40 research outputs found
Modeling the decoherence of spacetime
The question of whether unobserved short-wavelength modes of the
gravitational field can induce decoherence in the long-wavelength modes (``the
decoherence of spacetime'') is addressed using a simplified model of
perturbative general relativity, related to the Nordstrom-Einstein-Fokker
theory, where the metric is assumed to be conformally flat. For some
long-wavelength coarse grainings, the Feynman-Vernon influence phase is found
to be effective at suppressing the off-diagonal elements of the decoherence
functional. The requirement that the short-wavelength modes be in a
sufficiently high-temperature state places limits on the applicability of this
perturbative approach.Comment: 38 pages, REVTeX; 7 diagrams and 6 PostScript figures included via
epsfig. Final cosmetic changes made at publicatio
The role of binaries in the enrichment of the early Galactic halo. I. r-process-enhanced metal-poor stars
The detailed chemical composition of most metal-poor halo stars has been
found to be highly uniform, but a minority of stars exhibit dramatic
enhancements in their abundances of heavy neutron-capture elements and/or of
carbon. The key question for Galactic chemical evolution models is whether
these peculiarities reflect the composition of the natal clouds, or if they are
due to later mass transfer of processed material from a binary companion. If
the former case applies, the observed excess of certain elements was implanted
within selected clouds in the early ISM from a production site at interstellar
distances. Our aim is to determine the frequency and orbital properties of
binaries among these chemically peculiar stars. This information provides the
basis for deciding whether mass transfer from a binary companion is necessary
and sufficient to explain their unusual compositions. This paper discusses our
study of a sample of 17 moderately (r-I) and highly (r-II) r-process-element
enhanced VMP and EMP stars. High-resolution, low signal-to-noise spectra of the
stars were obtained at roughly monthly intervals over 8 years with the FIES
spectrograph at the Nordic Optical Telescope. From these spectra, radial
velocities with an accuracy of ~100 m/s were determined by cross-correlation
against an optimized template. 14 of the programme stars exhibit no significant
RV variation over this period, while 3 are binaries with orbits of typical
eccentricity for their periods, resulting in a normal binary frequency of
~18+-6% for the sample. Our results confirm our preliminary conclusion from
2011, based on partial data, that the chemical peculiarity of the r-I and r-II
stars is not caused by any putative binary companions. Instead, it was
imprinted on the natal molecular clouds of these stars by an external, distant
source. Models of the ISM in early galaxies should account for such mechanisms.Comment: 14 pages, 3 figures, accepted for publication in Astronomy and
Astrophysic
Evaluation of alternative solvents in common amide coupling reactions : replacement of dichloromethane and N,N-dimethylformamide
A range of alternative solvents have been evaluated within amidation reactions employing common coupling reagents with a view to identifying suitable replacements for dichloromethane and N,N-dimethylformamid
FRW Cosmology From Five Dimensional Vacuum Brans-Dicke Theory
We follow approach of induced matter theory for 5D vacuum BD, introduce
induced matter and potential in 4D hypersurfaces, and employ generalized FRW
type solution. We confine ourselves to scalar field and scale factors be
functions of the time. This makes the induced potential, by its definition,
vanishes. When the scale factor of fifth dimension and scalar field are not
constants, 5D eqs for any geometry admit a power law relation between scalar
field and scale factor of fifth dimension. Hence the procedure exhibits that 5D
vacuum FRW like eqs are equivalent, in general, to corresponding 4D vacuum ones
with the same spatial scale factor but new scalar field and coupling constant.
We show that 5D vacuum FRW like eqs or its equivalent 4D vacuum ones admit
accelerated solutions. For constant scalar field, eqs reduce to usual FRW eqs
with typical radiation dominated universe. For this situation we obtain
dynamics of scale factors for any geometry without any priori assumption. For
nonconstant scalar fields and spatially flat geometries, solutions are found to
be power law and exponential ones. We also employ weak energy condition for
induced matter, that allows negative/positive pressures. All types of solutions
fulfill WEC in different ranges. The power law solutions with negative/positive
pressures admit both decelerating and accelerating ones. Some solutions accept
shrinking extra dimension. By considering nonghost scalar fields and recent
observational measurements, solutions are more restricted. We illustrate that
accelerating power law solutions, which satisfy WEC and have nonghost fields,
are compatible with recent observations in ranges -4/3 < \omega </- -1.3151 and
1.5208 </- n < 1.9583 for dependence of fifth dimension scale factor with usual
scale factor. These ranges also fulfill condition nonghost fields in the
equivalent 4D vacuum BD eqs.Comment: 18 pages, 16 figures, 11 table
Protocol of a randomised, controlled trial comparing immediate curative therapy with conservative treatment in men aged âĽ75 years with non-metastatic high-risk prostate cancer (SPCG 19/GRand-P)
Background
Older men (aged âĽ75âyears) with high risk, non-metastatic prostate cancer (PCa) are increasingly treated with curative therapy (surgery or radiotherapy). However, it is unclear if curative therapy prolongs life and improves health-related quality of life (HRQoL) in this age group compared to conservative therapy, which has evolved considerably during the last decade.
Study Design
The Scandinavian Prostate Cancer Group (SPCG) 19/Norwegian Get-Randomized Research Group-Prostate (GRand-P) is a randomised, two-armed, controlled, multicentre, phase III trial carried out at study centres in Norway, Denmark, Finland, and Sweden.
Endpoints
The primary endpoints are overall survival and HRQoL (burden of disease scale, European Organisation for the Research and Treatment of Cancer [EORTC] Elderly Cancer patients). Secondary endpoints are PCa-specific survival, metastasis-free survival, role-functioning scale (EORTC quality of life questionnaire 30-item core), urinary irritative/obstructive scale (26-item Expanded Prostate Cancer Index Composite [EPIC-26]), bowel scale (EPIC-26), intervention-free survival, PCa morbidity, use of secondary and tertiary systemic therapies, mean quality-adjusted life-years (QALYs), and mean total healthcare costs.
Patients and Methods
A total of 980 men (aged âĽ75âyears) with non-metastatic, high-risk PCa will initially be screened with Geriatric 8 (G8) health status screening tool and Mini-COGŠ brief cognitive test. Participants identified by G8 as âfitâ or âfrailâ will be randomised (ratio 1:1) to either immediate curative therapy (radiotherapy or prostatectomy) or conservative therapy (endocrine therapy or observation). Participants who are unable or unwilling to participate in randomisation will be enrolled in a separate observation group. Randomised patients will be followed for 10âyears.
Trial Registration
Ethics approval has been granted in Norway (457593), Denmark (H-22051998), Finland (R23043) and Sweden (Dnr 2023-05296-01). The trial is registered on Clinicaltrials.org (NCT05448547)