Estrogen receptor-negative breast ductal carcinoma: clinicopathological features and MIB-1 (Ki-67) proliferative index association.

Breast cancer estrogen receptor (ER) status is one of the strong additional factors in predicting response of patients towards hormonal treatment. The main aim of this study was to assess the morphological characteristics and proliferative activity using MIB-1(Ki-67) of estrogen receptor negative invasive breast ductal carcinoma (NOS type) as well as to correlate these features with clinicopathological data. We also aim to study the expression of c-erbB2 in ER negative breast tumors. High proliferative rate (MIB-1 above 20%) was observed in 63 (63.6%) of 99 ER negative tumors and that these tumors were associated with high expression of c-erbB2 (57.6%). We observed that MIB-1 is a reliable independent prognostic indicator for ER negative infiltrating ductal carcinoma in this study

C-erbB2 overexpression shows strong positivity (3+) on the cell membrane by immunohistochemistry (×200 magnification).

<p>C-erbB2 overexpression shows strong positivity (3+) on the cell membrane by immunohistochemistry (×200 magnification).</p

Clinical outcome of ER-negative tumor cases (within 0 to 5 years follow up) in relation with morphological and clinicopathological data.

<p>Clinical outcome of ER-negative tumor cases (within 0 to 5 years follow up) in relation with morphological and clinicopathological data.</p

Correlation between tumor grade and menopausal status, tumor size, lymph node metastases in MIB-1 triple negative breast cancers.

<p>Correlation is significant at the 0.05 level (2-sided).</p

Significant correlation between tumor staging and tumor size, tumor grade, lymph node metastases in ER-negative tumor.

<p>Correlation is significant at the 0.05 level (2-sided).</p

Significant correlation between axillary lymph node metastases and tumor margin in ER-negative tumor.

<p>Correlation is significant at the 0.05 level (2-sided).</p

Immunohistochemical stain for ER in invasive breast carcinoma showing strong nuclear positivity (×200 magnification).

<p>Immunohistochemical stain for ER in invasive breast carcinoma showing strong nuclear positivity (×200 magnification).</p

Correlation between MIB-1 status with clinicopathological findings and morphologic features.

<p>Correlation is significant at the 0.05 level (2-sided).</p

Estrogen Receptor-Negative Breast Ductal Carcinoma: Clinicopathological Features and Mib-1 (Ki-67) Proliferative Index Association

Breast cancer estrogen receptor (ER) status is one of the strong additional factors in predicting response of patients towards hormonal treatment. The main aim of this study was to assess the morphological characteristics and proliferative activity using MIB-1(Ki-67) of estrogen receptor negative invasive breast ductal carcinoma (NOS type) as well as to correlate these features with clinicopathological data. We also aim to study the expression of c-erbB2 in ER negative breast tumors. High proliferative rate (MIB-1 above 20%) was observed in 63 (63.6%) of 99 ER negative tumors and that these tumors were associated with high expression of c-erbB2 (57.6%). We observed that MIB-1 is a reliable independent prognostic indicator for ER negative infiltrating ductal carcinoma in this study