A randomized controlled trial comparing Circle of Security Intervention and treatment as usual as interventions to increase attachment security in infants of mentally ill mothers: Study Protocol

Psychopathology in women after childbirth represents a significant risk factor for parenting and infant mental health. Regarding child development, these infants are at increased risk for developing unfavorable attachment strategies to their mothers and for subsequent behavioral, emotional and cognitive impairments throughout childhood. To date, the specific efficacy of an early attachment-based parenting group intervention under standard clinical outpatient conditions, and the moderators and mediators that promote attachment security in infants of mentally ill mothers, have been poorly evaluated

Sphalerons with CP-Violating Higgs Potentials

We investigate the effect on the sphaleron in the two Higgs doublet electroweak theory of including CP violation in the Higgs potential. To have better control over the relation between the sphaleron energy and the physical quantities in the theory, we show how to parametrize the Higgs potential in terms of physical masses and mixing angles, one of which causes CP violation. By altering this CP violating angle (and keeping the other physical quantities fixed) the sphaleron energy increases by up to 10%. We also calculate the static minimum energy path between adjacent vacua as a function of Chern-Simons number, using the method of gradient flow. The only effect CP violation has on the barrier is the change in height. As a by-product of our work on parametrization of the potential, we demonstrate that CP violation in the Higgs sector favours nearly degenerate light Higgs masses.Comment: 13pp LaTeX2e, 2 eps figs, uses graphicx, a

The Inflationary Brane-Antibrane Universe

We show how the motion through the extra dimensions of a gas of branes and antibranes can, under certain circumstances, produce an era of inflation as seen by observers trapped on a 3-brane, with the inflaton being the inter-brane separation. Although most of our discussion refers to arbitrary p-branes, when we need to be specific we assume that they are D-branes of Type II or Type I string theory. For realistic brane couplings, such as those arising in string theory, the inter-brane potentials are too steep to inflate the universe for acceptably long times. However, for special regions of the parameter space of brane-antibrane positions the brane motion is slow enough for there to be sufficient inflation. Inflation would be more generic in models where the inter-brane interactions are much weaker. The spectrum of primordial density fluctuations predicted has index n slightly less than 1, and an acceptable amplitude, provided that the extra dimensions have linear size 1/r ~ 10^{12} GeV. Reheating occurs as in hybrid inflation, with the tachyonic instability of the brane-antibrane system taking over for small separations. The tachyon field can induce a cascade mechanism within which higher-dimension branes annihilate into lower-dimension ones. We argue that such a cascade naturally stops with the production of 3-branes in 10-dimensional string theory.Comment: Final version published in JHE

Nondegenerate Fermions in the Background of the Sphaleron Barrier

We consider level crossing in the background of the sphaleron barrier for nondegenerate fermions. The mass splitting within the fermion doublets allows only for an axially symmetric ansatz for the fermion fields. In the background of the sphaleron we solve the partial differential equations for the fermion functions. We find little angular dependence for our choice of ansatz. We therefore propose a good approximate ansatz with radial functions only. We generalize this approximate ansatz with radial functions only to fermions in the background of the sphaleron barrier and argue, that it is a good approximation there, too.Comment: LATEX, 20 pages, 11 figure

Host adaptation to viruses relies on few genes with different cross-resistance properties

The deposited article is a post-print version and has peer review. This deposit is composed by the main article, and it hasn't any supplementary materials associated. The supplementary materials of the publication are only present in the editor's page of this article. This publication hasn't any creative commons license associated.Host adaptation to one parasite may affect its response to others. However, the genetics of these direct and correlated responses remains poorly studied. The overlap between these responses is instrumental for the understanding of host evolution in multiparasite environments. We determined the genetic and phenotypic changes underlying adaptation of Drosophila melanogaster to Drosophila C virus (DCV). Within 20 generations, flies selected with DCV showed increased survival after DCV infection, but also after cricket paralysis virus (CrPV) and flock house virus (FHV) infection. Whole-genome sequencing identified two regions of significant differentiation among treatments, from which candidate genes were functionally tested with RNAi. Three genes were validated--pastrel, a known DCV-response gene, and two other loci, Ubc-E2H and CG8492. Knockdown of Ubc-E2H and pastrel also led to increased sensitivity to CrPV, whereas knockdown of CG8492 increased susceptibility to FHV infection. Therefore, Drosophila adaptation to DCV relies on few major genes, each with different cross-resistance properties, conferring host resistance to several parasites.Fundação para a Ciência e a Tecnologia grants: (SFRH/BPD/62964/2009, SFRH/BD/82299/2011, PTDC/SAU-IMU/120673/2010); Austrian Science Fund grants: (P22725, P19467); European Research Council grant: (ArchAdapt); Instituto Gulbenkian de Ciência/Fundação Calouste Gulbenkian; Vetmeduni.info:eu-repo/semantics/publishedVersio

Fermion Production in the Background of Minkowski Space Classical Solutions in Spontaneously Broken Gauge Theory

We investigate fermion production in the background of Minkowski space solutions to the equations of motion of $SU(2)$ gauge theory spontaneously broken via the Higgs mechanism. First, we attempt to evaluate the topological charge $Q$ of the solutions. We find that for solutions $Q$ is not well-defined as an integral over all space-time. Solutions can profitably be characterized by the (integer-valued) change in Higgs winding number $\Delta N_H$. We show that solutions which dissipate at early and late times and which have nonzero $\Delta N_H$ must have at least the sphaleron energy. We show that if we couple a quantized massive chiral fermion to a classical background given by a solution, the number of fermions produced is $\Delta N_H$, and is not related to $Q$.Comment: Version to be published. Argument showing that the topological charge of solutions is undefined has been strengthened and clarified. Conclusions unchange

Projections of Atmospheric Nitrogen Deposition to the Chesapeake Bay Watershed

Atmospheric deposition is among the largest pathways of nitrogen loading to the Chesapeake Bay Watershed (CBW). The interplay between future climate and emission changes in and around the CBW will likely shift the future nutrient deposition abundance and chemical regime (e.g., oxidized vs. reduced nitrogen). In this work, a Representative Concentration Pathway from the Community Earth System Model is dynamically downscaled using a recently updated Weather Research and Forecasting model that subsequently drives the Community Multiscale Air Quality model coupled to the agroeconomic Environmental Policy Integrated Climate model. The relative impacts of emission and climate changes on atmospheric nutrient deposition are explored for a recent historical period and a period centered on 2050. The projected regional emissions in Community Multiscale Air Quality reflect current federal and state regulations, which use baseline and projected emission years 2011 and 2040, respectively. The historical simulations of 2-m temperature (T2) and precipitation (PRECIP) have cool and dry biases, and temperature and PRECIP are projected to both increase. Ammonium wet deposition agrees well with observations, but nitrate wet deposition is underpredicted. Climate and deposition changes increase simulated future ammonium fertilizer application. In the CBW by 2050, these changes (along with widespread decreases in anthropogenic nitrogen oxide and sulfur oxide emissions, and relatively constant ammonia emissions) decrease total nitrogen deposition by 21%, decrease annual average oxidized nitrogen deposition by 44%, and increase reduced nitrogen deposition by 10%. These results emphasize the importance of decreased anthropogenic emissions on the control of future nitrogen loading to the Chesapeake Bay in a changing climate

Oligodendrocytes in the mouse corpus callosum maintain axonal function by delivery of glucose

In the optic nerve, oligodendrocytes maintain axonal function by supplying lactate as an energy substrate. Here, we report that, in acute brain slices of the mouse corpus callosum, exogenous glucose deprivation (EGD) abolished compound action potentials (CAPs), which neither lactate nor pyruvate could prevent. Loading an oligodendrocyte with 20 mM glucose using a patch pipette prevented EGD-mediated CAP reduction in about 70% of experiments. Loading oligodendrocytes with lactate rescued CAPs less efficiently than glucose. In mice lacking connexin 47, oligodendrocyte filling with glucose did not prevent CAP loss, emphasizing the importance of glial networks for axonal energy supply. Compared with the optic nerve, the astrocyte network in the corpus callosum was less dense, and loading astrocytes with glucose did not prevent CAP loss during EGD. We suggest that callosal oligodendrocyte networks provide energy to sustain axonal function predominantly by glucose delivery, and mechanisms of metabolic support vary across different white matter regions

Design and implementation of deformation algorithms for computer assisted orthopedic surgery: application to virtual implant database and preliminary results

Fractures around the joints are more common cases in routine trauma surgery where the surgeons have to bend the osteosynthesis plates to fit geometrical boundaries of the specific patient. This is a complicated, time consuming, and technically demanding procedure. The average time for bending a single plate requires as long as twenty minutes. This paper presents the first trial to design and implement the deformation algorithms for computer assisted orthopedic surgery system to assist surgeons in this procedure. Our preliminary results are presented