Exposure to heavy metal contamination and probabilistic health risk assessment using Monte Carlo simulation: a study in the Southeast Iran

The rice contamination to heavy metals and its associated health risks have been less addressed in the southeast of Iran. In the present study, in the mentioned region, we assessed the concentration of nine elements in rice, and the health risk related to the measured elements was determined using the data which were gathered by a questionnaire. For this purpose, 36 samples of the 12 most widely consumed rice brands were collected. Using ICP-MS, the concentrations of Ni, Cr, Hg, Sr, Mn, Fe, Se, Ba, and Zn were measured in the studied samples as 0.599 ± 0.124, 0.483 ± 0.28, 0.0157 ± 0.005, 0.85 ± 1.307, 11.5 ± 1.97, 178.46 ± 67.27, 0.212 ± 0.083, 0.845 ± 0.62, and 8.416 ± 1.611 mg/kg, respectively. We found that, regarding the other studies, the levels of Ni, Cr, Hg, Fe, and Ba were higher. Besides, using 258 distributed questionnaires among citizens, the daily rice consumption was determined to be 295.66 ± 171.005 g/person/ day. Based on this consumption rate and Monto Carlo uncertainty simulation, Fe (0.741 ± 0.54 mg/kg/day) and Se (8.95E-04 ± 6.33E-04 mg/kg/day) showed the highest and lowest daily intake, respectively. Also, using Hazard Quotient (HQ), the non-carcinogenic risk effects of the surveyed elements were estimated. The obtained results of HQ revealed that Fe (2.48) and Mn (1.06) could pose non-carcinogenic health risks to consumers. Moreover, the calculated hazard Index showed that the overall health risk of the surveyed elements is in an unsafe range. © 2020, Springer Nature Switzerland AG

Association between colorectal cancer and Fusobacterium nucleatum and Bacteroides fragilis bacteria in Iranian patients: a preliminary study

Background and aim: Recent studies have proposed that commensal bacteria might be involved in the development and progression of gastrointestinal disorders such as colorectal cancer (CRC). Therefore, in this study, the relative abundance of Fusobacterium nucleatum, Bacteroides fragilis, Streptococcus bovis/gallolyticus, and Enteropathogenic Escherichia coli (EPEC) in CRC tissues, and their association with clinicopathologic characteristics of CRC was investigated in Iranian patients. Moreover, the role of these bacteria in the CRC-associated mutations including PIK3CA, KRAS, and BRAF was studied. Method: To these ends, the noted bacteria were quantified in paired tumors and normal tissue specimens of 30 CRC patients, by TaqMan quantitative Real-Time Polymerase Chain Reaction (qPCR). Next, possible correlations between clinicopathologic factors and mutations in PIK3CA, KRAS, and BRAF genes were analyzed. Results: In studied samples, B. fragilis was the most abundant bacteria that was detected in 66 and 60 of paired tumor and normal samples, respectively. Furthermore, 15 of the B. fragilis-positive patients were infected with Enterotoxigenic B. fragilis (ETBF) in both adenocarcinoma and matched adjacent normal samples. F. nucleatum was also identified in 23 of tumors and 13 of adjacent normal tissue samples. Moreover, the relative abundance of these bacteria determined by 2-�CT was significantly higher in CRC samples than in adjacent normal mucosa (p < 0.05). On the other hand, our findings indicated that S. gallolyticus and EPEC, compared to adjacent normal mucosa, were not prevalent in CRC tissues. Finally, our results revealed a correlation between F. nucleatum-positive patients and the KRAS mutation (p = 0.02), while analyses did not show any association between bacteria and mutation in PIK3CA and BRAF genes. Conclusion: The present study is the first report on the analysis of different bacteria in CRC tissue samples of Iranian patients. Our findings revealed that F. nucleatum and B. fragilis might be linked to CRC. However, any link between gut microbiome dysbiosis and CRC remains unknown. © 2021, The Author(s)

Stochastic exposure and health risk assessment of rice contamination to the heavy metals in the market of Iranshahr, Iran

An investigation of some heavy metals content in rice (Oryza sativa) and associated health risks was carried out for residents of Iranshahr city, Iran. Average daily rice consumption of the citizens and most widely used rice brands in the market of Iranshahr were determined using a questionnaire. Besides, the concentration of heavy metals in the gathered rice samples was measured by inductively coupled plasma mass spectrometry (ICP-MS). Monte Carlo uncertainty simulation was utilized in conducting exposure assessment and investigating the non-carcinogenic effects of the studied elements as well as the carcinogenic effect of As. Concentrations of As, Cd, Pb, Cu, Al, and Mo were 0.369 ± 0.094, 0.0337 ± 0.039, 0.123 ± 0.14, 3.095 ± 439.42, 39.6 ± 14.73, and 1.106 ± 0.133 mg kg�1, respectively. Al (0.18 ± 0.15 mg kg�1 d�1) and Cd (0.00015 ± 0.00034 mg kg�1 d�1) were the highest and lowest estimated daily intake, respectively. Except As (5.23 ± 4.01), the calculated hazard quotient for investigated elements showed no non-carcinogenic health risk. Besides, the simulation of the carcinogenic risk effect for As (2.37E-3) revealed that the ingestion of the studied rice brands would cause cancer risk due to lifetime consumption. Results show that consumption of rice in the Iranshahr city is a potential source of exposure to the studied elements. © 2018 Elsevier Lt

Stochastic exposure and health risk assessment of rice contamination to the heavy metals in the market of Iranshahr, Iran

An investigation of some heavy metals content in rice (Oryza sativa) and associated health risks was carried out for residents of Iranshahr city, Iran. Average daily rice consumption of the citizens and most widely used rice brands in the market of Iranshahr were determined using a questionnaire. Besides, the concentration of heavy metals in the gathered rice samples was measured by inductively coupled plasma mass spectrometry (ICP-MS). Monte Carlo uncertainty simulation was utilized in conducting exposure assessment and investigating the non-carcinogenic effects of the studied elements as well as the carcinogenic effect of As. Concentrations of As, Cd, Pb, Cu, Al, and Mo were 0.369 ± 0.094, 0.0337 ± 0.039, 0.123 ± 0.14, 3.095 ± 439.42, 39.6 ± 14.73, and 1.106 ± 0.133 mg kg�1, respectively. Al (0.18 ± 0.15 mg kg�1 d�1) and Cd (0.00015 ± 0.00034 mg kg�1 d�1) were the highest and lowest estimated daily intake, respectively. Except As (5.23 ± 4.01), the calculated hazard quotient for investigated elements showed no non-carcinogenic health risk. Besides, the simulation of the carcinogenic risk effect for As (2.37E-3) revealed that the ingestion of the studied rice brands would cause cancer risk due to lifetime consumption. Results show that consumption of rice in the Iranshahr city is a potential source of exposure to the studied elements. © 2018 Elsevier Lt

UV Activation of Persulfate for Removal of Penicillin G Antibiotics in Aqueous Solution

Penicillin G (PG) is one of the most widely consumed antibiotics around the world. Release of PG in environment may lead to contamination of water resources. The aim of the present work is to assess feasibility of applying UV-activated persulfate process in removal of PG from aquatic environments. The study examined the effect of pH (3–11), persulfate initial concentration (0.5–3 mM), reaction time (15–90 minutes), and initial concentration of PG (0.02–0.14 mM) on PG decomposition. Also, the pseudo-first-order kinetic model was used for kinetic analysis of PG removal. The results indicated that UV-activated persulfate process can effectively eliminate PG from water. The highest PG removal efficiency was obtained as 94.28% at pH 5, and the decomposition percentage was raised by increasing persulfate dose from 0.5 to 3 mM and the reaction time from 15 to 90 minutes. Besides, the removal efficiency decreased through increasing the initial concentration of PG. UV-activated persulfate process effectively decomposes PG and eliminates it from water

Quantitative and qualitative analysis of dental clinics waste in Zabol city, Iran

Dental clinics are one of the sources of waste production that are important due to producing infectious and potentially infectious waste, chemical and pharmaceutical waste, and toxic waste. Therefore, this study aimed to analyze dental clinics in Zabol quantitatively and qualitatively. This descriptive cross-sectional study was conducted in 2014 on waste produced in dental clinics in Zabol. Sampling of 25 dental clinics was performed three times per week. At the end of the working day, the samples were transferred to a suitable site and weighed carefully after separation of the components. Data were analyzed using descriptive statistics and Excel software. 5457 kg of waste is annually produced in the dental clinics of Zabol that the amount of infectious and potentially infectious waste, household-like waste, chemical and pharmaceutical waste, and toxic wastes are approximately 48.08, 43.75, 7.82 and 0.35%, respectively. Given that proper management of waste produced is not performed in dental clinics in Zabol, special attention to waste produced in this sector through programs of reduction in source, separation and recycling can reduce the waste volume significantly. Keywords: Dentistry waste, Dental clinics, Waste composition, Infectious waste, Toxic wast

Stochastic exposure and health risk assessment of rice contamination to the heavy metals in the market of Iranshahr, Iran

An investigation of some heavy metals content in rice (Oryza sativa) and associated health risks was carried out for residents of Iranshahr city, Iran. Average daily rice consumption of the citizens and most widely used rice brands in the market of Iranshahr were determined using a questionnaire. Besides, the concentration of heavy metals in the gathered rice samples was measured by inductively coupled plasma mass spectrometry (ICP-MS). Monte Carlo uncertainty simulation was utilized in conducting exposure assessment and investigating the non-carcinogenic effects of the studied elements as well as the carcinogenic effect of As. Concentrations of As, Cd, Pb, Cu, Al, and Mo were 0.369 ± 0.094, 0.0337 ± 0.039, 0.123 ± 0.14, 3.095 ± 439.42, 39.6 ± 14.73, and 1.106 ± 0.133 mg kg�1, respectively. Al (0.18 ± 0.15 mg kg�1 d�1) and Cd (0.00015 ± 0.00034 mg kg�1 d�1) were the highest and lowest estimated daily intake, respectively. Except As (5.23 ± 4.01), the calculated hazard quotient for investigated elements showed no non-carcinogenic health risk. Besides, the simulation of the carcinogenic risk effect for As (2.37E-3) revealed that the ingestion of the studied rice brands would cause cancer risk due to lifetime consumption. Results show that consumption of rice in the Iranshahr city is a potential source of exposure to the studied elements. © 2018 Elsevier Lt

Degradation of furfural in aqueous solution using activated persulfate and peroxymonosulfate by ultrasound irradiation

Furfural is a toxic compound that can cause many problems for human health and the environment. In this study, we addressed the degradation of furfural in aqueous solution using the activated persulfate (SPS) and peroxymonosulfate (PMS) through the ultrasonic (US) wave. Besides, the effect of various parameters (pH, oxidizing dose, initial furfural concentration, US frequency, Inorganic anions concentration, and scavenger) on SPS + US (SPS/US) and PMS + US (PMS/US) processes were examined. The results showed, in order to furfural removal, the US had excellent efficiency in activating SPS and PMS, as in SPS/US and PMS/US processes, 95.3 and 58.4 of furfural (at 25 mg/L concentration) was decomposed in 90 min, respectively. The furfural degradation rate increased with increasing oxidizing dose and US frequency in both SPS/US and PMS/US processes. Considering the synergistic effect, the best removal rate has occurred in the SPS/US process. In the SPS/US and PMS/US processes, furfural removal increased at natural pH (pH 7), and the presence of inorganic anions such as NO3 � and Cl� had negative effects on furfural removal efficiency. Also CO3 2� and HCO3 � acted as a radical scavenger in the SPS/US process but these anions in the PMS/US process produced more SO4 �° radicals, and subsequently, they increased the furfural degradation rate. The results also showed that the predominant radical in the oxidation reactions is the sulfate radical. This study showed that the SPS/US and PMS/US processes are promising methods for degrading organic pollutants in the environment. © 2020 Elsevier Lt

Evaluation of Noise Pollution in Small Workshops in Qom, Iran; and Its Situation Compared to National Noise Standards

Background & Aims of the Study: Noise is one of the most important environmental pollutants. It is a global health problem, especially among industrial workers. Since there was little information about noise levels in small workshops in Qom city, this study aimed to evaluate noise in small workshops and compare it with national standards. Materials and Methods: This was a cross-sectional study. Initially jobs and workshops that were causing noise pollution were identified. Then, noise was measured with a calibrated sound dosimeter, model CASELLA CEL-320, in A-network, in 108 working places. The results were compared with national noise standards. Results: The total number of workers in the workshops were 317 people, and inside the workshops 76.3% of the workers and 66.7% of the workshops were exposed to noise over the standard threshold. Outside the workshops, in 89% noise pollution was higher than the standard city values. Only 11% of noise pollution in the city workshops, had a 1 or less than 1 dB difference with the standard noise threshold. Conclusion: Small workshops cause a significant amount of noise pollution in Qom city. This can affect the workers’ and the public’s health. Noise control procedures such as controlling the source, and direction of noise distribution, as well as setting up workshops in the right location, and far from residential areas is necessary