ロボット支援下胃切除の安全性評価と手術習熟過程の解析：多施設共同コホート研究

京都大学新制・課程博士博士(医学)甲第24480号医博第4922号新制||医||1063(附属図書館)京都大学大学院医学研究科医学専攻(主査)教授 波多野 悦朗, 教授 山本 洋介, 教授 小林 恭学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA

Strategy for treatment of stage IV human epidermal growth factor 2-positive gastric cancer: a case report

Abstract Background The prognosis of stage IV gastric cancer and human epidermal growth factor 2 (HER2)-positive gastric cancer is poor, although new drugs and regimens have been developed. We report a case of a patient with stage IV HER2-positive gastric cancer treated successfully by conversion therapy and trastuzumab. Case presentation The patient was a 73-year-old Japanese man diagnosed as L, type 3, circ, T4aNxCy1P1M1, stage IV (the Japanese classification of gastric carcinoma). The patient was treated with docetaxel, cisplatin, and TS-1 (DCS regimen). After two courses of the regimen, peritoneal dissemination disappeared, and peritoneal lavage cytology revealed no tumor cells in the abdominal cavity. Subsequently, he underwent laparoscopic distal gastrectomy with D1+. Pathological findings were ypT2(MP), ypN2(3/15), ypP0, ypCY0, M0, ypstage II. He received TS-1 as an adjuvant chemotherapy, but he had peritoneal recurrence. The original gastric cancer was HER2-positive. We therefore treated him with TS-1 with trastuzumab. This regimen was quite effective and achieved a complete response. After complete response, we switched the patient to trastuzumab monotherapy. He had no evidence of recurrence for 6 years, 3 months after surgery. Conclusion DCS regimen, R0 resection, and adjuvant chemotherapy with trastuzumab can be a powerful strategy for stage IV HER2-positive gastric cancer

Supplemental Material - Factors Associated With Postoperative Decisional Regret in Patients Undergoing Gastrointestinal Cancer Surgery: A Prospective Cohort Study

Supplemental Material for Factors Associated With Postoperative Decisional Regret in Patients Undergoing Gastrointestinal Cancer Surgery: A Prospective Cohort Study by Hiromitsu Kinoshita, Tatsuto Nishigori, Takayo Nakabe, Norihiro Shimoike, Keiko Sato, Yuichi Imanaka, Kazutaka Obama, and Yumi Matsumura in The American Surgeonâ„¢</p