Parallel Microflow Photochemistry: Process Optimization, Scale-up, and Library Synthesis

A novel, multimicrocapillary flow reactor (MμCFR) was constructed and applied to a series of sensitized photoadditions involving 2(5<i>H</i>)-furanones. The reactor allowed for rapid and energy-, time-, and space-efficient sensitizer screening, process optimization, validation, scale-up, and library synthesis

Photochemically Induced Intramolecular Radical Cyclization Reactions with Imines

The photochemically induced intramolecular hydrogen abstraction or hydrogen atom transfer in cyclic imines <b>8a</b>,<b>b</b> followed by a cyclization is investigated. Two types of products are observed, one resulting from the formation of a C–C bond, the other from the formation of a C–N bond. A computational study reveals that hydrogen is exclusively transferred to the imine nitrogen leading to a triplet diradical intermediate. After intersystem crossing, the resulting zwitterionic intermediate undergoes cyclization leading to the final product