Development of a rhythmic dance curriculum designed to stimulate "independent, interactive and deep learning"

In this study of a curriculum designed for rhythm-based dance, we consciously considered the stage of the participants’ development and the characteristics of rhythmic play, and practiced using "rhythm" and "expression" as keywords. As a result, the following points became clear. (1) The use of onomatopoeia, such as clapping and "don", which are frequently used on a daily basis, was effective in training the rhythmic feeling in lower grades. (2) Proceeding with the selection of songs, selecting songs with a BPM（Beat Per Minute） of about 100, is effective in training lower- and higher-grade children as it allows them to feel the rhythm of the music. (3) Junior high school students tend to have a higher interest in complex rhythms, and tend to learn the rhythms by imitating sample images from ICT equipment. (4) The “step acquisition” that triggers the movement and the activities that allow the children to express themselves and led to widespread improvisation among the younger children. (5) In higher-grade children, expressions of originality created new perspectives on concrete expressions of space, time, and power. (6) In junior high school students, improvised dance is performed through activities such as choreography, strength, strength, body angle, facial expression, and formation through activities that imitate sample images using ICT equipment. It is thought that it became possible

Long-term Measurements of Traffic Load Induced Settlement of Pavement Surface in Saga Airport Highway, Japan

. This study presents the long-term measurements of traffic load induced settlement of pavement surface in Saga airport highway, Japan. In addition, the subground characteristics of the deposit were discussed in associated with their typical properties such as; high sensitivity, high compressibility, and low bearing capacity. The basic features of deposit are characterized to be soft alluvial deposit with thickness 20 - 25 m with natural water contents are much higher than their corresponding liquid limits. Permeability of the salty clay layer is approximated 3 to 5 times of the Ariake clay permeability. The settlement profiles along the Saga airport highway visualized a non uniform differential settlement. Large differential settlement occurred in between the two box culverts supported by end bearing piles. A dynamic impact is considered as one factor affecting the large observed settlement in the central part of the road section between the two box culverts. The observed total settlement was around 0.5 m after 3 years open for traffic; it was mainly accumulated due to consolidation settlement of embankment highway. It can be justified that the settlement induced by traffic loading is approximately around 20% of the total settlement

Inhibition of NLRP3 inflammasome as a therapeutic intervention in crystal-induced nephropathy

Inflammasomes are important components of innate immunity system. Dysregulation of inflammasomes activation is central to the pathogenesis of inflammatory diseases. The measurement of inflammasomes activity especially in in vivo settings should give us important information to regulate inflammatory events. Ludwig-Portugall et al. clearly visualized the intrarenal activation of inflammasome in a murine model of crystal nephropathy using a proteolytic luciferase-based reporter, and showed that the blockade of NLRP3 inflammasome may prevent renal injuries. © 2016 International Society of NephrologyEmbargo Period 12 month

半月体形成性腎炎におけるp38 mitogen-activated protein kinaseの意義

取得学位：博士(医学), 学位授与番号：医博甲第1475号, 学位授与年月日：平成13年3月31日,学位授与年：200

慢性腎臓病(CKD)および腎心相関にはたすエピジェネティクスをかいした新規機序

金沢大学大学病院本年度は,慢性腎臓病の共通進展機序である腎間質線維化におけるエピジェネティクスの意義,ことにfibrocyteをかいしたエピジェネティクスの役割について取り組んだ.すなわち,確立された腎間質線維化モデルであるマウスー側尿管結紮(UUO)モデルを作成し,腎間質線維化におけるヒストンアセチル化,およびヒストンアセチル化阻害剤(curcumin)を用いて腎間質線維化に与える効果を検討した.さらに,ヒストンアセチル化が腎内ケモカイン発現にあたえる影響を検討し,fibrocyteの腎浸潤を評価した.また,培養fibrocyteのコラーゲン産生機序に対するヒストンアセチル化の関与を検討した.その結果,UUOモデルにおいて腎内HAT活性の亢進,尿細管上皮細胞ならびに間質浸潤細胞におけるアセチル化ヒストンの増加,腎内NF-κBのDNA結合能亢進,腎内MCP-1発現亢進およびfibrocyte腎浸潤を認め,腎間質線維化が進展した.一方HAT活性阻害剤であるcurcumin投与により,これらの変化が抑制されることを明らかにした.さらにヒトfibrocyteを用いた検討において,TGF-β_1刺激によりI型プロコラーゲンα1mRNA発現の亢進を認め,一方curucumin処置によりその発現が抑制されることを明らかにした.これは,UUOモデルにおいて腎内ヒストンアセチル化が(1)ケモカインシステムを介したfibrocyteの腎浸潤調節機序,および(2)浸潤fibrocyteのI型コラーゲン発現機序に寄与することを示唆するものである.このことから,ヒストンアセチル化は慢性腎臓病の共通進展機序である腎間質線維化の新規進展機序および治療標的分子として意義あるものである.研究課題/領域番号:21790802, 研究期間(年度):2009 – 2010出典：研究課題「慢性腎臓病(CKD)および腎心相関にはたすエピジェネティクスをかいした新規機序」課題番号21790802（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） （https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-21790802/）を加工して作

Involvement of bone-marrow-derived cells in kidney fibrosis

金沢大学医薬保健研究域医学系Cellular mechanisms have been proposed in the pathogenesis of fibrotic processes in the kidney. In this setting, cell sources underlying the generation of matrix-producing cells in diseased kidneys have been categorized as activated resident stromal cells (e.g., fibroblasts, pericytes), infiltrating bone-marrow-derived cells (e.g., fibrocytes, T cells, macrophages), and cells derived from epithelial-mesenchymal transition/endothelial-mesenchymal transition. Among these cell sources, accumulating evidence has shed light on the involvement of bone-marrow-derived cells, including monocytes/macrophages, and a circulating mesenchymal progenitor cell, fibrocyte, in the progression of fibrosis in kidney. Bone-marrow-derived cells positive for CD45 or CD34, and type 1 (pro)collagen dependent on the chemokine and renin-angiotensin systems migrate into diseased kidneys and enhance synthesis matrix protein, cytokines/chemokines, and profibrotic growth factors, which may promote and escalate chronic inflammatory processes and possible interaction with resident stromal cells, thereby perpetuating kidney fibrosis. © 2010 Japanese Society of Nephrology

Fibrocytes: A new insight into kidney fibrosis

金沢大学医学部附属病院血液浄化療法部Fibrocytes are supposed to be a circulating connective tissue cell progenitor, which consists of a novel population of peripheral blood cells. This distinct population of blood-borne cells shares markers of leukocytes as well as mesenchymal cells. Accumulating evidence indicates that fibrosis is characteristic of progressive chronic kidney diseases of any etiologies, resulting in kidney failure. We have uncovered that CCR7-positive fibrocytes migrate into the kidney in response to secondary lymphoid tissue chemokine (SLC/CCL21) and contribute to kidney fibrosis induced by unilateral ureteral obstruction in mice. In addition, the blockade of CCL21/CCR7 signaling by anti-CCL21 antibodies reduced kidney fibrosis, which was confirmed by a decrease in fibrosis in CCR7-null mice with concomitant reduction in macrophage recruitment along with reduced renal transcripts of monocyte chemoattractant protein-1 (MCP-1/CCL2). These findings suggest that fibrocytes dependent on CCL21/CCR7 signaling pathways contribute to the pathogenesis of kidney fibrosis, thereby providing that regulating fibrocytes may provide a novel therapeutic benefit for kidney fibrosis. © 2007 International Society of Nephrology

An Initial Case Report of a Laparoscopic Spleen-Preserving Distal Pancreatectomy for a Patent with a Pancreatic Metastasis of Malignant Melanoma

Article信州医学雑誌 63(1):19-24(2015)journal articl