrogen, and matrix-related gene expressions were evaluated. Collagen accumulation, as assessed by periodic acid-Schiff staining and hydroxyproline content, was determined. The integrity of glomerular epithelial cells and glomerular basement membrane was evaluated with desmin immunohistochemistry and electron microscopic detection of anionic charge sites, respectively. Results: Treatment with compound A notably attenuated proteinuria, ameliorated blood urea nitrogen, and prevented glomerulosclerosis. Gene upregulation of collagen and transforming growth factor β1 in the cortex was prevented in the treated animals. Glomerular epithelial cell injury was milder, and glomerular basement membrane anionic sites were protected with the treatment. Conclusion: A novel MMP inhibitor, compound A, exerts protective effects in progressive glomerulonephritis. Compound A ameliorates various aspects of renal injuries and may have therapeutic potential toward kidney diseases

低周波電流刺激による吃音発生抑制作用

われわれのこれまでの研究から、末梢における吃音症状発生の主体は、声帯レベルでの機能異常によるものの可能性が強いことが推測されている。本研究は、吃音発生時の声門レベルの異常に焦点をて、低周波干渉電流が吃音発生の抑制に関与するかを検討することを目的としている。低周波干渉電流刺激療法が、理学療法の分野では末梢神経の伝導抑制作用を示し、その作用を利用して消炎・鎮痛療法があることは広く認められている。また、低周波による神経刺激実験で50Hz以上の電流が鎮痙的作用があることも知られている。3例の成人吃音患者を対象としたが、発話時のBlockと、身体の随伴症状が最も著しかった1例を対象に、上肢に電極を装着して電流刺激をした場合と、咽頭に電極を装着して電流刺激をした場合と、電流を流さない状態とで、文章音読時の吃音症状出現頻度について検討した。電流刺激装置は日本メデックス社の低周波刺激装置を用いた。咽頭への電流刺激方法は、星状神経節ブロック施行時の要領で行い、50-60Hz、5-10mAの電流を流した。また、distraction効果についても検討した。その結果、咽頭への電流刺激が吃音症状軽減に有効であることが示唆された。 干渉低周波刺激電流は、声帯に物理的な刺激を加えるが、声帯の器質的な変化を惹起させることなく、繰り返し利用可能であるので、吃音者が吃音を予測した時に電流をを刺激するすることにより、吃音症状軽減効果が期待できる。This study evaluates the effectiveness of interferential current stimulation to decrease stuttering symptoms. Three patients with chronic stuttering participated in this study. Inferential current stimulation was tried on the most severe patient of the three. The subject received 2 trials of interferential current stimulation on his larynx, and 2 trials of interferential current stimulation to his arm, and two trials of no current stimulation to his larynx. Stuttering symptoms decreased only for inferential current stimulation to his larynx. It is concluded that for chronic stuttering patients inferential current stimulation to their larynxes will decrease severe chronic stuttering.研究課題/領域番号:08671957, 研究期間(年度):1996–1998出典：「低周波電流刺激による吃音発生抑制作用」研究成果報告書　課題番号08671957 (KAKEN：科学研究費助成事業データベース（国立情報学研究所）)　　　本文データは著者版報告書より作

Horizontal visual search in a large field by patients with unilateral spatial neglect

In this study, we investigated the horizontal visual search ability and pattern of horizontal visual search in a large space performed by patients with unilateral spatial neglect (USN). Subjects included nine patients with right hemisphere damage caused by cerebrovascular disease showing left USN, nine patients with right hemisphere damage but no USN, and six healthy individuals with no history of brain damage who were age-matched to the groups with brain right hemisphere damage. The number of visual search tasks accomplished was recorded in the first experiment. Neck rotation angle was continuously measured during the task and quantitative data of the measurements were collected. There was a strong correlation between the number of visual search tasks accomplished and the total Behavioral Inattention Test Conventional Subtest (BITC) score in subjects with right hemisphere damage. In both USN and control groups, the head position during the visual search task showed a balanced bell-shaped distribution from the central point on the field to the left and right sides. Our results indicate that compensatory strategies, including cervical rotation, may improve visual search capability and achieve balance on the neglected side. © 2012 Elsevier Ltd. All rights reserved.Thesis of Ken Nakatani / 中谷 謙 博士論文 金沢大学医薬保健学総合研究科（保健学専攻