The Space Debris Sensor Experiment

The Space Debris Sensor (SDS) is a NASA Class 1E technology demonstration external payload aboard the International Space Station (ISS). With approximately one square meter of detection area, the SDS is attached to the European Space Agency Columbus module facing the ISS velocity vector with minimal obstruction from ISS hardware. The SDS is the first flight demonstration of the Debris Resistive/Acoustic Grid Orbital NASA-Navy Sensor (DRAGONS) technology developed and matured over 10 years by the NASA Orbital Debris Program Office (ODPO), in concert with the DRAGONS consortium, to provide information on the sub-millimeter scale orbital debris environment. The SDS demonstrated the capacity to read 4 resistive grids at 1 Hz, 40 acoustic sensors at 500 kHz, and record and downlink impact data to the ground. Observable and derived data from the SDS could provide information to models that are critical to understanding risks the small debris environment poses to spacecraft in low Earth orbit. The technology demonstrated by the SDS is a major step forward in monitoring and characterizing the space debris environment. This paper will address the technical performance of the SDS during its operational lifetime and its realization of technical and scientific goals. The SDS was intended to operate for 3 years; however, the payload incurred multiple anomalies during its operational life. Subsequently termed Anomaly #1, the first was the symptomatic loss of low data rate 1553 channel command and telemetry. The second, Anomaly #2, was loss of all low- and medium-data rate (Ethernet) telemetry. Anomaly #2 proved to be unrecoverable, leading to loss of the payload after approximately 26 days on-board the ISS. Therefore, this paper also addresses the anomalies that occurred during operation of the SDS, their attribution, and their resolution. Lessons learned are described when relevant to anomaly identification, attribution, and resolution

Thermodynamics of molecular recognitions between antineoplastic drug taxol and phosphatidylcholine

The aim of this study was to study the basic features of Taxol recognition with phospholipids by applying the thermodynamic and spectroscopic measurements. The obtained information could be used further for deductions on its precise cellular and pharmacological mechanisms of action, on improvements of its solubility properties by phospholipids, as well as for designing the novel lipidic carriers for drug delivery

Tween-Embedded Microemulsions—Physicochemical and Spectroscopic Analysis for Antitubercular Drugs

The microemulsion composed of oleic acid, phosphate buffer, ethanol, and Tween (20, 40, 60, and 80) has been investigated in the presence of antitubercular drugs of extremely different solubilities, viz. isoniazid (INH), pyrazinamide (PZA), and rifampicin (RIF). The phase behavior showing the realm of existence of microemulsion has been delineated at constant surfactant/co-surfactant ratio (Km = 0.55) with maximum isotropic region resulting in the case of Tween 80. The changes in the microstructure of Tween 80-based microemulsion in the presence of anti-TB drugs have been established using conductivty (σ) and viscosity (η) behavior. The optical microscopic images of the system help in understanding the effect of dilution and presence of drug on the structure of microemulsion. Partition coefficient, particle size analysis, and spectroscopic studies (UV–visible, Fourier transform infrared, and 1H NMR) have been performed to evaluate the location of a drug in the colloidal formulation. To compare the release of RIF, PZA, and INH from Tween 80 formulation, the dissolution studies have been carried out. It shows that the release of drugs follow the order INH>PZA>RIF. The kinetics of the release of drug has been analyzed using the Korsmeyer and Peppas equation. The results have given a fair success to predict that the release of PZA and INH from Tween 80 microemulsion is non-Fickian, whereas RIF is found to follow a Fickian mechanism